-
1
-
-
67449150231
-
Increasing burden of melanoma in the United States
-
Linos E, Swetter SM, Cockburn MG, Colditz GA, Clarke CA, ((2009)) Increasing burden of melanoma in the United States. J Invest Dermatol 129:: 1666--1674.
-
(2009)
J Invest Dermatol
, vol.129
, pp. 1666-1674
-
-
Linos, E.1
Swetter, S.M.2
Cockburn, M.G.3
Colditz, G.A.4
Clarke, C.A.5
-
2
-
-
77955635233
-
Cancer statistics, 2010
-
Jemal A, Siegel R, Xu J, Ward E, ((2010)) Cancer statistics, 2010. CA Cancer J Clin 60:: 277--300.
-
(2010)
CA Cancer J Clin
, vol.60
, pp. 277-300
-
-
Jemal, A.1
Siegel, R.2
Xu, J.3
Ward, E.4
-
3
-
-
0033837128
-
Malignant melanoma: prevention, early detection, and treatment in the 21st century
-
quiz 237-240
-
Rigel DS, Carucci JA (2000) Malignant melanoma: prevention, early detection, and treatment in the 21st century. CA Cancer J Clin 50: 215-236; quiz 237-240.
-
(2000)
CA Cancer J Clin
, vol.50
, pp. 215-236
-
-
Rigel, D.S.1
Carucci, J.A.2
-
4
-
-
0036896253
-
Mitogen-actived protein kinase activation is an early event in melanoma progression
-
Cohen C, Zavala-Pompa A, Sequeira JH, Shoji M, Sexton DG, et al. ((2002)) Mitogen-actived protein kinase activation is an early event in melanoma progression. Clin Cancer Res 8:: 3728--3733.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3728-3733
-
-
Cohen, C.1
Zavala-Pompa, A.2
Sequeira, J.H.3
Shoji, M.4
Sexton, D.G.5
-
5
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, et al. ((2002)) Mutations of the BRAF gene in human cancer. Nature 417:: 949--954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
-
6
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, et al. ((2010)) Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363:: 809--819.
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
Ribas, A.4
McArthur, G.A.5
-
7
-
-
78650303507
-
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian R, Shi H, Wang Q, Kong X, Koya RC, et al. ((2010)) Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468:: 973--977.
-
(2010)
Nature
, vol.468
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
Wang, Q.3
Kong, X.4
Koya, R.C.5
-
8
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, et al. ((2010)) COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468:: 968--972.
-
(2010)
Nature
, vol.468
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
Kim, S.Y.3
Thomas, S.R.4
Wardwell, L.5
-
9
-
-
0347444723
-
MicroRNAs: genomics, biogenesis, mechanism, and function
-
Bartel DP, ((2004)) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:: 281--297.
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
10
-
-
77953787211
-
MiR-33 contributes to the regulation of cholesterol homeostasis
-
Rayner KJ, Suarez Y, Davalos A, Parathath S, Fitzgerald ML, et al. ((2010)) MiR-33 contributes to the regulation of cholesterol homeostasis. Science 328:: 1570--1573.
-
(2010)
Science
, vol.328
, pp. 1570-1573
-
-
Rayner, K.J.1
Suarez, Y.2
Davalos, A.3
Parathath, S.4
Fitzgerald, M.L.5
-
11
-
-
79960963683
-
MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma
-
Ibrahim AF, Weirauch U, Thomas M, Grunweller A, Hartmann RK, et al. ((2011)) MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma. Cancer Res 71:: 5214--5224.
-
(2011)
Cancer Res
, vol.71
, pp. 5214-5224
-
-
Ibrahim, A.F.1
Weirauch, U.2
Thomas, M.3
Grunweller, A.4
Hartmann, R.K.5
-
12
-
-
51349141401
-
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
-
van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH, et al. ((2008)) Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A 105:: 13027--13032.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13027-13032
-
-
van Rooij, E.1
Sutherland, L.B.2
Thatcher, J.E.3
DiMaio, J.M.4
Naseem, R.H.5
-
13
-
-
79955629702
-
MicroRNA miR-125b induces senescence in human melanoma cells
-
Glud M, Manfe V, Biskup E, Holst L, Dirksen AM, et al. ((2011)) MicroRNA miR-125b induces senescence in human melanoma cells. Melanoma Res 21:: 253--256.
