Comparative evaluation of the biological properties of reducible and acid-sensitive folate prodrugs of a highly potent doxorubicin derivative

European Journal of Cancer

Volumn 48, Issue 13, 2012, Pages 2054-2065

  Abu Ajaj, Khalid ^a   El Abadla, Naser ^b   Welker, Pia ^c   Azab, Samar ^d   Zeisig, Reiner ^e   Fichtner, Iduna ^e   Kratz, Felix ^a  

^a TUMOR BIOLOGY CENTER   (Germany)

^b AL AQSA UNIVERSITY   (Palestine)

^c Mivenion GmbH   (Germany)

^d African Union Organization St Abbassia   (Egypt)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Acid sensitivity; Drug delivery; Drug targeting; Folate receptor targeting; Prodrug

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN DERIVATIVE; FOLATE RECEPTOR; KO 013; KO 019; N(5,5 DIACETOXYBUT 1 YL)DOXORUBICIN; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISULFIDE BOND; DRUG DESIGN; DRUG EFFICACY; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; DRUG UPTAKE; EVALUATION; FEMALE; FLUORESCENCE MICROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; INCUBATION TIME; MALE; MORTALITY; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; REDUCTION; TUMOR; TUMOR VOLUME; TUMOR XENOGRAFT; WEIGHT CHANGE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOXORUBICIN; DRUG EVALUATION, PRECLINICAL; FOLATE RECEPTORS, GPI-ANCHORED; FOLIC ACID; MICE; MICE, NUDE; PRODRUGS; PTERINS; VINCA ALKALOIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84865152010     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2011.08.003     Document Type: Article

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