Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4)

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 34, 2012, Pages

  Palmisano, Ilaria ^a   Della Chiara, Giulia ^a   D'Ambrosio, Rosa Lucia ^a   Huichalaf, Claudia ^a   Brambilla, Paola ^a   Corbetta, Silvia ^a   Riba, Michela ^a   Piccirillo, Rosanna ^b   Valente, Sergio ^c   Casari, Giorgio ^a,d   Mai, Antonello ^c   Boneschi, Filippo Martinelli ^a   Gabellini, Davide ^a   Poli, Guido ^a,d   Schiaffino, Maria Vittoria ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

GPR143; HIV 1 latency; Ocular albinism type 1; TNF alpha; Tyrosine

Indexed keywords

ANTIRETROVIRUS AGENT; CYSTEINE; ESSENTIAL AMINO ACID; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE INHIBITOR; METHIONINE; TRANSCRIPTOME;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; EPIGENETICS; GENE EXPRESSION; GENE REPLACEMENT THERAPY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MONOCYTE MACROPHAGE PRECURSOR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MALNUTRITION; PROVIRUS; RETROVIRUS; REVERSE TRANSCRIPTION; T LYMPHOCYTE; TRANSCRIPTION INITIATION; TRANSGENE; UPREGULATION; VIRUS LATENCY; VIRUS TRANSCRIPTION;

ALBINISM, OCULAR; DNA METHYLATION; DOWN-REGULATION; EYE PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, VIRAL; GENE SILENCING; HELA CELLS; HISTONE DEACETYLASES; HIV-1; HUMANS; MEMBRANE GLYCOPROTEINS; PROMOTER REGIONS, GENETIC; PROVIRUSES; REPRESSOR PROTEINS; TRANSCRIPTIONAL ACTIVATION; TRANSGENES; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

EID: 84865194183     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1202174109     Document Type: Article

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