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Volumn 15, Issue 8, 2007, Pages 2027-2042

NPY5R antagonism does not augment the weight loss efficacy of orlistat or sibutramine

Author keywords

BMI; Neuropeptide Y; Obesity treatment; Overweight; Sibutramine

Indexed keywords


EID: 34548618969     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2007.242     Document Type: Article
Times cited : (30)

References (53)
  • 1
    • 0023544338 scopus 로고
    • Studies on the antiobesity activity of tetrahydrolipstatin, a potent and selective inhibitor of pancreatic lipase
    • Hogan S, FIeury A, Hadvary P, et al. Studies on the antiobesity activity of tetrahydrolipstatin, a potent and selective inhibitor of pancreatic lipase. Int J Obes. 1987;11(Suppl 3): 35-42.
    • (1987) Int J Obes , vol.11 , Issue.SUPPL. 3 , pp. 35-42
    • Hogan, S.1    FIeury, A.2    Hadvary, P.3
  • 2
    • 0034048643 scopus 로고    scopus 로고
    • Orlistat, a new lipase inhibitor for the management of obesity
    • Heck AM, Yanovski JA, Calis KA. Orlistat, a new lipase inhibitor for the management of obesity. Pharmacotherapy. 2000;20:270-9.
    • (2000) Pharmacotherapy , vol.20 , pp. 270-279
    • Heck, A.M.1    Yanovski, J.A.2    Calis, K.A.3
  • 3
    • 0025911832 scopus 로고
    • The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase
    • Hadvary P, Sidler W, Meister W, Vetter W, Wolfer H. The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase. J Biol Chem. 1991;266:2021-7.
    • (1991) J Biol Chem , vol.266 , pp. 2021-2027
    • Hadvary, P.1    Sidler, W.2    Meister, W.3    Vetter, W.4    Wolfer, H.5
  • 4
    • 0023791240 scopus 로고
    • Mode of action of tetrahydrolipstatin: A derivative of the naturally occurring lipase inhibitor lipstatin
    • Borgstrom B. Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin. Biochim Biophys Acta. 1988;962:308-16.
    • (1988) Biochim Biophys Acta , vol.962 , pp. 308-316
    • Borgstrom, B.1
  • 6
    • 15444368875 scopus 로고    scopus 로고
    • Serotonin (5-HT) drugs: Effects on appetite expression and use for the treatment of obesity
    • Halford JC, Harrold JA, Lawton CL, Blundell JE. Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr Drug Targets. 2005;6:201-13.
    • (2005) Curr Drug Targets , vol.6 , pp. 201-213
    • Halford, J.C.1    Harrold, J.A.2    Lawton, C.L.3    Blundell, J.E.4
  • 7
    • 2342453289 scopus 로고    scopus 로고
    • The efficacy and safety of sibutramine for weight loss: A systematic review
    • Arterburn DE, Crane PK, Veenstra DL. The efficacy and safety of sibutramine for weight loss: a systematic review. Arch Intern Med. 2004;164:994-1003.
    • (2004) Arch Intern Med , vol.164 , pp. 994-1003
    • Arterburn, D.E.1    Crane, P.K.2    Veenstra, D.L.3
  • 8
    • 0842312437 scopus 로고    scopus 로고
    • A systematic review of the clinical effectiveness of orlistat used for the management of obesity
    • O'Meara S, Riemsma R, Shirran L, Mather L, ter Riet G. A systematic review of the clinical effectiveness of orlistat used for the management of obesity. Obes Rev. 2004;5:51-68.
    • (2004) Obes Rev , vol.5 , pp. 51-68
    • O'Meara, S.1    Riemsma, R.2    Shirran, L.3    Mather, L.4    ter Riet, G.5
  • 9
    • 15944367788 scopus 로고    scopus 로고
    • Meta-analysis: Pharmacologic treatment of obesity
    • Li Z, Maglione M, Tu W, et al. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med. 2005;142:532-46.
    • (2005) Ann Intern Med , vol.142 , pp. 532-546
    • Li, Z.1    Maglione, M.2    Tu, W.3
  • 10
    • 4344696762 scopus 로고    scopus 로고
    • What interventions should we add to weight reducing diets in adults with obesity? A systematic review of randomized controlled trials of adding drug therapy, exercise, behaviour therapy or combinations of these interventions
    • Avenell A, Brown TJ, McGee MA, et al. What interventions should we add to weight reducing diets in adults with obesity? A systematic review of randomized controlled trials of adding drug therapy, exercise, behaviour therapy or combinations of these interventions. J Hum Nutr Diet. 2004;17:293-316.
