Activation of PPARγ by restores mast cell numbers and reactivity in alloxan-diabetic rats by reducing the systemic glucocorticoid levels

European Journal of Pharmacology

Volumn 691, Issue 1-3, 2012, Pages 261-267

  Torres, Rafael C ^a   Batista, Marcelo M ^b   Pons, Andrea H ^b   Silva, Adriana R ^c   Cordeiro, Renato S B ^a   Martins, Marco A ^a   E Silva, Patrícia M R ^a   Carvalho, Vinicius F ^a  

^a Laboratório de Inflamação   (Brazil)

^b Laboratório de Inovação em Terapias   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Apoptosis; Diabetes; Glucocorticoids; Mast cells; PPAR

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CORTICOSTERONE; GLUCOCORTICOID; HISTAMINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE;

ALLOXAN DIABETES MELLITUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DIABETES MELLITUS; DIET RESTRICTION; DRUG MECHANISM; FLUORESCENCE ANALYSIS; HISTAMINE RELEASE; IMMUNOREACTIVITY; IN VITRO STUDY; MALE; MAST CELL; MESENTERIC TISSUE; NICK END LABELING; NONHUMAN; PLEURA CAVITY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; TISSUE SECTION; TREATMENT DURATION;

ANIMALS; APOPTOSIS; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CUSHING SYNDROME; DIABETES MELLITUS, EXPERIMENTAL; GLUCOCORTICOIDS; MALE; MAST CELLS; PPAR GAMMA; RATS; RATS, WISTAR; THIAZOLIDINEDIONES;

EID: 84865045528     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.06.010     Document Type: Article

References (40)

