Inducible expression of 15-lipoxygenase-2 and 8-lipoxygenase inhibits cell growth via common signaling pathways

Journal of Lipid Research

Volumn 48, Issue 3, 2007, Pages 553-564

  Schweiger, Dorothea ^a   Fürstenberger, Gerhard ^a   Krieg, Peter ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Antioxidant; Keratinocyte; Mitogen activated protein kinases; Reactive oxygen species

Indexed keywords

13 HYDROXYOCTADECADIENOIC ACID; 15 HYDROXYICOSATETRAENOIC ACID; 15 LIPOXYGENASE 2; 8 HYDROXYARACHIDONIC ACID; 9 HYDROXYOCTADECADIENOIC ACID; ARACHIDONATE 8 LIPOXYGENASE; ARACHIDONIC ACID; BAICALEIN; BROXURIDINE; DOXYCYCLINE; HYDROXY FATTY ACID; LINOLEIC ACID; LIPOXYGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DNA SYNTHESIS; GROWTH INHIBITION; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONATE LIPOXYGENASES; ARACHIDONIC ACID; CELL LINE; CELL PROLIFERATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; KERATINOCYTES; LINOLEIC ACID; LIPOXYGENASE INHIBITORS; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 33947168787     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600311-JLR200     Document Type: Article

References (39)