-
(2011)
Melanoma Res
, vol.21
, pp. 253-256
-
-
Glud, M.1
Manfe, V.2
Biskup, E.3
Holst, L.4
Dirksen, A.M.5
-
14
-
-
78649903941
-
Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma
-
Levy C, Khaled M, Iliopoulos D, Janas MM, Schubert S, et al. ((2010)) Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol Cell 40:: 841--849.
-
(2010)
Mol Cell
, vol.40
, pp. 841-849
-
-
Levy, C.1
Khaled, M.2
Iliopoulos, D.3
Janas, M.M.4
Schubert, S.5
-
15
-
-
79959769600
-
MicroRNA miR-196a controls melanoma-associated genes by regulating HOX-C8 expression
-
Mueller DW, Bosserhoff AK, ((2011)) MicroRNA miR-196a controls melanoma-associated genes by regulating HOX-C8 expression. Int J Cancer 129:: 1064--1074.
-
(2011)
Int J Cancer
, vol.129
, pp. 1064-1074
-
-
Mueller, D.W.1
Bosserhoff, A.K.2
-
16
-
-
60549112361
-
Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor
-
Segura MF, Hanniford D, Menendez S, Reavie L, Zou X, et al. ((2009)) Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc Natl Acad Sci U S A 106:: 1814--1819.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 1814-1819
-
-
Segura, M.F.1
Hanniford, D.2
Menendez, S.3
Reavie, L.4
Zou, X.5
-
17
-
-
80155208154
-
Functional microRNA screening using a comprehensive lentiviral human microRNA expression library
-
Poell JB, van Haastert RJ, Cerisoli F, Bolijn AS, Timmer LM, et al. ((2011)) Functional microRNA screening using a comprehensive lentiviral human microRNA expression library. BMC Genomics 12:: 546.
-
(2011)
BMC Genomics
, vol.12
, pp. 546
-
-
Poell, J.B.1
van Haastert, R.J.2
Cerisoli, F.3
Bolijn, A.S.4
Timmer, L.M.5
-
18
-
-
0025899234
-
Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture
-
Cory AH, Owen TC, Barltrop JA, Cory JG, ((1991)) Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun 3:: 207--212.
-
(1991)
Cancer Commun
, vol.3
, pp. 207-212
-
-
Cory, A.H.1
Owen, T.C.2
Barltrop, J.A.3
Cory, J.G.4
-
19
-
-
3242669872
-
Improved statistical methods for hit selection in high-throughput screening
-
Brideau C, Gunter B, Pikounis B, Liaw A, ((2003)) Improved statistical methods for hit selection in high-throughput screening. J Biomol Screen 8:: 634--647.
-
(2003)
J Biomol Screen
, vol.8
, pp. 634-647
-
-
Brideau, C.1
Gunter, B.2
Pikounis, B.3
Liaw, A.4
-
20
-
-
40749111551
-
A skin microRNA promotes differentiation by repressing 'stemness
-
Yi R, Poy MN, Stoffel M, Fuchs E, ((2008)) A skin microRNA promotes differentiation by repressing 'stemness'. Nature 452:: 225--229.
-
(2008)
Nature
, vol.452
, pp. 225-229
-
-
Yi, R.1
Poy, M.N.2
Stoffel, M.3
Fuchs, E.4
-
21
-
-
47249097988
-
BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells
-
Sala E, Mologni L, Truffa S, Gaetano C, Bollag GE, et al. ((2008)) BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells. Mol Cancer Res 6:: 751--759.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 751-759
-
-
Sala, E.1
Mologni, L.2
Truffa, S.3
Gaetano, C.4
Bollag, G.E.5
-
22
-
-
33748030422
-
Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases
-
Sharma A, Tran MA, Liang S, Sharma AK, Amin S, et al. ((2006)) Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases. Cancer Res 66:: 8200--8209.
-
(2006)
Cancer Res
, vol.66
, pp. 8200-8209
-
-
Sharma, A.1
Tran, M.A.2
Liang, S.3
Sharma, A.K.4
Amin, S.5
-
23
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, et al. ((1994)) Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:: 527--532.
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
Vanhaesebroeck, B.4
Gout, I.5
-
24
-
-
13944282215
-
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
-
Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, et al. ((2005)) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433:: 769--773.
-
(2005)
Nature
, vol.433
, pp. 769-773
-
-
Lim, L.P.1
Lau, N.C.2
Garrett-Engele, P.3
Grimson, A.4
Schelter, J.M.5
-
25
-
-
84856905433
-
Role of the apoptotic and mitotic regulator survivin in melanoma
-
McKenzie JA, Grossman D, ((2012)) Role of the apoptotic and mitotic regulator survivin in melanoma. Anticancer Res 32:: 397--404.
