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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 5, 2012, Pages 2020-2023

Hit to lead SAR study on benzoxazole derivatives for an NPY Y5 antagonist

(12) Omori, Naoki a Kouyama, Naoki a Yukimasa, Akira a Watanabe, Kana a Yokota, Yasunori a Tanioka, Hideki a Nambu, Hirohide a Yukioka, Hideo a Sato, Norihito a Tanaka, Yukari a Sekiguchi, Kazutaka a Okuno, Takayuki a

a SHIONOGI AND CO LTD (Japan)

Author keywords

Benzoxazole; GPCR; Hit to lead; NPY Y5 receptor antagonist; Obesity

Indexed keywords

BENZOXAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; FOOD INTAKE; IC 50; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; WEIGHT GAIN;

ANIMALS; ANTI-OBESITY AGENTS; BENZOXAZOLES; BODY WEIGHT; EATING; HUMANS; MICE; OBESITY; RATS; RECEPTORS, NEUROPEPTIDE Y; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863421507 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.01.027 Document Type: Article

Times cited : (17)

References (25)

1
- 84863402128
- http://www.cdc.gov/.

2
- 0029804743
- J.C. Erickson, G. Hollopeter, and R.D. Palmiter Science 274 1996 1704
- (1996) Science , vol.274 , pp. 1704
- Erickson, J.C.¹ Hollopeter, G.² Palmiter, R.D.³

3
- 4344622379
- M. Heilig Neuropeptides 38 2004 213 224
- (2004) Neuropeptides , vol.38 , pp. 213-224
- Heilig, M.¹

4
- 7444257413
- E. Obuchowicz, R. Krysiak, and Z.S. Herman Neurosci. Biobehav. Rev. 28 2004 595 610
- (2004) Neurosci. Biobehav. Rev. , vol.28 , pp. 595-610
- Obuchowicz, E.¹ Krysiak, R.² Herman, Z.S.³

5
- 0026711234
- H. Herzog, Y.J. Hort, H.J. Ball, G. Hayes, J. Shine, and L.A. Selbie Proc. Natl. Acad. Sci. U.S.A. 89 1992 5794
- (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 5794
- Herzog, H.¹ Hort, Y.J.² Ball, H.J.³ Hayes, G.⁴ Shine, J.⁵ Selbie, L.A.⁶

6
- 0030840674
- A.G. Blomqvist, and H. Herzog Trends Neurosci. 20 1997 294
- (1997) Trends Neurosci. , vol.20 , pp. 294
- Blomqvist, A.G.¹ Herzog, H.²

7
- 4344677881
- D.R. Gehlert Neuropeptides 38 2004 135
- (2004) Neuropeptides , vol.38 , pp. 135
- Gehlert, D.R.¹

8
- 0030709477
- A.O. Schaffhauser, A. Stricker-Krongrad, L. Brunner, F. Cumin, C. Gerald, S. Whitebread, L. Criscione, and K.G. Hofbauer Diabetes 46 1997 1792
- (1997) Diabetes , vol.46 , pp. 1792
- Schaffhauser, A.O.¹ Stricker-Krongrad, A.² Brunner, L.³ Cumin, F.⁴ Gerald, C.⁵ Whitebread, S.⁶ Criscione, L.⁷ Hofbauer, K.G.⁸

9
- 15844420659
- C. Gerald, M.W. Walker, L. Criscione, E.L. Gustafson, C. BatzlHartmann, K.E. Smith, P. Vaysse, M.M. Durkin, T.M. Laz, D.L. Linemeyer, A.O. Schaffhauser, S. Whitebread, K.G. Hofbauer, R.I. Taber, T.A. Branchek, and R.L. Weinshank Nature 382 1996 168
- (1996) Nature , vol.382 , pp. 168
- Gerald, C.¹ Walker, M.W.² Criscione, L.³ Gustafson, E.L.⁴ Batzlhartmann, C.⁵ Smith, K.E.⁶ Vaysse, P.⁷ Durkin, M.M.⁸ Laz, T.M.⁹ Linemeyer, D.L.¹⁰ Schaffhauser, A.O.¹¹ Whitebread, S.¹² Hofbauer, K.G.¹³ Taber, R.I.¹⁴ Branchek, T.A.¹⁵ Weinshank, R.L.¹⁶

10
- 84863416581
- A. Puopolo, S. Heshka, W. Karmally, R. Alvarado, S. Kakudo, T. Ochiai, W.T. Archambault, Y. Kobayashi, and B. Albata Obesity Soc. Ann. Sci. Meeting 2009 214-P
- (2009) Obesity Soc. Ann. Sci. Meeting
- Puopolo, A.¹ Heshka, S.² Karmally, W.³ Alvarado, R.⁴ Kakudo, S.⁵ Ochiai, T.⁶ Archambault, W.T.⁷ Kobayashi, Y.⁸ Albata, B.⁹