1. B. Ambrosi, C. Dall'Asta, S. Cannavo, R. Libe, T. Vigo, P. Epaminonda, I. Chiodini, S. Ferrero, F. Trimarchi, M. Arosio, and P. Beck-Peccoz Effects of chronic administration of PPAR-gamma ligand rosiglitazone in Cushing's disease Eur. J. Endocrinol. 151 2004 173 178 (Pubitemid 39207011)
2. W. Arlt, R.J. Auchus, and W.L. Miller Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase J. Biol. Chem. 276 2001 16767 16771
3. P. Augstein, A. Dunger, P. Heinke, G. Wachlin, S. Berg, B. Hehmke, and E. Salzsieder Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells Biochem. Biophys. Res. Commun. 304 2003 378 384 (Pubitemid 36444581)
4. W.M. Awara, A.E. el-Sisi, M. el-Refaei, M.M. el-Naa, and K. el-Desoky Insulinotropic and anti-inflammatory effects of rosiglitazone in experimental autoimmune diabetes Rev. Diabet. Stud. 2 2005 146 156
5. E.O. Barreto, V.F. Carvalho, V. Lagente, C. Lugnier, R.S. Cordeiro, M.A. Martins, and E.S. PM Increased levels of cyclic adenosine monophosphate contribute to the hyporesponsiveness of mast cells in alloxan diabetes Int. Immunopharmacol. 4 2004 755 762 (Pubitemid 38595532)
6. E.O. Barreto, V.F. Carvalho, M.S. Oliveira, A.L. Bertho, T.C. Barja-Fidalgo, R.S. Cordeiro, M.A. Martins, and P.M. e Silva High levels of filamentous actin and apoptosis correlate with mast cell refractoriness under alloxan-evoked diabetes Life Sci. 79 2006 1194 1202 (Pubitemid 44128580)
7. F. Biscetti, G. Straface, V. Arena, E. Stigliano, G. Pecorini, P. Rizzo, G. De Angelis, L. Iuliano, G. Ghirlanda, and A. Flex Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation Cardiovasc Diabetol. 8 2009 49 56
8. M. Cakir, S. Akcay, T. Karakas, Y. Gedik, A. Okten, and F. Orhan Prevalence of atopy in children with type 1 diabetes mellitus, hepatitis B virus carriers, and healthy children: role of T helper 1 (Th1)-type immune response Allergy Asthma Proc. 29 2008 166 170
9. V.F. Carvalho, E.O. Barreto, M.F. Serra, R.S. Cordeiro, M.A. Martins, Z.B. Fortes, and P.M. e Silva Aldose reductase inhibitor zopolrestat restores allergic hyporesponsiveness in alloxan-diabetic rats Eur. J. Pharmacol. 549 2006 173 178 (Pubitemid 44444912)
10. V.F. Carvalho, L.T. Florim, O.B.E. de, R.C. Torres, M.M. Batista, F.C. Amendoeira, R.S. Cordeiro, M.A. Martins, and E.S. PM Inhibition of advanced glycation end products by aminoguanidine restores mast cell numbers and reactivity in alloxan-diabetic rats Eur. J. Pharmacol. 669 2011 143 148
11. P.M. Catalano, S.E. Nizielski, J. Shao, L. Preston, L. Qiao, and J.E. Friedman Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy Am. J. Physiol. Endocrinol. Metab. 282 2002 E522 E533
12. O. Chan, K. Inouye, M. Vranic, and S.G. Matthews Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity Endocrinology 143 2002 1761 1768 (Pubitemid 34415891)
13. N. Cho, and Y. Momose Peroxisome proliferator-activated receptor gamma agonists as insulin sensitizers: from the discovery to recent progress Curr. Top. Med. Chem. 8 2008 1483 1507
14. L.F. de Souza, F. Barreto, E.G. da Silva, M.E. Andrades, E.L. Guimaraes, G.A. Behr, J.C. Moreira, and E.A. Bernard Regulation of LPS stimulated ROS production in peritoneal macrophages from alloxan-induced diabetic rats: involvement of high glucose and PPARgamma Life Sci. 81 2007 153 159 (Pubitemid 46921179)
15. B.L. Diaz, M.F. Serra, A.C. Alves, A.L. Pires, F.M. Correa, R.S. Cordeiro, M.A. Martins, and P. e Silva Alloxan diabetes reduces pleural mast cell numbers and the subsequent eosinophil influx induced by allergen in sensitized rats Int. Arch Allergy Immunol. 111 1996 36 43 (Pubitemid 26334635)
16. e P.M. Silva, V.F. Carvalho, R.S. Cordeiro, and M.A. Martins Down-regulation of allergic responses in conditions of experimental diabetes: a role for glucocorticoids? Neuroimmunomodulation 16 2009 13 18
17. W.H. Fong, H.D. Tsai, Y.C. Chen, J.S. Wu, and T.N. Lin Anti-apoptotic actions of PPAR-gamma against ischemic stroke Mol. Neurobiol. 41 2010 180 186
18. B.M. Forman, J. Chen, and R.M. Evans Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta Proc. Natl. Acad. Sci., USA 94 1997 4312 4317 (Pubitemid 27194238)
19. K. Fuenzalida, R. Quintanilla, P. Ramos, D. Piderit, R.A. Fuentealba, G. Martinez, N.C. Inestrosa, and M. Bronfman Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis J. Biol. Chem. 282 2007 37006 37015
20. A.P. Heaney, M. Fernando, W.H. Yong, and S. Melmed Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas Nat. Med. 8 2002 1281 1287 (Pubitemid 35373561)
