Role of mature sphingolipids in yeast: New tools

Molecular Microbiology

Volumn 84, Issue 6, 2012, Pages 991-994

  Conzelmann, Andreas ^a  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AUREOBASIDIN A; CERAMIDE; CERAMIDE SYNTHASE; ERGOSTEROL; FAT DROPLET; GLYCOSYLPHOSPHATIDYLINOSITOL; INOSITOL PHOSPHORYLCERAMIDE SYNTHASE; LONG CHAIN FATTY ACID; PROTEIN AUR1P; PROTEIN KINASE; PROTEIN KINASE YPK1; SPHINGOLIPID; SYNTHETASE; THERMOZYMOCIDIN; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIFUNGAL RESISTANCE; BIOLOGICAL ACTIVITY; CELL FUNCTION; CELL SURVIVAL; CELL WALL; CELLULAR STRESS RESPONSE; CYTOKINESIS; ENDOCYTOSIS; ENZYME ACTIVITY; FUNGAL STRAIN; FUNGUS GROWTH; HEAT TOLERANCE; LIPID ANALYSIS; LIPID STORAGE; LIPOGENESIS; NONHUMAN; NOTE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; SACCHAROMYCES CEREVISIAE; YEAST; YEAST CELL;

CELL DIVISION; CERAMIDES; HEXOSYLTRANSFERASES; SACCHAROMYCES CEREVISIAE;

EID: 84865191719     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2012.08086.x     Document Type: Note

References (23)

1. Aguilar, P.S., Frohlich, F., Rehman, M., Shales, M., Ulitsky, I., Olivera-Couto, A., et al. (2010) A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nat Struct Mol Biol 17: 901-908.
2. Barz, W.P., and Walter, P. (1999) Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins. Mol Biol Cell 10: 1043-1059.
3. Beeler, T., Bacikova, D., Gable, K., Hopkins, L., Johnson, C., Slife, H., and Dunn, T. (1998) The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. J Biol Chem 273: 30688-30694.
4. Berchtold, D., Piccolis, M., Chiaruttini, N., Riezman, I., Riezman, H., Roux, A., et al. (2012) Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat Cell Biol 14: 542-547.
5. Bertin, A., McMurray, M.A., Thai, L., Garcia, G., Votin, V., Grob, P., et al. (2010) Phosphatidylinositol-4,5-bisphosphate promotes budding yeast septin filament assembly and organization. J Mol Biol 404: 711-731.
6. Cerantola, V., Vionnet, C., Aebischer, O.F., Jenny, T., Knudsen, J., and Conzelmann, A. (2007) Yeast sphingolipids do not need to contain very long chain fatty acids. Biochem J 401: 205-216.
7. Cerantola, V., Guillas, I., Roubaty, C., Vionnet, C., Uldry, D., Knudsen, J., and Conzelmann, A. (2009) Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. Mol Microbiol 71: 1523-1537.
8. Contreras, F.X., Ernst, A.M., Haberkant, P., Bjorkholm, P., Lindahl, E., Gonen, B., et al. (2012) Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature 481: 525-529.
9. Dickson, R.C. (2010) Roles for sphingolipids in Saccharomyces cerevisiae. Adv Exp Med Biol 688: 217-231.
10. Endo, M., Takesako, K., Kato, I., and Yamaguchi, H. (1997) Fungicidal action of aureobasidin A, a cyclic depsipeptide antifungal antibiotic, against Saccharomyces cerevisiae. Antimicrob Agents Chemother 41: 672-676.
11. Epstein, S., Castillon, G.A., Qin, Y., and Riezman, H. (2012) An essential function of sphingolipids in yeast cell division. Mol Microbiol 84: 1018-1032.
12. Fujita, M., Yoko-o, T., Okamoto, M., and Jigami, Y. (2004) GPI7 involved in glycosylphosphatidylinositol biosynthesis is essential for yeast cell separation. J Biol Chem 279: 51869-51879.
13. Kobayashi, T., Takematsu, H., Yamaji, T., Hiramoto, S., and Kozutsumi, Y. (2005) Disturbance of sphingolipid biosynthesis abrogates the signaling of Mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast. J Biol Chem 280: 18087-18094.
14. Levine, T.P., Wiggins, C.A., and Munro, S. (2000) Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae. Mol Biol Cell 11: 2267-2281.
15. Nagiec, M.M., Wells, G.B., Lester, R.L., and Dickson, R.C. (1993) A suppressor gene that enables Saccharomyces cerevisiae to grow without making sphingolipids encodes a protein that resembles an Escherichia coli fatty acyltransferase. J Biol Chem 268: 22156-22163.
16. Nagiec, M.M., Nagiec, E.E., Baltisberger, J.A., Wells, G.B., Lester, R.L., and Dickson, R.C. (1997) Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J Biol Chem 272: 9809-9817.
17. Roelants, F.M., Baltz, A.G., Trott, A.E., Fereres, S., and Thorner, J. (2010) A protein kinase network regulates the function of aminophospholipid flippases. Proc Natl Acad Sci USA 107: 34-39.
18. Roelants, F.M., Breslow, D.K., Muir, A., Weissman, J.S., and Thorner, J. (2011) Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 108: 19222-19227.
19. Saba, J.D., Nara, F., Bielawska, A., Garrett, S., and Hannun, Y.A. (1997) The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem 272: 26087-26090.
20. Schorling, S., Vallee, B., Barz,W.P., Riezman, H., and Oesterhelt, D. (2001) Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisiae. Mol Biol Cell 12: 3417-3427.
21. Tafesse, F.G., Huitema, K., Hermansson, M., van der Poel, S., van den Dikkenberg, J., Uphoff, A., et al. (2007) Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells. J Biol Chem 282: 17537-17547.
22. Tani, M., and Kuge, O. (2010) Defect of synthesis of very long-chain fatty acids confers resistance to growth inhibition by inositol phosphorylceramide synthase repression in yeast Saccharomyces cerevisiae. J Biochem 148: 565-571.
23. Vionnet, C., Roubaty, C., Ejsing, C.S., Knudsen, J., and Conzelmann, A. (2011) Yeast cells lacking all known ceramide synthases continue to make complex sphingolipids and to incorporate ceramides into glycosylphosphatidylinositol (GPI) anchors. J Biol Chem 286: 6769-6779.