11
- 84863420551
- D. Smith, S. Heshka, W. Karmally, D. Doepner, Y. Narukawa, T. Ochiai, W.T. Archambault, Y. Kobayashi, and B. Albata Obesity Soc. Ann. Sci. Meeting 2009 221-P
- (2009) Obesity Soc. Ann. Sci. Meeting
- Smith, D.¹ Heshka, S.² Karmally, W.³ Doepner, D.⁴ Narukawa, Y.⁵ Ochiai, T.⁶ Archambault, W.T.⁷ Kobayashi, Y.⁸ Albata, B.⁹

12
- 78149282558
- D.A. Pizzi, C.P. Leslie, A. Mazzali, C. Seri, M. Biagetti, J. Bentley, T. Genski, R.D. Fabio, S. Contini, F.M. Sabbatini, L. Zonzini, and L. Caberlotto Bioorg. Med. Chem. Lett. 20 2010 7120
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 7120
- Pizzi, D.A.¹ Leslie, C.P.² Mazzali, A.³ Seri, C.⁴ Biagetti, M.⁵ Bentley, J.⁶ Genski, T.⁷ Fabio, R.D.⁸ Contini, S.⁹ Sabbatini, F.M.¹⁰ Zonzini, L.¹¹ Caberlotto, L.¹²

13
- 51349130429
- Y. Ogino, N. Ohtake, Y. Nagae, K. Matsuda, M. Ishikawa, M. Moriya, M. Kanesaka, Y. Mitobe, J. Ito, T. Kanno, A. Ishihara, H. Iwaasa, T. Ohe, A. Kanatani, and T. Fukami Bioorg. Med. Chem. Lett. 18 2008 4997
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 4997
- Ogino, Y.¹ Ohtake, N.² Nagae, Y.³ Matsuda, K.⁴ Ishikawa, M.⁵ Moriya, M.⁶ Kanesaka, M.⁷ Mitobe, Y.⁸ Ito, J.⁹ Kanno, T.¹⁰ Ishihara, A.¹¹ Iwaasa, H.¹² Ohe, T.¹³ Kanatani, A.¹⁴ Fukami, T.¹⁵

14
- 61449152798
- N. Sato, M. Jitsuoka, S. Ishikawa, K. Nagai, H. Tsuge, M. Ando, O. Okamoto, H. Iwaasa, A. Gomori, A. Ishihara, A. Kanatani, and T. Fukami Bioorg. Med. Chem. Lett. 19 2009 1670
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 1670
- Sato, N.¹ Jitsuoka, M.² Ishikawa, S.³ Nagai, K.⁴ Tsuge, H.⁵ Ando, M.⁶ Okamoto, O.⁷ Iwaasa, H.⁸ Gomori, A.⁹ Ishihara, A.¹⁰ Kanatani, A.¹¹ Fukami, T.¹²

15
- 38749139889
- G. Li, A.W. Stamford, Y. Huang, K.C. Cheng, J. Cook, C. Farley, J. Gao, L. Ghibaudi, W.J. Greenlee, M. Guzzi, M.V. Heek, J.J. Hwa, J. Kelly, D. Mullins, E.M. Parker, S. Wainhaus, and X. Zhang Bioorg. Med. Chem. Lett. 18 2008 1146
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 1146
- Li, G.¹ Stamford, A.W.² Huang, Y.³ Cheng, K.C.⁴ Cook, J.⁵ Farley, C.⁶ Gao, J.⁷ Ghibaudi, L.⁸ Greenlee, W.J.⁹ Guzzi, M.¹⁰ Heek, M.V.¹¹ Hwa, J.J.¹² Kelly, J.¹³ Mullins, D.¹⁴ Parker, E.M.¹⁵ Wainhaus, S.¹⁶ Zhang, X.¹⁷

16
- 77955422760
- M. Biagetti, C.P. Leslie, A. Mazzali, C. Seri, D.A. Pizzi, J. Bentley, T. Genski, R.D. Fabio, L. Zonzini, and L. Caberlotto Bioorg. Med. Chem. Lett. 20 2010 4741
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 4741
- Biagetti, M.¹ Leslie, C.P.² Mazzali, A.³ Seri, C.⁴ Pizzi, D.A.⁵ Bentley, J.⁶ Genski, T.⁷ Fabio, R.D.⁸ Zonzini, L.⁹ Caberlotto, L.¹⁰

17
- 49449105301
- N. Sato, M. Jitsuoka, T. Shibata, T. Hirohashi, K. Nonoshita, M. Moriya, Y. Haga, A. Sakuraba, M. Ando, T. Ohe, H. Iwaasa, A. Gomori, A. Ishihara, A. Kanatani, and T. Fukami J. Med. Chem. 51 2008 4765
- (2008) J. Med. Chem. , vol.51 , pp. 4765
- Sato, N.¹ Jitsuoka, M.² Shibata, T.³ Hirohashi, T.⁴ Nonoshita, K.⁵ Moriya, M.⁶ Haga, Y.⁷ Sakuraba, A.⁸ Ando, M.⁹ Ohe, T.¹⁰ Iwaasa, H.¹¹ Gomori, A.¹² Ishihara, A.¹³ Kanatani, A.¹⁴ Fukami, T.¹⁵

