Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5595-5599

  Cutshall, Neil S ^a   Onrust, Rene ^a   Rohde, Alex ^a   Gragerov, Sasha ^a   Hamilton, Lauren ^a   Harbol, Kevin ^a   Shen, Hui Rong ^a   McKee, Shawn ^a   Zuta, Charles ^a   Gragerova, Galina ^a   Florio, Vince ^a   Wheeler, Thomas N ^a   Gage, Jennifer L ^a  

^a OMEROS CORPORATION   (United States)

Author keywords

Cognitive; Enzyme inhibitor; Hydrazide; Hydrazone; PDE; PDE10; PDE10A; Phosphodiesterase; Schizophrenia

Indexed keywords

HYDRAZONE DERIVATIVE; OLANZAPINE; PHENCYCLIDINE; PHOSPHODIESTERASE 10A INHIBITOR; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; BINDING AFFINITY; CONTROLLED STUDY; DISEASE MODEL; DRUG ACTIVITY; HYPERACTIVITY; MOUSE; NONHUMAN; SCHIZOPHRENIA;

ANIMALS; ANTIPSYCHOTIC AGENTS; HYDRAZONES; MICE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; SCHIZOPHRENIA; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 84865133568     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.007     Document Type: Article

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