Ndrg2 regulates vertebral specification in differentiating somites

Developmental Biology

Volumn 369, Issue 2, 2012, Pages 308-318

  Zhu, Huang ^a   Zhao, Jianzhi ^a   Zhou, Wenrong ^a   Li, Hanjun ^a   Zhou, Rujiang ^a   Zhang, Lingling ^a   Zhao, Haixia ^a   Cao, Jingjing ^a   Zhu, Xuming ^a   Hu, Hongliang ^c   Ma, Gang ^a   He, Lin ^a   Yao, Zhengju ^a   Yao, Libo ^b   Guo, Xizhi ^a,d  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d NONE   (China)

Author keywords

Bmp Smad signaling; Differentiating somites; Homeotic transformation; Hox genes; Ndrg2; Vertebral patterning

Indexed keywords

BONE MORPHOGENETIC PROTEIN; SMAD PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CONTROLLED STUDY; DEVELOPMENTAL STAGE; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENE EXPRESSION; GENE INACTIVATION; GENE LOSS; GENE OVEREXPRESSION; GENETIC SCREENING; GENETIC TRANSCRIPTION; GROWTH REGULATION; HOXC8 11 GENE; LUMBAR VERTEBRA; LUMBOSACRAL SPINE; MALE; MESODERM; MOLECULAR DYNAMICS; MOUSE; NDRG2 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PENETRANCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOMITE; SPINE DISEASE; THORACIC SPINE; TUMOR SUPPRESSOR GENE; VERTEBRA; VERTEBRATE;

MUS;

EID: 84865193697     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2012.07.001     Document Type: Article

References (66)