-
(2012)
Anticancer Res
, vol.32
, pp. 397-404
-
-
McKenzie, J.A.1
Grossman, D.2
-
26
-
-
84859492189
-
Anti-oncogenic MicroRNA-203 Induces Senescence by Targeting E2F3 Protein in Human Melanoma Cells
-
Noguchi S, Mori T, Otsuka Y, Yamada N, Yasui Y, et al. ((2012)) Anti-oncogenic MicroRNA-203 Induces Senescence by Targeting E2F3 Protein in Human Melanoma Cells. J Biol Chem 287:: 11769--11777.
-
(2012)
J Biol Chem
, vol.287
, pp. 11769-11777
-
-
Noguchi, S.1
Mori, T.2
Otsuka, Y.3
Yamada, N.4
Yasui, Y.5
-
27
-
-
34548329963
-
MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster
-
Xu S, Witmer PD, Lumayag S, Kovacs B, Valle D, ((2007)) MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. J Biol Chem 282:: 25053--25066.
-
(2007)
J Biol Chem
, vol.282
, pp. 25053-25066
-
-
Xu, S.1
Witmer, P.D.2
Lumayag, S.3
Kovacs, B.4
Valle, D.5
-
28
-
-
21844478747
-
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
-
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, et al. ((2005)) Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436:: 117--122.
-
(2005)
Nature
, vol.436
, pp. 117-122
-
-
Garraway, L.A.1
Widlund, H.R.2
Rubin, M.A.3
Getz, G.4
Berger, A.J.5
-
29
-
-
25844508786
-
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation
-
Gupta PB, Kuperwasser C, Brunet JP, Ramaswamy S, Kuo WL, et al. ((2005)) The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet 37:: 1047--1054.
-
(2005)
Nat Genet
, vol.37
, pp. 1047-1054
-
-
Gupta, P.B.1
Kuperwasser, C.2
Brunet, J.P.3
Ramaswamy, S.4
Kuo, W.L.5
-
30
-
-
79953055600
-
Efficient in vivo microRNA targeting of liver metastasis
-
Huynh C, Segura MF, Gaziel-Sovran A, Menendez S, Darvishian F, et al. ((2011)) Efficient in vivo microRNA targeting of liver metastasis. Oncogene 30:: 1481--1488.
-
(2011)
Oncogene
, vol.30
, pp. 1481-1488
-
-
Huynh, C.1
Segura, M.F.2
Gaziel-Sovran, A.3
Menendez, S.4
Darvishian, F.5
-
31
-
-
79956131573
-
Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny
-
Cheli Y, Giuliano S, Botton T, Rocchi S, Hofman V, et al. ((2011)) Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny. Oncogene 30:: 2307--2318.
-
(2011)
Oncogene
, vol.30
, pp. 2307-2318
-
-
Cheli, Y.1
Giuliano, S.2
Botton, T.3
Rocchi, S.4
Hofman, V.5
-
32
-
-
33847220364
-
Melanoma biology and new targeted therapy
-
Gray-Schopfer V, Wellbrock C, Marais R, ((2007)) Melanoma biology and new targeted therapy. Nature 445:: 851--857.
-
(2007)
Nature
, vol.445
, pp. 851-857
-
-
Gray-Schopfer, V.1
Wellbrock, C.2
Marais, R.3
-
33
-
-
38849203228
-
In vivo switching of human melanoma cells between proliferative and invasive states
-
Hoek KS, Eichhoff OM, Schlegel NC, Dobbeling U, Kobert N, et al. ((2008)) In vivo switching of human melanoma cells between proliferative and invasive states. Cancer Res 68:: 650--656.
-
(2008)
Cancer Res
, vol.68
, pp. 650-656
-
-
Hoek, K.S.1
Eichhoff, O.M.2
Schlegel, N.C.3
Dobbeling, U.4
Kobert, N.5
-
34
-
-
77952502408
-
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
-
Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, et al. ((2010)) A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 141:: 583--594.
-
(2010)
Cell
, vol.141
, pp. 583-594
-
-
Roesch, A.1
Fukunaga-Kalabis, M.2
Schmidt, E.C.3
Zabierowski, S.E.4
Brafford, P.A.5
-
35
-
-
74249084440
-
miR-15a and miR-16-1 in cancer: discovery, function and future perspectives
-
Aqeilan RI, Calin GA, Croce CM, ((2010)) miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ 17:: 215--220.