    • (2004) J Hum Nutr Diet , vol.17 , pp. 293-316
    • Avenell, A.1    Brown, T.J.2    McGee, M.A.3
  • 11
    • 16544388896 scopus 로고    scopus 로고
    • Long-term pharmacotherapy for obesity and overweight
    • CD004094
    • Padwal R, Li SK, Lau DC. Long-term pharmacotherapy for obesity and overweight. Cochrane Database Syst Rev. 2004;3:CD004094.
    • (2004) Cochrane Database Syst Rev , pp. 3
    • Padwal, R.1    Li, S.K.2    Lau, D.C.3
  • 12
    • 0021248888 scopus 로고
    • Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats
    • Clark JT, Kalra PS, Crowley WR, Kalra SP. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology. 1984;115:427-9.
    • (1984) Endocrinology , vol.115 , pp. 427-429
    • Clark, J.T.1    Kalra, P.S.2    Crowley, W.R.3    Kalra, S.P.4
  • 13
    • 0033038418 scopus 로고    scopus 로고
    • Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
    • Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev. 1999;20:68-100.
    • (1999) Endocr Rev , vol.20 , pp. 68-100
    • Kalra, S.P.1    Dube, M.G.2    Pu, S.3    Xu, B.4    Horvath, T.L.5    Kalra, P.S.6
  • 15
    • 0032576608 scopus 로고    scopus 로고
    • Toward a new neurobiology of energy balance, appetite, and obesity: The anatomists weigh in
    • Sawchenko PE. Toward a new neurobiology of energy balance, appetite, and obesity: the anatomists weigh in. J Comp Neurol. 1998;402:435-41.
    • (1998) J Comp Neurol , vol.402 , pp. 435-441
    • Sawchenko, P.E.1
  • 16
    • 0033082380 scopus 로고    scopus 로고
    • From lesions to leptin: Hypothalamic control of food intake and body weight
    • Elmquist JK, Elias CF, Saper CB. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron. 1999;22:221-32.
    • (1999) Neuron , vol.22 , pp. 221-232
    • Elmquist, J.K.1    Elias, C.F.2    Saper, C.B.3
  • 17
    • 15844420659 scopus 로고    scopus 로고
    • A receptor subtype involved in neuropeptide-Y-induced food intake
    • Gerald C, Walker MW, Criscione L, et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 1996;382:168-71.
    • (1996) Nature , vol.382 , pp. 168-171
    • Gerald, C.1    Walker, M.W.2    Criscione, L.3
  • 18
    • 10244235259 scopus 로고    scopus 로고
    • Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior
    • Hu Y, Bloomquist BT, Cornfield LJ, et al. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J Biol Chem. 1996;271:26315-9.
    • (1996) J Biol Chem , vol.271 , pp. 26315-26319
    • Hu, Y.1    Bloomquist, B.T.2    Cornfield, L.J.3
  • 19
    • 0032535371 scopus 로고    scopus 로고
    • Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor
    • Criscione L, Rigollier P, Batzl-Hartmann C, et al. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J Clin Invest. 1998;102:2136-45.
    • (1998) J Clin Invest , vol.102 , pp. 2136-2145
    • Criscione, L.1    Rigollier, P.2    Batzl-Hartmann, C.3
  • 20
    • 0034680791 scopus 로고    scopus 로고
    • The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats
    • Cabrele C, Langer M, Bader R, et al. The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. J Biol Chem. 2000;275:36043-8.
    • (2000) J Biol Chem , vol.275 , pp. 36043-36048
    • Cabrele, C.1    Langer, M.2    Bader, R.3
  • 21
    • 0033625419 scopus 로고    scopus 로고
    • D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake
    • Parker EM, Balasubramaniam A, Guzzi M, et al. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake. Peptides. 2000;21:393-9.
    • (2000) Peptides , vol.21 , pp. 393-399
    • Parker, E.M.1    Balasubramaniam, A.2    Guzzi, M.3
  • 22
    • 0034858816 scopus 로고    scopus 로고
    • Identification of potent and selective neuropeptide Y Y(1) receptor agonists with orexigenic activity in vivo
    • Mullins D, Kirby D, Hwa J, Guzzi M, Rivier J, Parker E. Identification of potent and selective neuropeptide Y Y(1) receptor agonists with orexigenic activity in vivo. Mol Pharmacol. 2001;60:534-40.
    • (2001) Mol Pharmacol , vol.60 , pp. 534-540
    • Mullins, D.1    Kirby, D.2    Hwa, J.3    Guzzi, M.4    Rivier, J.5    Parker, E.6
  • 23
    • 0037096146 scopus 로고    scopus 로고
    • Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist
    • Daniels AJ, Grizzle MK, Wiard RP, Matthews JE, Heyer D. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul Pept. 2002;106:47-54.
