Synthesis of an H 3 antagonist via sequential one-pot additions of a magnesium ate complex and an amine to a 1,4-ketoester followed by carbonyl-directed fluoride addition

Organic Process Research and Development

Volumn 16, Issue 8, 2012, Pages 1393-1403

  Hawkins, Joel M ^a   Dubé, Pascal ^a   Maloney, Mark T ^a   Wei, Lulin ^a   Ewing, Marcus ^a   Chesnut, Stephen M ^a   Denette, Joshua R ^a   Lillie, Brett M ^a   Vaidyanathan, Rajappa ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATE COMPLEX; CHEMOSELECTIVE; DIASTEREOSELECTIVE; FLOW REACTORS; FLUORIDE ADDITIONS; KETOESTER; LOWER REACTION TEMPERATURE; ONE POT; RAPID MIXING;

FLUORINE; ORGANIC COMPOUNDS; SYNTHESIS (CHEMICAL);

MAGNESIUM;

EID: 84865274693     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op300093j     Document Type: Article

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