1. Alexander T., et al. Hox genes and segmentation of the hindbrain and axial skeleton. Annu. Rev. Cell Dev. Biol. 2009, 25:431-456.
2. Aulehla A., et al. Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev. Cell 2003, 4:395-406.
3. Burke A.C., et al. Hox genes and the evolution of vertebrate axial morphology. Development 1995, 121:333-346.
4. Cambray N., Wilson V. Two distinct sources for a population of maturing axial progenitors. Development 2007, 134:2829-2840.
5. Carapuco M., et al. Hox genes specify vertebral types in the presomitic mesoderm. Genes Dev. 2005, 19:2116-2121.
6. Dequeant M.L., Pourquie O. Segmental patterning of the vertebrate embryonic axis. Nat. Rev. Genet. 2008, 9:370-382.
7. Dubrulle J., Pourquie O. Coupling segmentation to axis formation. Development 2004, 131:5783-5793.
8. Dubrulle J., et al. FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation. Cell 2001, 106:219-232.
9. Dupays L., et al. Tbx2 misexpression impairs deployment of second heart field derived progenitor cells to the arterial pole of the embryonic heart. Dev Biol. 2009, 333:121-131.
10. Foletta V.C., et al. NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors. J. Physiol. 2009, 587:1619-1634.
11. Forlani S., et al. Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo. Development 2003, 130:3807-3819.
12. Green E.L. Genetic and non-genetic factors which influence the type of the skeleton in an inbred strain of mice. Genetics 1941, 26:192-222.
13. Guo X., et al. Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev. 2004, 18:2404-2417.
14. Hirsinger E., et al. Somite formation and patterning. Int. Rev. Cytol. 2000, 198:1-65.
15. Hostikka S.L., et al. Axial and appendicular skeletal transformations, ligament alterations, and motor neuron loss in Hoxc10 mutants. Int. J. Biol. Sci. 2009, 5:397-410.
16. Hu X.L., et al. Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues. Cell Tissue Res. 2006, 325:67-76.
17. Hwang J., et al. Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. J. Biol. Chem. 2011, 286:12450-12460.
18. Iimura T., Pourquie O. Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression. Nature 2006, 442:568-571.
19. Iimura T., Pourquie O. Hox genes in time and space during vertebrate body formation. Dev. Growth Differ. 2007, 49:265-275.
20. Iimura T., et al. Establishment of Hox vertebral identities in the embryonic spine precursors. Curr. Top Dev. Biol. 2009, 88:201-234.
21. Ikeya M., Takada S. Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression. Mech. Dev. 2001, 103:27-33.
22. Ikeya M., et al. Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development 2006, 133:4463-4473.
23. Juan A.H., Ruddle F.H. Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer. Development 2003, 130:4823-4834.
24. Katagiri T., et al. Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. Dev. Genet. 1998, 22:340-348.
25. Kessel M., Gruss P. Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 1991, 67:89-104.
26. Kieny M., et al. Early regionalization of somitic mesoderm as studied by the development of axial skeleton of the chick embryo. Dev. Biol. 1972, 28:142-161.
27. Kmita M., Duboule D. Organizing axes in time and space; 25 years of colinear tinkering. Science 2003, 301:331-333.
28. Krumlauf R. Hox genes in vertebrate development. Cell 1994, 78:191-201.
29. Le Mouellic H., et al. Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene. Cell 1992, 69:251-264.
30. Lee Y.J., et al. Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development. Dev. Biol. 2010, 347:195-203.
31. Li Y., et al. N-myc downstream-regulated gene 2, a novel estrogen-targeted gene, is involved in the regulation of Na+/K+-ATPase. J. Biol. Chem. 2011, 286:32289-32299.
32. Liu F., et al. Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues. Int. J. Dev. Biol. 2004, 48:645-653.
33. Liu W., et al. N-myc downstream regulated gene 1 modulates Wnt-beta-catenin signalling and pleiotropically suppresses metastasis. EMBO Mol. Med. 2012, 4:93-108.
34. Maconochie M., et al. Paralogous Hox genes: function and regulation. Annu. Rev. Genet. 1996, 30:529-556.
35. Mallo M., et al. Hox genes and regional patterning of the vertebrate body plan. Dev. Biol. 2010, 344:7-15.
36. McIntyre D.C., et al. Hox patterning of the vertebrate rib cage. Development 2007, 134:2981-2989.
37. McMahon J.A., et al. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 1998, 12:1438-1452.
38. McPherron A.C., et al. Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11. Nat. Genet. 1999, 22:260-264.
39. Miura S., et al. BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development 2006, 133:3767-3775.
40. Nowicki J.L., Burke A.C. Hox genes and morphological identity: axial versus lateral patterning in the vertebrate mesoderm. Development 2000, 127:4265-4275.
41. O'Higgins P., Johnson D.R. The inheritance of vertebral shape in the mouse. II. A study using Fourier analysis to examine the inheritance of patterns of vertebral variation in the cervical and upper thoracic vertebral column. J. Anat. 1993, 182(Pt 1):65-73.
42. Oh S.P., Li E. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 1997, 11:1812-1826.
43. Oh S.P., et al. Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning. Genes Dev. 2002, 16:2749-2754.
44. Okuda T., Kondoh H. Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem. Biophys. Res. Commun. 1999, 266:208-215.
45. Okuda T., et al. Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol. Cell Biol. 2004, 24:3949-3956.
46. Ovchinnikov D.A., et al. Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice. Genesis 2000, 26:145-146.
47. Partanen J., et al. Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev. 1998, 12:2332-2344.
48. Pizette S., et al. BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb. Development 2001, 128:4463-4474.
49. Pollock R.A., et al. Altering the boundaries of Hox3.1 expression: evidence for antipodal gene regulation. Cell 1992, 71:911-923.
50. Pourquie O. Vertebrate segmentation: from cyclic gene networks to scoliosis. Cell 2011, 145:650-663.
51. Reshef R., et al. Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression. Genes Dev. 1998, 12:290-303.
52. Suemori H., et al. Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs. Mech. Dev. 1995, 51:265-273.
53. Takahashi K., et al. Ndrg2 promotes neurite outgrowth of NGF-differentiated PC12 cells. Neurosci. Lett. 2005, 388:157-162.
54. Taketomi Y., et al. Impaired mast cell maturation and degranulation and attenuated allergic responses in Ndrg1-deficient mice. J. Immunol. 2007, 178:7042-7053.
55. Tschopp P., Duboule D. A genetic approach to the transcriptional regulation of Hox gene clusters. Annu. Rev. Genet. 2011, 45:145-166.
56. van den Akker E., et al. Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes. Development 2001, 128:1911-1921.
57. Wellik D.M. Hox patterning of the vertebrate axial skeleton. Dev. Dyn. 2007, 236:2454-2463.
58. Wellik D.M. Hox genes and vertebrate axial pattern. Curr. Top. Dev. Biol. 2009, 88:257-278.
59. Wellik D.M., Capecchi M.R. Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science 2003, 301:363-367.
60. Wurst W., et al. Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 1994, 120:2065-2075.
61. Yamamoto H., et al. NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia. J. Biol. Chem. 2011, 286:26158-26165.
62. Yang J., et al. NDRG2 in rat liver regeneration: role in proliferation and apoptosis. Wound Repair Regen. 2010, 18:524-531.
63. Yao L., et al. NDRG2: a Myc-repressed gene involved in cancer and cell stress. Acta Biochim. Biophys. Sin. (Shanghai) 2008, 40:625-635.
64. Young T., Deschamps J. Hox, Cdx, and anteroposterior patterning in the mouse embryo. Curr. Top. Dev. Biol. 2009, 88:235-255.
65. Zha L., et al. Collagen1alpha1 promoter drives the expression of Cre recombinase in osteoblasts of transgenic mice. J. Genet. Genomics 2008, 35:525-530.
66. Zhu X., et al. Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis. Dev. Biol. 2012.