-
(2010)
Cell Death Differ
, vol.17
, pp. 215-220
-
-
Aqeilan, R.I.1
Calin, G.A.2
Croce, C.M.3
-
36
-
-
18744396337
-
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
-
Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, et al. ((2002)) Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 99:: 15524--15529.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 15524-15529
-
-
Calin, G.A.1
Dumitru, C.D.2
Shimizu, M.3
Bichi, R.4
Zupo, S.5
-
37
-
-
52649088391
-
miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes
-
Liu Q, Fu H, Sun F, Zhang H, Tie Y, et al. ((2008)) miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res 36:: 5391--5404.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 5391-5404
-
-
Liu, Q.1
Fu, H.2
Sun, F.3
Zhang, H.4
Tie, Y.5
-
38
-
-
67650422613
-
miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer
-
Bandi N, Zbinden S, Gugger M, Arnold M, Kocher V, et al. ((2009)) miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer Res 69:: 5553--5559.
-
(2009)
Cancer Res
, vol.69
, pp. 5553-5559
-
-
Bandi, N.1
Zbinden, S.2
Gugger, M.3
Arnold, M.4
Kocher, V.5
-
39
-
-
25444520537
-
miR-15 and miR-16 induce apoptosis by targeting BCL2
-
Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, et al. ((2005)) miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 102:: 13944--13949.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 13944-13949
-
-
Cimmino, A.1
Calin, G.A.2
Fabbri, M.3
Iorio, M.V.4
Ferracin, M.5
-
40
-
-
18444418797
-
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
-
McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, et al. ((2002)) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109:: 707--718.
-
(2002)
Cell
, vol.109
, pp. 707-718
-
-
McGill, G.G.1
Horstmann, M.2
Widlund, H.R.3
Du, J.4
Motyckova, G.5
-
41
-
-
4944249733
-
Deregulated Akt3 activity promotes development of malignant melanoma
-
Stahl JM, Sharma A, Cheung M, Zimmerman M, Cheng JQ, et al. ((2004)) Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res 64:: 7002--7010.
-
(2004)
Cancer Res
, vol.64
, pp. 7002-7010
-
-
Stahl, J.M.1
Sharma, A.2
Cheung, M.3
Zimmerman, M.4
Cheng, J.Q.5
-
42
-
-
79953325104
-
PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
-
Paraiso KH, Xiang Y, Rebecca VW, Abel EV, Chen YA, et al. ((2011)) PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res 71:: 2750--2760.
-
(2011)
Cancer Res
, vol.71
, pp. 2750-2760
-
-
Paraiso, K.H.1
Xiang, Y.2
Rebecca, V.W.3
Abel, E.V.4
Chen, Y.A.5
-
44
-
-
49949117302
-
Widespread changes in protein synthesis induced by microRNAs
-
Selbach M, Schwanhausser B, Thierfelder N, Fang Z, Khanin R, et al. ((2008)) Widespread changes in protein synthesis induced by microRNAs. Nature 455:: 58--63.
-
(2008)
Nature
, vol.455
, pp. 58-63
-
-
Selbach, M.1
Schwanhausser, B.2
Thierfelder, N.3
Fang, Z.4
Khanin, R.5
-
45
-
-
29144470346
-
Real-time quantification of microRNAs by stem-loop RT-PCR
-
Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, et al. ((2005)) Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33:: e179.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Chen, C.1
Ridzon, D.A.2
Broomer, A.J.3
Zhou, Z.4
Lee, D.H.5
-
46
-
-
80555154056
-
Sample preparation for small RNA massive parallel sequencing
-
Gommans WM, Berezikov E, ((2012)) Sample preparation for small RNA massive parallel sequencing. Methods Mol Biol 786:: 167--178.
-
(2012)
Methods Mol Biol
, vol.786
, pp. 167-178
-
-
Gommans, W.M.1
Berezikov, E.2
-
47
-
-
33751548288
-
Diversity of microRNAs in human and chimpanzee brain
-
Berezikov E, Thuemmler F, van Laake LW, Kondova I, Bontrop R, et al. ((2006)) Diversity of microRNAs in human and chimpanzee brain. Nat Genet 38:: 1375--1377.
-
(2006)
Nat Genet
, vol.38
, pp. 1375-1377
-
-
Berezikov, E.1
Thuemmler, F.2
van Laake, L.W.3
Kondova, I.4
Bontrop, R.5
|