Alkaline phosphatase activity after cardiothoracic surgery in infants and correlation with post-operative support and inflammation: a prospective cohort study

Critical Care

Volumn 16, Issue 4, 2012, Pages

  Davidson, Jesse ^a   Tong, Suhong ^b   Hauck, Amanda ^a   Lawson, D S ^a   Jaggers, James ^a   Kaufman, Jon ^a   da Cruz, Eduardo ^a  

^a CHILDREN S HOSPITAL COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; C REACTIVE PROTEIN; PROCALCITONIN; BIOLOGICAL MARKER; CALCITONIN; CARDIOTONIC AGENT; PROTEIN PRECURSOR;

ARTICLE; CARDIOPULMONARY BYPASS; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DEATH; DELAYED STERNAL CLOSURE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; HEART ARREST; HORMONE BLOOD LEVEL; HOSPITALIZATION; HUMAN; INFANT; INFLAMMATION; INTUBATION; LENGTH OF STAY; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; STATISTICAL MODEL; THORAX SURGERY; ADVERSE EFFECTS; BLOOD; ENDOTRACHEAL INTUBATION; ENZYMOLOGY; HEART SURGERY; METABOLISM; NEWBORN;

ALKALINE PHOSPHATASE; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CALCITONIN; CARDIAC SURGICAL PROCEDURES; CARDIOTONIC AGENTS; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INFLAMMATION; INTUBATION, INTRATRACHEAL; LENGTH OF STAY; MALE; POSTOPERATIVE CARE; PROSPECTIVE STUDIES; PROTEIN PRECURSORS; THORACIC SURGICAL PROCEDURES;

EID: 84865050933     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11483     Document Type: Article

References (26)