    • (2002) Regul Pept , vol.106 , pp. 47-54
    • Daniels, A.J.1    Grizzle, M.K.2    Wiard, R.P.3    Matthews, J.E.4    Heyer, D.5
  • 24
    • 0038748202 scopus 로고    scopus 로고
    • Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: Chronic intracerebroventricular infusion of D-Trp(34)NPY
    • Mashiko S, Ishihara A, Iwaasa H, et al. Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp(34)NPY. Endocrinology. 2003;144:1793-801.
    • (2003) Endocrinology , vol.144 , pp. 1793-1801
    • Mashiko, S.1    Ishihara, A.2    Iwaasa, H.3
  • 25
    • 0037468535 scopus 로고    scopus 로고
    • Design and synthesis of the potent, orally available, brain-penetrable arylpyrazole class of neuropeptide Y5 receptor antagonists
    • Sato N, Takahashi T, Shibata T, et al. Design and synthesis of the potent, orally available, brain-penetrable arylpyrazole class of neuropeptide Y5 receptor antagonists. J Med Chem. 2003;46:666-9.
    • (2003) J Med Chem , vol.46 , pp. 666-669
    • Sato, N.1    Takahashi, T.2    Shibata, T.3
  • 26
    • 33646482230 scopus 로고    scopus 로고
    • A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice
    • Ishihara A, Kanatani A, Mashiko S, et al. A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice. Proc Natl Acad Sci USA. 2006;103:7154-8.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7154-7158
    • Ishihara, A.1    Kanatani, A.2    Mashiko, S.3
  • 27
    • 12144286708 scopus 로고    scopus 로고
    • Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: Comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice
    • Kanatani A, Mashiko S, Murai N, et al. Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. 2000;141:1011-6.
    • (2000) Endocrinology , vol.141 , pp. 1011-1016
    • Kanatani, A.1    Mashiko, S.2    Murai, N.3
  • 28
    • 0036320829 scopus 로고    scopus 로고
    • Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats
    • Turnbull AV, Ellershaw L, Masters DJ, et al. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. 2002;51:2441-9.
    • (2002) Diabetes , vol.51 , pp. 2441-2449
    • Turnbull, A.V.1    Ellershaw, L.2    Masters, D.J.3
  • 29
    • 0032417697 scopus 로고    scopus 로고
    • Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptordeficient mice
    • Kushi A, Sasai H, Koizumi H, et al. Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptordeficient mice. Proc Natl Acad Sci USA. 1998;95:15659-64.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15659-15664
    • Kushi, A.1    Sasai, H.2    Koizumi, H.3
  • 30
    • 0031779479 scopus 로고    scopus 로고
    • Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor
    • Pedrazzini T, Seydoux J, Kunstner P, et al. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nat Med. 1998;4:722-6.
    • (1998) Nat Med , vol.4 , pp. 722-726
    • Pedrazzini, T.1    Seydoux, J.2    Kunstner, P.3
  • 31
    • 0031779336 scopus 로고    scopus 로고
    • Role of the Y5 neuropeptide Y receptor in feeding and obesity
    • Marsh DJ, Hollopeter G, Kafer KE, Palmiter RD. Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat Med. 1998;4:718-21.
    • (1998) Nat Med , vol.4 , pp. 718-721
    • Marsh, D.J.1    Hollopeter, G.2    Kafer, K.E.3    Palmiter, R.D.4
  • 32
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    • Erickson JC, Clegg KE, Palmiter RD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 1996;381:415-21.
    • (1996) Nature , vol.381 , pp. 415-421
    • Erickson, J.C.1    Clegg, K.E.2    Palmiter, R.D.3
  • 33
    • 27344431720 scopus 로고    scopus 로고
    • NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    • Luquet S, Perez FA, Hnasko TS, Palmiter RD. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science. 2005;310:683-5.
    • (2005) Science , vol.310 , pp. 683-685
    • Luquet, S.1    Perez, F.A.2    Hnasko, T.S.3    Palmiter, R.D.4
  • 34
    • 33748920715 scopus 로고    scopus 로고
    • Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults
    • Erondu N, Gantz I, Musser B, et al. Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab. 2006;4:275-82.
    • (2006) Cell Metab , vol.4 , pp. 275-282
    • Erondu, N.1    Gantz, I.2    Musser, B.3
  • 35
    • 0030908378 scopus 로고    scopus 로고
    • James WP, Avenell A, Broom J. Whitehead J. A one-year trial to assess the value of orlistat in the management of obesity. Int J Obes Relat Metab Disord. 1997;21(Suppl 3): 24-30.
