Signal mechanisms underlying low-dose endothelial monocyte-activating polypeptide-ii-induced opening of the blood-tumor barrier

Journal of Molecular Neuroscience

Volumn 48, Issue 1, 2012, Pages 291-301

  Li, Zhen ^a   Liu, Yun Hui ^a   Xue, Yi Xue ^a   Liu, Li Bo ^a   Wang, Ping ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Blood tumor barrier; Endothelial monocyte activating polypeptide II; Protein kinase C; Rho kinase; RhoA; Signaling pathway

Indexed keywords

COFILIN; ENDOTHELIAL MONOCYTE ACTIVATING POLYPEPTIDE II; MYOSIN LIGHT CHAIN; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C ZETA; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; BLOOD TUMOR BARRIER; CONCENTRATION RESPONSE; CYTOSOLIC FRACTION; ENZYME ACTIVITY; MICROVASCULAR ENDOTHELIAL CELL; NEWBORN; NONHUMAN; PERMEABILITY BARRIER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; CELL LINE, TUMOR; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLIOMA; GROWTH INHIBITORS; NEOPLASM PROTEINS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; RATS; RATS, WISTAR; RHOA GTP-BINDING PROTEIN; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION;

RATTUS;

EID: 84865120753     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9776-7     Document Type: Article

References (33)