1. Van Hoof VO, De Broe ME. Interpretation and clinical significance of alkaline phosphatase isoenzyme patterns. Crit Rev Clin Lab Sci 1994, 31:197-293. 10.3109/10408369409084677, 7818774.
2. Magnusson P, Larsson L, Englund G, Larsson B, Strang P, Selin-Sjogren L. Differences of bone alkaline phosphatase isoforms in metastatic bone disease and discrepant effects of clodronate on different skeletal sites indicated by the location of pain. Clinical ChemistryI 1998, 44:1621-1628.
3. Crofton PM, Hume R. Alkaline phosphatase isoenzymes in the plasma of preterm and term infants: serial measurements and clinical correlations. Clin Chem 1987, 33:1783-1787.
4. Chen KT, Malo MS, Moss AK, Zeller S, Johnson P, Ebrahimi F, Mostafa G, Alam SN, Ramasamy S, Warren HS, Hohmann EL, Hodin RA. Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. Am J Physiol Gastrointest Liver Physiol 2010, 299:G467-475. 10.1152/ajpgi.00364.2009, 2928538, 20489044.
5. Campbell EL, MacManus CF, Kominsky DJ, Keely S, Glover LE, Bowers BE, Scully M, Bruyninckx WJ, Colgan SP. Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification. Proc Natl Acad Sci USA 2010, 107:14298-14303. 10.1073/pnas.0914730107, 2922533, 20660763.
6. Verweij WR, Bentala H, Huizinga-van der Vlag A, Miek van Loenen-Weemaes A, Kooi K, Meijer DK, Poelstra K. Protection against an Escherichia coli-induced sepsis by alkaline phosphatase in mice. Shock 2004, 22:174-179. 10.1097/01.shk.0000132485.05049.8a, 15257092.
7. Lukas M, Drastich P, Konecny M, Gionchetti P, Urban O, Cantoni F, Bortlik M, Duricova D, Bulitta M. Exogenous alkaline phosphatase for the treatment of patients with moderate to severe ulcerative colitis. Inflamm Bowel Dis 2010, 16:1180-1186.
8. Kats S, Brands R, Seinen W, de Jager W, Bekker MW, Hamad MA, Tan ME, Schonberger JP. Anti-inflammatory effects of alkaline phosphatase in coronary artery bypass surgery with cardiopulmonary bypass. Recent Pat Inflamm Allergy Drug Discov 2009, 3:214-220. 10.2174/187221309789257388, 19534671.
9. Kats S, Schonberger JP, Brands R, Seinen W, van Oeveren W. Endotoxin release in cardiac surgery with cardiopulmonary bypass: pathophysiology and possible therapeutic strategies. An update. Eur J Cardiothorac Surg 2011, 39:451-458. 10.1016/j.ejcts.2010.06.011, 20663682.
10. Tuin A, Poelstra K, de Jager-Krikken A, Bok L, Raaben W, Velders MP, Dijkstra G. Role of alkaline phosphatase in colitis in man and rats. Gut 2009, 58:379-387. 10.1136/gut.2007.128868, 18852260.
11. Whitehouse JS, Riggle KM, Purpi DP, Mayer AN, Pritchard KA, Oldham KT, Gourlay DM. The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. J Surg Res 2010, 163:79-85. 10.1016/j.jss.2010.04.048, 20599220.
12. Pickkers P, Snellen F, Rogiers P, Bakker J, Jorens P, Meulenbelt J, Spapen H, Tulleken JE, Lins R, Ramael S, Bulitta M, Van der Hoeven JG. Clinical pharmacology of exogenously administered alkaline phosphatase. Eur J Clin Pharmacol 2009, 65:393-402. 10.1007/s00228-008-0591-6, 19048243.
13. Heemskerk S, Masereeuw R, Moesker O, Bouw MP, van der Hoeven JG, Peters WH, Russel FG, Pickkers P. Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Crit Care Med 2009, 37:417-423. e411, 10.1097/CCM.0b013e31819598af, 19114895.
14. Ebrahimi F, Malo MS, Alam SN, Moss AK, Yammine H, Ramasamy S, Biswas B, Chen KT, Muhammad N, Mostafa G, Warren HS, Hohmann EL, Hodin RA. Local peritoneal irrigation with intestinal alkaline phosphatase is protective against peritonitis in mice. J Gastrointest Surg 2011, 15:860-869. 10.1007/s11605-010-1405-6, 21360208.
15. Raja SG, Dreyfus GD. Modulation of systemic inflammatory response after cardiac surgery. Asian Cardiovasc Thorac Ann 2005, 13:382-395.
16. Klein DJ, Briet F, Nisenbaum R, Romaschin AD, Mazer CD. Endotoxemia related to cardiopulmonary bypass is associated with increased risk of infection after cardiac surgery: a prospective observational study. Crit Care 2011, 15:R69. 10.1186/cc10051, 3222002, 21345192.
17. Ascione R, Talpahewa S, Rajakaruna C, Reeves BC, Lovell AT, Cohen A, Angelini GD. Splanchnic organ injury during coronary surgery with or without cardiopulmonary bypass: a randomized, controlled trial. Ann Thorac Surg 2006, 81:97-103. 10.1016/j.athoracsur.2005.06.038, 16368344.
18. Lum G, Marquardt C, Khuri SF. Hypomagnesemia and low alkaline phosphatase activity in patients' serum after cardiac surgery. Clin Chem 1989, 35:664-667.
19. Neutze JM, Drakeley MJ, Barratt-Boyes BG. Serum enzymes after cardiac surgery under profound hypothermia with circulatory arrest and limited cardiopulmonary bypass. Am Heart J 1974, 88:553-556. 10.1016/0002-8703(74)90237-3, 4421995.
20. Jacobs ML, Jacobs JP, Jenkins KJ, Gauvreau K, Clarke DR, Lacour-Gayet F. Stratification of complexity: the Risk Adjustment for Congenital Heart Surgery-1 method and the Aristotle Complexity Score--past, present, and future. Cardiol Young 2008, 18(Suppl 2):163-168.
21. Lacour-Gayet F, Clarke D, Jacobs J, Gaynor W, Hamilton L, Jacobs M, Maruszewski B, Pozzi M, Spray T, Tchervenkov C, Mavroudis C. The Aristotle score for congenital heart surgery. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2004, 7:185-191. 10.1053/j.pcsu.2004.02.011, 15283368.
22. Gaies MG, Gurney JG, Yen AH, Napoli ML, Gajarski RJ, Ohye RG, Charpie JR, Hirsch JC. Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med 2010, 11:234-238. 10.1097/PCC.0b013e3181b806fc, 19794327.
23. Pickkers P, Heemskerk S, Schouten J, Laterre PF, Vincent JL, Beishuizen A, Jorens PG, Spapen H, Bulitta M, Peters WH, Van der Hoeven JG. Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial. Crit Care 2012, 16:R14. 10.1186/cc11159, 3396250, 22269279.
24. Beghetti M, Rimensberger PC, Kalangos A, Habre W, Gervaix A. Kinetics of procalcitonin, interleukin 6 and C-reactive protein after cardiopulmonary-bypass in children. Cardiol Young 2003, 13:161-167. 10.1017/S1047951103000301, 12887072.
25. Crespo-Marcos D, Rey-Galan C, Lopez-Herce-Cid J, Crespo-Hernandez M, Concha-Torre A, Perez-Solis D. Kinetics of C-reactive protein and procalcitonin after paediatric cardiac surgery. An Pediatr (Barc) 2010, 73:162-168. Article in Spanish.
26. Los Arcos M, Rey C, Concha A, Medina A, Prieto B. Acute-phase reactants after paediatric cardiac arrest. Procalcitonin as marker of immediate outcome. BMC Pediatr 2008, 8:18. 10.1186/1471-2431-8-18, 2386781, 18447945.