18
- 51349162920
- Y. Ogino, N. Ohtake, Y. Nagae, K. Matsuda, M. Moriya, T. Suga, M. Ishikawa, M. Kanesaka, Y. Mitobe, J. Ito, T. Kanno, A. Ishihara, H. Iwaasa, T. Ohe, A. Kanatani, and T. Fukami Bioorg. Med. Chem. Lett. 18 2008 5010
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 5010
- Ogino, Y.¹ Ohtake, N.² Nagae, Y.³ Matsuda, K.⁴ Moriya, M.⁵ Suga, T.⁶ Ishikawa, M.⁷ Kanesaka, M.⁸ Mitobe, Y.⁹ Ito, J.¹⁰ Kanno, T.¹¹ Ishihara, A.¹² Iwaasa, H.¹³ Ohe, T.¹⁴ Kanatani, A.¹⁵ Fukami, T.¹⁶

19
- 61349115065
- T. Sakamoto, M. Moriya, Y. Haga, T. Takahashi, T. Shibata, O. Okamoto, K. Nonoshita, H. Kitazawa, M. Hidaka, A. Gomori, H. Iwaasa, A. Ishihara, A. Kanatani, T. Fukami, Y.D. Gao, D.J. MacNeil, and L. Yang Bioorg. Med. Chem. Lett. 19 2009 1564
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 1564
- Sakamoto, T.¹ Moriya, M.² Haga, Y.³ Takahashi, T.⁴ Shibata, T.⁵ Okamoto, O.⁶ Nonoshita, K.⁷ Kitazawa, H.⁸ Hidaka, M.⁹ Gomori, A.¹⁰ Iwaasa, H.¹¹ Ishihara, A.¹² Kanatani, A.¹³ Fukami, T.¹⁴ Gao, Y.D.¹⁵ MacNeil, D.J.¹⁶ Yang, L.¹⁷

20
- 66249142634
- N. Sato, M. Ando, S. Ishikawa, M. Jitsuoka, K. Nagai, H. Takahashi, A. Sakuraba, H. Tsuge, H. Kitazawa, H. Iwaasa, S. Mashiko, A. Gomori, R. Moriya, N. Fujino, T. Ohe, A. Ishihara, A. Kanatani, and T. Fukami J. Med. Chem 52 2009 3385
- (2009) J. Med. Chem , vol.52 , pp. 3385
- Sato, N.¹ Ando, M.² Ishikawa, S.³ Jitsuoka, M.⁴ Nagai, K.⁵ Takahashi, H.⁶ Sakuraba, A.⁷ Tsuge, H.⁸ Kitazawa, H.⁹ Iwaasa, H.¹⁰ Mashiko, S.¹¹ Gomori, A.¹² Moriya, R.¹³ Fujino, N.¹⁴ Ohe, T.¹⁵ Ishihara, A.¹⁶ Kanatani, A.¹⁷ Fukami, T.¹⁸

21
- 84863402129
- Exploratory study from benzimidazole 2 will be reported in separate manuscript
- Exploratory study from benzimidazole 2 will be reported in separate manuscript.

22
- 0038248549
- R. Lok, R.E. Leone, and A.J. Williams J. Org. Chem. 61 1996 3289
- (1996) J. Org. Chem. , vol.61 , pp. 3289
- Lok, R.¹ Leone, R.E.² Williams, A.J.³

23
- 27644592070
- Z. Tian, D.J. Plata, S.J. Wittenberger, and A.V. Bhatia Tetrahedron Lett. 46 2005 8341
- (2005) Tetrahedron Lett. , vol.46 , pp. 8341
- Tian, Z.¹ Plata, D.J.² Wittenberger, S.J.³ Bhatia, A.V.⁴

24
- 79960006368
- J.P. Edwards, and C. Sturino Curr. Med. Chem. 18 2011 3116
- (2011) Curr. Med. Chem. , vol.18 , pp. 3116
- Edwards, J.P.¹ Sturino, C.²

25
- 80053004364
- A.F. Stepan, D.P. Walker, J. Bauman, D.A. Price, T.A. Baillie, A.S. Kalgutkar, and D.A. Michael Chem. Res. Toxicol 24 2011 1345
- (2011) Chem. Res. Toxicol , vol.24 , pp. 1345
- Stepan, A.F.¹ Walker, D.P.² Bauman, J.³ Price, D.A.⁴ Baillie, T.A.⁵ Kalgutkar, A.S.⁶ Michael, D.A.⁷

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