1. Aras-López R, Xavier FE, Ferrer M et al (2009) Dexamethasone decreases neuronal nitric oxide release in mesenteric arteries from hypertensive rats through decreased protein kinase C activation. Clin Sci 117(8):305-312
2. Berger AC, Alexander HR, Tang G et al (2000) Endothelial monocyte activating polypeptide II induces endothelial cell apoptosis and may inhibit tumor angiogenesis. Microvasc Res 60(1):70-80 (Pubitemid 30456829)
3. Black KL, Ningaraj NS (2004) Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor. Cancer Control 11(3):165-173 (Pubitemid 38758221)
4. Brown RC, Davis TP (2005) Hypoxia/aglycemia alters expression of occludin and actin in brain endothelial cells. Biochem Biophys Res Commun 327(3):1114-1123 (Pubitemid 40142636)
5. Bucci M, RoviezZo F, Posadas I et al (2005) Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo. Proc Natl Acad Sci U S A 102(3):904-908 (Pubitemid 40282763)
6. Chen ML, Pothoulakis C, LaMont JT (2002) Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A. J Biol Chem 277(6):4247-4254 (Pubitemid 34968688)
7. Coghlan MP, Chou MM, Carpenter CL (2000) Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss. Mol Cell Biol 20(8):2880-2889 (Pubitemid 30183507)
8. Dodane V, Kachar B (1996) Identification of isoforms of G proteins and PKC that colocalize with tight junctions. J Membr Biol 149(3):199-209 (Pubitemid 26076105)
9. Fleegal MA, Hom S, Borg LK et al (2005) Activation of PKC modulates blood-brain barrier endothelial cell permeability changes induced by hypoxia and post-hypoxic reoxygenation. Am J Physiol Heart Circ Physiol 289(5):H2012-H2019 (Pubitemid 41507352)
10. Garcia JG, Davis HW, Patterson CE (1995) Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation. J Cell Physiol 163(3):510-522
11. Harhaj NS, Antonetti DA (2004) Regulation of tight junctions and loss of barrier function in pathophysiology. Int J Biochem Cell Bio 36(7):1206-1237 (Pubitemid 38519069)
12. Hatakeyama T, Pappas PJ, Hobson RW 2nd et al (2006) Endothelial nitric oxide synthase regulates microvascular hyperpermeability in vivo. J Physiol 574(1):275-281 (Pubitemid 43905811)
13. Ivanov AI, McCall IC, Parkos CA et al (2004) Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complex. Mol Biol Cell 15(6):2639-2651 (Pubitemid 38691854)
14. Li Z, Liu YH, Xue YX et al (2011) Mechanisms for endothelial monocyte-activating polypeptide-II-induced opening of the blood-tumor barrier. J Mol Neurosci. doi: 10.1007/s12031-011-9657-5
15. Liu LB, Xue YX, Liu YH et al (2008) Bradykinin increases blood-tumor barrier permeability by down-regulating the expression levels of ZO-1, occludin, and claudin-5 and rearranging actin cytoskeleton. J Neurosci Res 86(5):1153-1168 (Pubitemid 351441313)
16. Ma T, Xue YX (2010) RhoA-mediated potential regulation of blood-tumor barrier permeability by bradykinin. J Mol Neurosci 42(1):67-73
17. Madara JL (1998) Regulation of the movement of solutes across tight junctions. Annu Rev Physiol 60:143-159 (Pubitemid 28157868)
18. Mark KS, Burroughs AR, Brown RC et al (2004) Nitric oxide mediates hypoxia- induced changes in paracellular permeability of cerebral microvasculature. Am J Physiol Heart Circ Physiol 286(1):H174-H180 (Pubitemid 38049477)
19. Neri LM, Borgatti P, Capitani S et al (2002) Protein kinase C isoforms and lipid second messengers: a critical nuclear partnership? Histol Histopathol 17(4):1311-1316
20. Newton AC (1997) Regulation of protein kinase C. Curr Opin Cell Biol 9(2):161-167 (Pubitemid 27135982)
21. Nunbhakdi-Craig V, Machleidt T, Ogris E et al (2002) Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex. J Cell Biol 158(5):967-978 (Pubitemid 35001086)
22. Ron D, Kazanietz MG (1999) New insight into the regulation of protein kinase C and novel phorbol ester receptors. FASEB J 13(13):1658-1676 (Pubitemid 29473329)
23. Ross D, Joyner WL (1997) Resting distribution and stimulated translocation of protein kinase C isoforms alpha, epsilon and zeta in response to bradykinin and TNF in human endothelial cells. Endothelium 5(4):321-332 (Pubitemid 28177016)
24. Schmitz HP, Lorberg A, Heinisch JJ (2002) Regulation of yeast protein kinase C activity by interaction with the small GTPase Rho1p through its amino-terminal HR1 domain. Mol Microbiol 44(3):829-840 (Pubitemid 34526592)
25. Shalak V, Guigou L, Kaminska M et al (2007) Characterization of p43 (ARF), a derivative of the p43 component of multiaminoacyl-tRNA synthetase complex released during apoptosis. J Biol Chem 282(15):10935-10943 (Pubitemid 47100748)
26. Slater SJ, Seiz JL, Stagliano BA et al (2001) Interaction of protein kinase C isozymes with Rho GTPases. Biochemistry 40(14):4437-4445 (Pubitemid 32319589)
27. Steinberg SF (2008) Structural basis of protein kinase C isoform function. Physiol Rev 88(4):1341-1378
28. Tsai BM, Wang M, Clauss M et al (2004) Endothelial monocyte-activating polypeptide II causes NOS-dependent pulmonary artery vasodilation: a novel effect for a proinflammatory cytokine. Am J Physiol Regul Integr Comp Physiol 287(4):R767-R771 (Pubitemid 39280461)
29. Turner JR (2000) 'Putting the squeeze' on the tight junction: understanding cytoskeletal regulation. Semin Cell Dev Biol 11(4):301-308 (Pubitemid 32066137)
30. Wang L, Wu B, Sun Y et al (2010) Translocation of protein kinase C isoforms is involved in propofol-induced endothelial nitric oxide synthase activation. British J Anaesthesia 104(5):606-612
31. Xie H, Xue YX, Liu LB et al (2010) Endothelial-monocyte-activating polypeptide II increases blood-tumor barrier permeability by down-regulating the expression of tight junction associated proteins. Brain Res 1139:13-20
32. Xie H, Xue YX, Liu LB et al (2012) Role of RhoA/ROCK signaling in endothelial-monocyte-activating polypeptide II opening of the blood-tumor barrier. J Mol Neurosci 46(3):666-676
33. Yuan SY (2002) Protein kinase signaling in the modulation of microvascular permeability. Vascul Pharmacol 39(4-5):213-223 (Pubitemid 37490747)