    • James WP, Avenell A, Broom J. Whitehead J. A one-year trial to assess the value of orlistat in the management of obesity. Int J Obes Relat Metab Disord. 1997;21(Suppl 3): 24-30.
  • 37
    • 0026877917 scopus 로고
    • The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection
    • Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. Med Care. 1992;30:473-83.
    • (1992) Med Care , vol.30 , pp. 473-483
    • Ware Jr, J.E.1    Sherbourne, C.D.2
  • 38
    • 0025688231 scopus 로고
    • c: A new facility for the measurement of health related quality of life
    • Euroqol Group
    • c: a new facility for the measurement of health related quality of life. Health Policy. 1990;16:199.
    • (1990) Health Policy , vol.16 , pp. 199
  • 39
    • 0043198343 scopus 로고    scopus 로고
    • Modern statistical methods for handling missing repeated measurements in obesity trial data: Beyond LOCF
    • Gadbury GL, Coffey CS, Allison DB. Modern statistical methods for handling missing repeated measurements in obesity trial data: beyond LOCF. Obes Rev. 2003;4:175-84.
    • (2003) Obes Rev , vol.4 , pp. 175-184
    • Gadbury, G.L.1    Coffey, C.S.2    Allison, D.B.3
  • 40
    • 34248342673 scopus 로고    scopus 로고
    • Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss
    • Erondu N, Wadden T, Gantz I, et al. Effect of NPY5R antagonist MK-0557 on weight regain after very-low-calorie diet-induced weight loss. Obesity. 2007;15:895-905.
    • (2007) Obesity , vol.15 , pp. 895-905
    • Erondu, N.1    Wadden, T.2    Gantz, I.3
  • 41
    • 0028847195 scopus 로고
    • The serotonin (5-HT) antagonist methysergide increases neuropeptide Y (NPY) synthesis and secretion in the hypothalamus of the rat
    • Dryden S, Wang Q, Frankish HM, Pickavance L, Williams G. The serotonin (5-HT) antagonist methysergide increases neuropeptide Y (NPY) synthesis and secretion in the hypothalamus of the rat. Brain Res. 1995;699:12-8.
    • (1995) Brain Res , vol.699 , pp. 12-18
    • Dryden, S.1    Wang, Q.2    Frankish, H.M.3    Pickavance, L.4    Williams, G.5
  • 42
    • 0029904648 scopus 로고    scopus 로고
    • Differential effects of the 5-HT 1B/2C receptor agonist mCPP and the 5-HT1A agonist flesinoxan on hypothalamic neuropeptide Y in the rat: Evidence that NPY may mediate serotonin's effects on food intake
    • Dryden S, Wang Q, Frankish HM, Williams G. Differential effects of the 5-HT 1B/2C receptor agonist mCPP and the 5-HT1A agonist flesinoxan on hypothalamic neuropeptide Y in the rat: evidence that NPY may mediate serotonin's effects on food intake. Peptides. 1996;:17:943-9.
    • (1996) Peptides , vol.17 , pp. 943-949
    • Dryden, S.1    Wang, Q.2    Frankish, H.M.3    Williams, G.4
  • 43
    • 0026013594 scopus 로고
    • Acute fenfluramine administration reduces neuropeptide Y concentrations in specific hypothalamic regions of the rat: Possible implications for the anorectic effect of fenfluramine
    • Rogers P, McKibbin PE, Williams G. Acute fenfluramine administration reduces neuropeptide Y concentrations in specific hypothalamic regions of the rat: possible implications for the anorectic effect of fenfluramine. Peptides. 1991;12:251-5.
    • (1991) Peptides , vol.12 , pp. 251-255
    • Rogers, P.1    McKibbin, P.E.2    Williams, G.3
  • 44
    • 0032793450 scopus 로고    scopus 로고
    • Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats
    • Grignaschi G, Fanelli E, Scagnol I, Samanin R. Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats. Br J Pharmacol. 1999;127:1190-4.
    • (1999) Br J Pharmacol , vol.127 , pp. 1190-1194
    • Grignaschi, G.1    Fanelli, E.2    Scagnol, I.3    Samanin, R.4
  • 45
    • 0346250180 scopus 로고    scopus 로고
    • Long-term pharmacotherapy for overweight and obesity: A systematic review and meta-analysis of randomized controlled trials
    • Padwal R, Li SK, Lau DC. Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Int J Obes Relat Metab Disord. 2003;27:1437-46.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 1437-1446
    • Padwal, R.1    Li, S.K.2    Lau, D.C.3
  • 46
    • 34548655203 scopus 로고    scopus 로고
    • Anti-obesity effects of a novel Y5 antagonist in diet-induced obese mice: Combination with food restriction or sibutramine
    • Submitted
    • Mashiko S, Ishihara A, Iwaasa H, et al. Anti-obesity effects of a novel Y5 antagonist in diet-induced obese mice: combination with food restriction or sibutramine. Submitted.
