Synthesis of a muscarinic receptor antagonist via a diastereoselective Michael reaction, selective deoxyfluorination and aromatic metal-halogen exchange reaction

Journal of Organic Chemistry

Volumn 66, Issue 20, 2001, Pages 6775-6786

  Mase, T ^a   Houpis, I N ^b   Akao, A ^a   Dorziotis, I ^b   Emerson, K ^b   Hoang, T ^b   Iida, T ^a   Itoh, T ^a   Kamei, K ^a   Kato, S ^a   Kato, Y ^a   Kawasaki, M ^a   Lang, F ^b   Lee, J ^b   Lynch, J ^b   Maligres, P ^b   Molina, A ^b   Nemoto, T ^a   Okada, S ^a   Reamer, R ^b   Song, J Z ^b   Tschaen, D ^b   Wada, T ^a   Zewge, D ^b   Volante, R P ^b   Reider, P J ^b   Tomimoto, K ^b   more..

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXCHANGE REACTION;

AMINATION; CATALYSIS; CHEMICAL BONDS; KETONES;

SYNTHESIS (CHEMICAL);

1,3 DIOXOLANE DERIVATIVE; KETONE DERIVATIVE; MUSCARINIC M3 RECEPTOR ANTAGONIST; ZINC CHLORIDE;

AMINATION; ARTICLE; CATALYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINATION; STEREOCHEMISTRY;

AMIDES; ANIMALS; HUMANS; HYDROCARBONS, FLUORINATED; MUSCARINIC ANTAGONISTS; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; STEREOISOMERISM;

EID: 0035812684     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0157425     Document Type: Article

References (118)