Strong inhibition of UDP-glucuronosyltransferase (UGT) 1A1 by levothyroxine indicates the potential UGT-inhibition based adverse effect of levothyroxine

Latin American Journal of Pharmacy

Volumn 31, Issue 5, 2012, Pages 761-763

  Zhao, Hua Dong ^a   Bao, Guo Qiang ^a   He, Xian Li ^a   Wu, Tao ^a   Wang, Cheng Guo ^a   Wang, Sheng Zhi ^a   Zang, Li ^a   Lu, Jian Guo ^a   Du, Xi Lin ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Drug drug interaction; Levothyroxine; UDP glucuronosyltransferase (UGT) 1A1

Indexed keywords

GLUCURONOSYLTRANSFERASE 1A1; HYMECROMONE; LEVOTHYROXINE;

ARTICLE; CATALYSIS; DOSE RESPONSE; DRUG GLUCURONIDATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; IN VITRO STUDY; METABOLIC DISORDER;

EID: 84865088066     PISSN: 03262383     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. King, C.D., G.R. Rios, M.D. Green & T.R. Tephly. (2000) Curr. Drug Metab. 1: 143-61.
2. Mackenzie, P.I., I.S. Owens, B. Burchell, K.W. Bock, A. Belanger, S. Fournel-Giqleux et al. (1997) Pharmacogenetics 7: 255-69.
3. Mackenzie, P.I., K.W. Bock, B. Burchell, C. Guillemette, S. Ikushiro, T. Lyanaqi et al. (2005) Pharmacogenet. Genomics 15: 677-85.
4. Fisher, M.B., M.F. Paine, T.J. Strelevitz & S.A. Wrighton. (2001) Drug Metab. Rev. 33: 273-97.
5. Gil, J. & M.M. Sasiadek (2012) Biomarkers Med. 6: 223-30.
6. Di Paolo, A., G. Bocci, M. Polillo, M. Del Re, T. Di Desidero, M. Lastella et al. (2011) Curr. Drug Metab. 12: 932-43.
7. Visser, T.J. (1996) Acta. Med. Aust. 23: 10-6.
8. Dong, R.H., Z.Z. Fang, L.L. Zhu, S.C. Liang, G.B. Ge, L. Yang, et al. (2012) Phytother. Res. 26: 86-90.
9. Uchaipichat, V., P.I. Mackenzie, X.H. Guo, D. Gardner-Stephen, A. Galetin, J.B. Houston, et al. (2004) Drug Metab. Dispos. 32: 413-23.
10. Kato, Y., S. Ikushiro, Y. Emi, S. Tamaki, H. Suzuki, T. Sakaki et al. (2008) Drug Metab. Dispos. 36(1): 51-5.