Activation of AKT is associated with metastasis of nasopharyngeal carcinoma

Tumor Biology

Volumn 33, Issue 1, 2012, Pages 241-245

  Liu, Ying ^a   Chen, Long Hua ^a   Yuan, Ya Wei ^a   Li, Qi Sheng ^a   Sun, Ai Ming ^a   Guan, Jian ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

AKT; Cancer; Nasopharyngeal cancer; Radiation therapy

Indexed keywords

PROTEIN KINASE B;

ADULT; AGED; AKT1 GENE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER STAGING; CELL PROTECTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METASTASIS; MOLECULAR PATHOLOGY; NASOPHARYNX CARCINOMA; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; THERAPY EFFECT; TUMOR BIOPSY; UPREGULATION; WESTERN BLOTTING;

EID: 83655184636     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-011-0272-4     Document Type: Article

References (20)

1. KJ Marcus RB Tishler 2010 Head and neck carcinomas across the age spectrum: epidemiology, therapy, and late effects Semin Radiat Oncol 20 52 7 19959031 10.1016/j.semradonc.2009.09.004
2. M Agulnik JB Epstein 2008 Nasopharyngeal carcinoma: current management, future directions and dental implications Oral Oncol 44 617 27 18061518 10.1016/j.oraloncology.2007.08.003
3. F Sterzing E Stoiber S Nill H Bauer P Huber J Debus, et al. 2009 Intensity modulated radiotherapy (IMRT) in the treatment of children and adolescents-a single institution's experience and a review of the literature Radiat Oncol 4 37 19775449 10.1186/1748-717X-4-37
4. HH Loong BB Ma AT Chan 2008 Update on the management and therapeutic monitoring of advanced nasopharyngeal cancer Hematol Oncol Clin North Am 22 1267 78 19010273 10.1016/j.hoc.2008.08.012
5. HK Koon PS Chan RN-S Wong ZG Wu ML Lung CK Chang, et al. 2009 Targeted inhibition of the EGFR pathways enhances Zn-BC-AM PDT-induced apoptosis in well-differentiated nasopharyngeal carcinoma cells J Cell Biochem 108 1356 63 19816982 10.1002/jcb.22366 1:CAS:528:DC%2BD1MXhsV2gsr3J
6. C Freudlsperger JR Burnett JA Friedman VR Kannabiran Z Chen C Van Waes 2010 EGFRΓÇôPI3KΓÇôAKTΓÇ ômTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy Expert Opin Ther Targets 15 63 74 21110697 10.1517/14728222.2011.541440
7. M Ming YY He 2009 PTEN: new insights into its regulation and function in skin cancer J Invest Dermatol 129 2109 12 19340009 10.1038/jid.2009.79 1:CAS:528:DC%2BD1MXhtF2qsL3J
8. S Kfir-Erenfeld RV Sionov R Spokoini O Cohen E Yefenof 2010 Protein kinase networks regulating glucocorticoid-induced apoptosis of hematopoietic cancer cells: fundamental aspects and practical considerations Leuk Lymphoma 51 1968 2005 20849387 10.3109/10428194.2010.506570 1:CAS:528:DC%2BC3cXhsVektLrI
9. C Castaneda H Cortes-Funes H Gomez E Ciruelos 2010 The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer Cancer Meta Rev 29 751 9 10.1007/s10555-010-9261-0 1:CAS:528:DC%2BC3cXhtlant7zE
10. P Dent A Yacoub J Contessa R Caron G Amorino K Valerie, et al. 2003 Stress and radiation-induced activation of multiple intracellular signaling pathways1 Radiat Res 159 283 300 12600231 10.1667/0033-7587(2003)159[0283: SARIAO]2.0.CO;2 1:CAS:528:DC%2BD3sXitFyqsLg%3D (Pubitemid 36314943)
11. J Bussink AJ van der Kogel JH Kaanders 2008 Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer Lancet Oncol 9 288 96 18308254 10.1016/S1470-2045(08)70073-1 1:CAS:528:DC%2BD1cXivVaqtb0%3D (Pubitemid 351722948)
12. I Eke U Koch S Hehlgans V Sandfort F Stanchi D Zips, et al. 2010 PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1[alpha]. (Research article)(Report) J Clin Invest 120 2516 27 20530873 10.1172/JCI41078 1:CAS:528:DC%2BC3cXovFart70%3D
13. I Ayan E Kaytan N Ayan 2003 Childhood nasopharyngeal carcinoma: from biology to treatment Lancet Oncol 4 13 21 12517535 10.1016/S1470-2045(03)00956-2 1:CAS:528:DC%2BD3sXmsFyq (Pubitemid 36124186)
14. W Pao N Girard 2011 New driver mutations in non-small-cell lung cancer Lancet Oncol 12 175 80 21277552 10.1016/S1470-2045(10)70087-5 1:CAS:528:DC%2BC3MXht12ns74%3D
15. S Albert M Serova C Dreyer MP Sablin S Faivre E Raymond 2010 New inhibitors of the mammalian target of rapamycin signaling pathway for cancer Expert Opin Investig Drugs 19 919 30 20569080 10.1517/13543784.2010.499121 1:CAS:528:DC%2BC3cXovVCitL4%3D
16. N Jamil S Howie DM Salter 2010 Therapeutic molecular targets in human chondrosarcoma Int J Exp Pathol 91 387 93 21078112 10.1111/j.1365-2613.2010. 00749.x 1:CAS:528:DC%2BC3MXjslelsA%3D%3D
17. C Vens AC Begg 2010 Targeting base excision repair as a sensitization strategy in radiotherapy Semin Radiat Oncol 20 241 9 20832016 10.1016/j.semradonc.2010.05.005
18. VE Torres A Boletta A Chapman V Gattone Y Pei Q Qian, et al. 2010 Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases Clin J Am Societ Nephrol 5 1312 29 10.2215/CJN.01360210 1:CAS:528:DC%2BC3cXhtVehu7jP
19. I Vivanco CL Sawyers 2002 The phosphatidylinositol 3-kinase-AKT pathway in human cancer Nat Rev Cancer 2 489 501 12094235 10.1038/nrc839 1:CAS:528:DC%2BD38XkvFKltLs%3D (Pubitemid 37328931)
20. G Song G Ouyang S Bao 2005 The activation of Akt/PKB signaling pathway and cell survival J Cell Mol Med 9 59 71 15784165 10.1111/j.1582-4934.2005. tb00337.x 1:CAS:528:DC%2BD2MXlt1eqtLo%3D