    • Mashiko, S.1    Ishihara, A.2    Iwaasa, H.3
  • 47
    • 13844321589 scopus 로고    scopus 로고
    • Efficacy of sibutramine, orlistat and combination therapy on short-term weight management in obese patients
    • Kaya A, Aydin N, Topsever P, et al. Efficacy of sibutramine, orlistat and combination therapy on short-term weight management in obese patients. Biomed Pharmacother. 2004;58:582-7.
    • (2004) Biomed Pharmacother , vol.58 , pp. 582-587
    • Kaya, A.1    Aydin, N.2    Topsever, P.3
  • 48
    • 12744260207 scopus 로고    scopus 로고
    • Efficacy and safety comparative evaluation of orlistat and sibutramine treatment in hypertensive obese patients
    • Derosa G, Cicero AF, Murdolo G, et al. Efficacy and safety comparative evaluation of orlistat and sibutramine treatment in hypertensive obese patients. Diabetes Obes Metab. 2005;7:47-55.
    • (2005) Diabetes Obes Metab , vol.7 , pp. 47-55
    • Derosa, G.1    Cicero, A.F.2    Murdolo, G.3
  • 49
    • 4544276140 scopus 로고    scopus 로고
    • Comparison of efficacy of sibutramine or orlistat versus their combination in obese women
    • Sari R, Balci MK, Cakir M, Altunbas H, Karayalcin U. Comparison of efficacy of sibutramine or orlistat versus their combination in obese women. Endocr Res. 2004;30:159-67.
    • (2004) Endocr Res , vol.30 , pp. 159-167
    • Sari, R.1    Balci, M.K.2    Cakir, M.3    Altunbas, H.4    Karayalcin, U.5
  • 50
    • 1842867123 scopus 로고    scopus 로고
    • Orlistat, sibutramine, or combination therapy: Which performs better on waist circumference in relation with body mass index in obese patients?
    • Aydin N, Topsever P, Kaya A, Karasakal M, Duman C, Dagar A. Orlistat, sibutramine, or combination therapy: which performs better on waist circumference in relation with body mass index in obese patients? Tohoku J Exp Med. 2004;202:173-80.
    • (2004) Tohoku J Exp Med , vol.202 , pp. 173-180
    • Aydin, N.1    Topsever, P.2    Kaya, A.3    Karasakal, M.4    Duman, C.5    Dagar, A.6
  • 51
    • 4544276140 scopus 로고    scopus 로고
    • Comparison of efficacy of sibutramine or orlistat versus their combination in obese women
    • Sari R, Balci MK, Cakir M, Altunbas H, Karayalcin U. Comparison of efficacy of sibutramine or orlistat versus their combination in obese women. Endocr Res. 2004;30:159-67.
    • (2004) Endocr Res , vol.30 , pp. 159-167
    • Sari, R.1    Balci, M.K.2    Cakir, M.3    Altunbas, H.4    Karayalcin, U.5
  • 52
    • 0036211099 scopus 로고    scopus 로고
    • Evaluation of the safety and efficacy of sibutramine, orlistat and metformin in the treatment of obesity
    • Gokcel A, Gumurdulu Y, Karakose H, et al. Evaluation of the safety and efficacy of sibutramine, orlistat and metformin in the treatment of obesity. Diabetes Obes Metab. 2002;4:49-55.
    • (2002) Diabetes Obes Metab , vol.4 , pp. 49-55
    • Gokcel, A.1    Gumurdulu, Y.2    Karakose, H.3
  • 53
    • 8644223451 scopus 로고    scopus 로고
    • Comparison of metabolic effects of orlistat and sibutramine treatment in Type 2 diabetic obese patients
    • Derosa G, Cicero AF, Murdolo G, Ciccarelli L, Fogari R. Comparison of metabolic effects of orlistat and sibutramine treatment in Type 2 diabetic obese patients. Diabetes Nutr Metab. 2004;17:222-9.
    • (2004) Diabetes Nutr Metab , vol.17 , pp. 222-229
    • Derosa, G.1    Cicero, A.F.2    Murdolo, G.3    Ciccarelli, L.4    Fogari, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.