Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in Atherosclerosis

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Magnusson, Lisa U ^a   Lundqvist, Annika ^a   Karlsson, Merja Nurkkala ^a   Skålén, Kristina ^a   Levin, Max ^a   Wiklund, Olov ^a   Borén, Jan ^a   Hultén, Lillemor Mattsson ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE TYPE B; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LENTIVIRUS VECTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ALOX15B GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BONE MARROW TRANSPLANTATION; CELL LEVEL; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; ENZYME ACTIVITY; FOAM CELL; GENE; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; LIPID STORAGE; LYMPHOCYTE COUNT; MACROPHAGE; MALE; MOUSE; NONHUMAN; T LYMPHOCYTE;

ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; ATHEROSCLEROSIS; CYTOKINES; FOAM CELLS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HUMANS; INFLAMMATION; MACROPHAGES; MICE; MICE, KNOCKOUT; RECEPTORS, LDL; RNA, SMALL INTERFERING;

EID: 84865076653     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043142     Document Type: Article

References (30)

1. Paoletti R, Gotto AM Jr, Hajjar DP, (2004) Inflammation in atherosclerosis and implications for therapy. Circulation 109: III20-26.
2. McLaren JE, Michael DR, Ashlin TG, Ramji DP, (2011) Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy. Prog Lipid Res 50: 331-347.
3. Libby P, Okamoto Y, Rocha VZ, Folco E, (2010) Inflammation in atherosclerosis: transition from theory to practice. Circ J 74: 213-220.
4. Kuhn H, O'Donnell VB, (2006) Inflammation and immune regulation by 12/15-lipoxygenases. Prog Lipid Res 45: 334-356.
5. Hedrick CC, Kim MD, Natarajan RD, Nadler JL, (1999) 12-Lipoxygenase products increase monocyte:endothelial interactions. Adv Exp Med Biol 469: 455-460.
6. Waddington E, Sienuarine K, Puddey I, Croft K, (2001) Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography. Anal Biochem 292: 234-244.
7. Ezaki M, Witztum JL, Steinberg D, (1995) Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase. J Lipid Res 36: 1996-2004.
8. Kuhn H, Belkner J, Suzuki H, Yamamoto S, (1994) Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities. J Lipid Res 35: 1749-1759.
9. Yla-Herttuala S, Luoma J, Viita H, Hiltunen T, Sisto T, et al. (1995) Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein. J Clin Invest 95: 2692-2698.
10. Funk CD, Cyrus T, (2001) 12/15-lipoxygenase, oxidative modification of LDL and atherogenesis. Trends Cardiovasc Med 11: 116-124.
11. Harats D, Shaish A, George J, Mulkins M, Kurihara H, et al. (2000) Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 20: 2100-2105.
12. Shen J, Herderick E, Cornhill JF, Zsigmond E, Kim HS, et al. (1996) Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development. J Clin Invest 98: 2201-2208.
13. Zhao L, Funk CD, (2004) Lipoxygenase pathways in atherogenesis. Trends Cardiovasc Med 14: 191-195.
14. Gertow K, Nobili E, Folkersen L, Newman JW, Pedersen TL, et al. (2011) 12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms. Atherosclerosis 215: 411-416.
15. Hulten LM, Olson FJ, Aberg H, Carlsson J, Karlstrom L, et al. (2010) 15-Lipoxygenase-2 is expressed in macrophages in human carotid plaques and regulated by hypoxia-inducible factor-1alpha. Eur J Clin Invest 40: 11-17.
16. Danielsson KN, Rydberg EK, Ingelsten M, Akyurek LM, Jirholt P, et al. (2008) 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration. Atherosclerosis 199: 34-40.
17. Furstenberger G, Marks F, Krieg P, (2002) Arachidonate 8(S)-lipoxygenase. Prostaglandins Other Lipid Mediat 68-69: 235-243.
18. Jisaka M, Kim RB, Boeglin WE, Brash AR, (2000) Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2. J Biol Chem 275: 1287-1293.
19. Eefting D, Bot I, de Vries MR, Schepers A, van Bockel JH, et al. (2009) Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice. J Vasc Surg 50: 152-160.
20. Frost SC, Lane MD, (1985) Evidence for the involvement of vicinal sulfhydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes. J Biol Chem 260: 2646-2652.
21. Jisaka M, Kim RB, Boeglin WE, Nanney LB, Brash AR, (1997) Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skin. J Biol Chem 272: 24410-24416.
22. Andersson L, Bostrom P, Ericson J, Rutberg M, Magnusson B, et al. (2006) PLD1 and ERK2 regulate cytosolic lipid droplet formation. J Cell Sci 119: 2246-2257.
23. Danielsson KN, Rydberg EK, Ingelsten M, Akyurek LM, Jirholt P, et al. (2008) 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration. Atherosclerosis 199: 34-40.
24. Schweiger D, Furstenberger G, Krieg P, (2007) Inducible expression of 15-lipoxygenase-2 and 8-lipoxygenase inhibits cell growth via common signaling pathways. J Lipid Res 48: 553-564.
25. Upadhya S, Mooteri S, Peckham N, Pai RG, (2004) Atherogenic effect of interleukin-2 and antiatherogenic effect of interleukin-2 antibody in apo-E-deficient mice. Angiology 55: 289-294.
26. Ross R, (1999) Atherosclerosis-an inflammatory disease. N Engl J Med 340: 115-126.
27. Hansson GK, Libby P, Schonbeck U, Yan ZQ, (2002) Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res 91: 281-291.
28. Hansson GK, Libby P, (2006) The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 6: 508-519.
29. Bae J, Park D, Lee YS, Jeoung D, (2008) Interleukin-2 promotes angiogenesis by activation of Akt and increase of ROS. J Microbiol Biotechnol 18: 377-382.
30. Ribatti D, Levi-Schaffer F, Kovanen PT, (2008) Inflammatory angiogenesis in atherogenesis-a double-edged sword. Ann Med 40: 606-621.