N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5485-5492

  Vallin, Karl S A ^a   Sterky, Karin J ^a   Nyman, Eva ^a   Bernström, Jenny ^a,b   From, Rebecka ^a   Linde, Christian ^a   Minidis, Alexander B E ^a   Nolting, Andreas ^a,b   Närhi, Katja ^a   Santangelo, Ellen M ^a   Sehgelmeble, Fernando W ^a   Sohn, Daniel ^a   Strindlund, Jennie ^a   Weigelt, Dirk ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Antagonist; Ion channel; TRPA1

Indexed keywords

CALCIUM ION; CARBAMIC ACID DERIVATIVE; ION TRANSPORT AFFECTING AGENT; KETONE; N 1 ALKYL 2 OXO 2 ARYL AMIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; COVALENT BOND; ELECTROPHILICITY; HIGH THROUGHPUT SCREENING; IN VIVO STUDY; ION CURRENT; PATCH CLAMP; STRUCTURE ACTIVITY RELATION; WHOLE CELL;

AMIDES; CALCIUM; CALCIUM CHANNELS; CARBAMATES; HUMANS; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSIENT RECEPTOR POTENTIAL CHANNELS; UREA;

EID: 84865121479     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.032     Document Type: Article

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