1. Brash, A. R. 1999. Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate. J. Biol. Chem. 274: 23679-23682.
2. Marks, F., and G. Furstenberger. 2000. Cancer chemoprevention through interruption of multistage carcinogenesis. The lessons learnt by comparing mouse skin carcinogenesis and human large bowel cancer. Eur. J. Cancer. 36: 314-329.
3. Uchida, K. 2003. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog. Lipid Res. 42: 318-343.
4. Kuhn, H., and B. J. Thiele. 1999. The diversity of the lipoxygenase family. Many sequence data but little information on biological significance. FEBS Lett. 449: 7-11.
5. Kinzig, A., M. Heidt, G. Fürstenberger, F. Marks, and P. Krieg. 1999. cDNA cloning, genomic structure and chromosomal localization of a novel murine epidermis-type lipoxygenase. Genomics. 58: 158-164.
6. Yu, Z., C. Schneider, W. E. Boeglin, L. J. Marnett, and A. R. Brash. 2003. The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase. Proc. Natl. Acad. Sci. USA. 100: 9162-9167.
7. Krieg, P., M. Heidt, M. Siebert, A. Kinzig, F. Marks, and G. Furstenberger. 2002. Epidermis-type lipoxygenases. Adv. Exp. Med. Biol. 507: 165-170.
8. Krieg, P., F. Marks, and G. Furstenberger. 2001. A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. Genomics. 73: 323-330.
9. Brash, A. R., M. Jisaka, W. E. Boeglin, and M. S. Chang. 1999. Molecular cloning of a second human 15S-lipoxygenase and its murine homologue, an 8S-lipoxygenase. Their relationship to other mammalian lipoxygenases. Adv. Exp. Med. Biol. 447: 29-36.
10. Jisaka, M., R. B. Kim, W. E. Boeglin, L. B. Nanney, and A. R. Brash. 1997. Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skin. J. Biol. Chem. 272: 24410-24416.
11. Krieg, P., A. Kinzig, M. Heidt, F. Marks, and G. Furstenberger. 1998. cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin. Biochim. Biophys. Acta. 1391: 7-12.
12. Brash, A. R., W. E. Boeglin, and M. S. Chang. 1997. Discovery of a second 15S-lipoxygenase in humans. Proc. Natl. Acad. Sci. USA. 94: 6148-6152.
13. Jisaka, M., R. B. Kim, W. E. Boeglin, and A. R. Brash. 2000. Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2. J. Biol. Chem. 275: 1287-1293.
14. Heidt, M., G. Fürstenberger, S. Vogel, F. Marks, and P. Krieg. 2000. Diversity of murine lipoxygenases: identification of a subfamily of epidermal isoenzymes exhibiting a differentiation-dependent mRNA expression pattern. Lipids. 35: 701-707.
15. Shappell, S. B., D. S. Keeney, J. Zhang, R. Page, S. J. Olson, and A. R. Brash. 2001. 15-Lipoxygenase-2 expression in benign and neoplastic sebaceous glands and other cutaneous adnexa. J. Invest. Dermatol. 117: 36-43.
16. Burger, F., P. Krieg, A. Kinzig, B. Schurich, F. Marks, and G. Furstenberger. 1999. Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes. Mol. Carcinog. 24: 108-117.
17. Furstenberger, G., F. Marks, and P. Krieg. 2002. Arachidonate 8(S)-lipoxygenase. Prostaglandins Other Lipid Mediat. 68-69: 235-243.
18. Kilty, I., A. Logan, and P. J. Vickers. 1999. Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. Eur. J. Biochem. 266: 83-93.
19. Strickland, J. E., D. A. Greenhalgh, A. Koceva-Chyla, H. Hennings, C. Restrepo, M. Balaschak, and S. H. Yuspa. 1988. Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts. Cancer Res. 48: 165-169.
20. Tang, S., B. Bhatia, C. J. Maldonado, P. Yang, R. A. Newman, J. Liu, D. Chandra, J. Traag, R. D. Klein, S. M. Fischer, et al. 2002. Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. J. Biol. Chem. 277: 16189-16201.
21. Brash, A. R., W. E. Boeglin, and M. S. Chang. 1997. Discovery of a second 15S-lipoxygenase in humans. Proc. Natl. Acad. Sci. USA. 94: 6148-6152.
22. Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37: 911-917.
23. Powell, W. S. 1982. Rapid extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica. Methods Enzymol. 86: 467-477.
24. Bhatia, B., S. Tang, P. Yang, A. Doll, G. Aumueller, R. A. Newman, and D. G. Tang. 2005. Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cells. Oncogene. 24: 3583-3595.
25. Catalano, A., S. Rodilossi, P. Caprari, V. Coppola, and A. Procopio. 2005. 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation. EMBO J. 24: 170-179.
26. Hsi, L. C., L. C. Wilson, and T. E. Eling. 2002. Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 277: 40549-40556.
27. Nony, P. A., S. B. Kennett, W. C. Glasgow, K. Olden, and J. D. Roberts. 2005. 15S-Lipoxygenase-2 mediates arachidonic acidstimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK. J. Biol. Chem. 280: 31413-31419.
28. Takahashi, Y., W. C. Glasgow, H. Suzuki, Y. Taketani, S. Yamamoto, M. Anton, H. Kuhn, and A. R. Brash. 1993. Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases. Eur. J. Biochem. 218: 165-171.
29. Krieg, P., M. Siebert, A. Kinzig, R. Bettenhausen, F. Marks, and G. Fürstenberger. 1999. Murine 12(R)-lipoxygenase: functional expression, genomic structure and chromosomal localization. FEBS Lett. 446: 142-148.
30. Siebert, M., P. Krieg, W. D. Lehmann, F. Marks, and G. Furstenberger. 2001. Enzymic characterization of epidermis-derived 12-lipoxygenase isoenzymes. Biochem. J. 355: 97-104.
31. Flores, A. M., L. Li, N. G. McHugh, and B. J. Aneskievich. 2005. Enzyme association with PPARgamma: evidence of a new role for 15-lipoxygenase type 2. Chem. Biol. Interact. 151: 121-132.
32. Kim, E., J. E. Rundhaug, F. Benavides, P. Yang, R. A. Newman, and S. M. Fischer. 2005. An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis. Oncogene. 24: 1174-1187.
33. Muga, S. J., P. Thuillier, A. Pavone, J. E. Rundhaug, W. E. Boeglin, M. Jisaka, A. R. Brash, and S. M. Fischer. 2000. 8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes. Cell Growth Differ. 11: 447-454.
34. Chen, G. G., H. Xu, J. F. Lee, M. Subramaniam, K. L. Leung, S. H. Wang, U. P. Chan, and T. C. Spelsberg. 2003. 15-Hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway. Int. J. Cancer. 107: 837-843.
35. Shappell, S. B., R. A. Gupta, S. Manning, R. Whitehead, W. E. Boeglin, C. Schneider, T. Case, J. Price, G. S. Jack, T. M. Wheeler, et al. 2001. 15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells. Cancer Res. 61: 497-503.
36. Chang, M. S., C. Schneider, R. L. Roberts, S. B. Shappell, F. R. Haselton, W. E. Boeglin, and A. R. Brash. 2005. Detection and subcellular localization of two 15S-lipoxygenases in human cornea. Invest. Ophthalmol. Vis. Sci. 46: 849-856.
37. Wakeman, T. P., D. Wyczechowska, and B. Xu. 2005. Involvement of the p38 MAP kinase in Cr(VI)-induced growth arrest and apoptosis. Mol. Cell. Biochem. 279: 69-73.
38. Peus, D., R. A. Vasa, A. Beyerle, A. Meves, C. Krautmacher, and M. R. Pittelkow. 1999. UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J. Invest. Dermatol. 112: 751-756.
39. Lapenna, D., G. Ciofani, S. D. Pierdomenico, M. A. Giamberardino, and F. Cuccurullo. 2003. Dihydrolipoic acid inhibits 15-lipoxygenase-dependent lipid peroxidation. Free Radic. Biol. Med. 35: 1203-1209.