21. S.J. Holdsworth-Carson, R. Lim, A. Mitton, C. Whitehead, G.E. Rice, M. Permezel, and M. Lappas Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsia Placenta 31 2010 222 229
22. H. Ikeda, S. Taketomi, Y. Sugiyama, Y. Shimura, T. Sohda, K. Meguro, and T. Fujita Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals Arzneimittelforschung 40 1990 156 162 (Pubitemid 20071860)
23. N. Kanie, T. Matsumoto, T. Kobayashi, and K. Kamata Relationship between peroxisome proliferator-activated receptors (PPAR alpha and PPAR gamma) and endothelium-dependent relaxation in streptozotocin-induced diabetic rats Br. J. Pharmacol. 140 2003 23 32 (Pubitemid 37175827)
24. M. Kusunoki, K. Tsutsumi, D. Sato, A. Nakamura, S. Habu, Y. Mori, M. Morishita, T. Yonemoto, T. Miyata, Y. Nakaya, and T. Nakamura Pioglitazone-induced body weight gain is prevented by combined administration with the lipoprotein lipase activator NO-1886 Eur. J. Pharmacol. 668 2011 486 491
25. S. Lim, C.J. Jin, M. Kim, S.S. Chung, H.S. Park, I.K. Lee, C.T. Lee, Y.M. Cho, H.K. Lee, and K.S. Park PPARgamma gene transfer sustains apoptosis, inhibits vascular smooth muscle cell proliferation, and reduces neointima formation after balloon injury in rats Arterioscler. Thromb. Vasc. Biol. 26 2006 808 813 (Pubitemid 43732155)
26. T.N. Lin, W.M. Cheung, J.S. Wu, J.J. Chen, H. Lin, J.Y. Liou, S.K. Shyue, and K.K. Wu 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury Arterioscler. Thromb. Vasc. Biol. 26 2006 481 487
27. H.B. Liu, Y.S. Hu, R.L. Medcalf, R.W. Simpson, and A.E. Dear Thiazolidinediones inhibit TNFalpha induction of PAI-1 independent of PPARgamma activation Biochem. Biophys. Res. Commun. 334 2005 30 37 (Pubitemid 40978503)
28. K. Maeyama, M. Emi, and M. Tachibana Nuclear receptors as targets for drug development: peroxisome proliferator-activated receptor gamma in mast cells: its roles in proliferation and differentiation J. Pharmacol. Sci. 97 2005 190 194 (Pubitemid 40410258)
29. M.F. Mitwally, S.F. Witchel, and R.F. Casper Troglitazone: a possible modulator of ovarian steroidogenesis J. Soc. Gynecol. Investig. 9 2002 163 167 (Pubitemid 34497145)
30. O. Oz Gul, E. Tuncel, Y. Yilmaz, E. Ulukaya, C.B. Gul, S. Kiyici, A.Y. Oral, M. Guclu, C. Ersoy, and S. Imamoglu Comparative effects of pioglitazone and rosiglitazone on plasma levels of soluble receptor for advanced glycation end products in type 2 diabetes mellitus patients Metabolism 59 2010 64 69
31. C.W. Shiau, C.C. Yang, S.K. Kulp, K.F. Chen, C.S. Chen, and J.W. Huang Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma Cancer Res. 65 2005 1561 1569 (Pubitemid 40270186)
32. P.A. Shore, A. Burkhalter, and V.H. Cohn Jr. A method for the fluorometric assay of histamine in tissues J. Pharmacol. Exp. Ther. 127 1959 182 186
33. H. Sugiyama, T. Nonaka, T. Kishimoto, K. Komoriya, K. Tsuji, and T. Nakahata Peroxisome proliferator-activated receptors are expressed in human cultured mast cells: a possible role of these receptors in negative regulation of mast cell activation Eur. J. Immunol. 30 2000 3363 3370 (Pubitemid 32005206)
34. N. Taleb, P. Bou Khalil, M.S. Zantout, P. Zalloua, and S.T. Azar Prevalence of asthmatic symptoms in Lebanese patients with type 1 diabetes and their unaffected siblings compared to age-matched controls Acta Diabetol. 47 2010 13 18
35. F. Turturro, R. Oliver 3rd, E. Friday, I. Nissim, and T. Welbourne Troglitazone and pioglitazone interactions via PPAR-gamma-independent and -dependent pathways in regulating physiological responses in renal tubule-derived cell lines Am. J. Physiol. Cell Physiol. 292 2007 C1137 1146
36. T.L. van Belle, K.T. Coppieters, and M.G. von Herrath Type 1 diabetes: etiology, immunology, and therapeutic strategies Physiol. Rev. 91 2011 79 118
37. F. Wang, L. Gao, B. Gong, J. Hu, M. Li, Q. Guan, and J. Zhao Tissue-specific expression of PPAR mRNAs in diabetic rats and divergent effects of cilostazol Can. J. Physiol. Pharmacol. 86 2008 465 471 (Pubitemid 351948686)
38. N.S. Yaacob, M.A. Kaderi, and M.N. Norazmi Differential transcriptional expression of PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages and T-cell subsets of non-obese diabetic mice J. Clin. Immunol. 29 2009 595 602
39. M. Yamashita, M. Kushihara, N. Hirasawa, W. Takasaki, H. Takahagi, M. Takayanagi, and K. Ohuchi Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells Br. J. Pharmacol. 129 2000 367 373 (Pubitemid 30072658)
40. K.J. Yang, J.R. Noh, Y.H. Kim, G.T. Gang, J.H. Hwang, S.J. Yang, Y.I. Yeom, and C.H. Lee Differential modulatory effects of rosiglitazone and pioglitazone on white adipose tissue in db/db mice Life Sci. 87 2010 405 410