Performance on a probabilistic inference task in healthy subjects receiving ketamine compared with patients with schizophrenia

Journal of Psychopharmacology

Volumn 26, Issue 9, 2012, Pages 1211-1217

  Evans, Simon ^a   Almahdi, Basil ^b   Sultan, Pervez ^b   Sohanpal, Imrat ^b   Brandner, Brigitta ^b   Collier, Tracey ^c   Shergill, Sukhi S ^c   Cregg, Roman ^b   Averbeck, Bruno B ^a,d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

decision making; Ketamine; schizophrenia

Indexed keywords

KETAMINE;

ADULT; ARTICLE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DECISION MAKING; FEMALE; HUMAN; MALE; MENTAL PERFORMANCE; MENTAL TASK; PRIORITY JOURNAL; PROBABILISTIC INFERENCE TASK; SCHIZOPHRENIA;

ADULT; ANESTHETICS, DISSOCIATIVE; ANTIPSYCHOTIC AGENTS; DECISION MAKING; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HUMANS; KETAMINE; MALE; MIDDLE AGED; NEUROTOXICITY SYNDROMES; PATIENT DROPOUTS; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEVERITY OF ILLNESS INDEX; TASK PERFORMANCE AND ANALYSIS; YOUNG ADULT;

EID: 84865043990     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881111435252     Document Type: Article

References (51)

1. Adler CM, Goldberg TE, Malhotra AK, et al. Effects of ketamine on thought disorder, working memory, and semantic memory in healthy volunteers. Biol Psychiatry. 1998 ; 43: 811-816
2. Adler CM, Malhotra AK, Elman I, et al. Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia. Am J Psychiatry. 1999 ; 156: 1646-1649
3. Averbeck BB, Evans S, Chouhan V, et al. Probabilistic learning and inference in schizophrenia. Schizophr Res. 2011 ; 127: 115-122
4. Breier A, Adler CM, Weisenfeld N, et al. Effects of NMDA antagonism on striatal dopamine release in healthy subjects: application of a novel PET approach. Synapse. 1998 ; 29: 142-147
5. Broome MR, Johns LC, Valli I, et al. Delusion formation and reasoning biases in those at clinical high risk for psychosis. Br J Psychiatry Suppl. 2007 ; 51: s38 - s42
6. Corlett PR, Honey GD, Aitken MR, et al. Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis. Arch Gen Psychiatry. 2006 ; 63: 611-621
7. Domino EF, Domino SE, Smith RE, et al. Ketamine kinetics in unmedicated and diazepam-premedicated subjects. Clin Pharmacol Ther. 1984 ; 36: 645-653
8. Dudley RE, John CH, Young AW, et al. Normal and abnormal reasoning in people with delusions. Br J Clin Psychol. 1997 ; 36 (Pt 2). 243-258
9. Fine C, Gardner M, Craigie J, et al. Hopping, skipping or jumping to conclusions? Clarifying the role of the JTC bias in delusions. Cogn Neuropsychiatry. 2007 ; 12: 46-77
10. Freeman TP, Morgan CJ, Klaassen E, et al. Superstitious conditioning as a model of delusion formation following chronic but not acute ketamine in humans. Psychopharmacology. 2009 ; 206: 563-573
11. Garety P. Reasoning and delusions. Br J Psychiatry Suppl. 1991 ; 14: 14-18
12. Garety PA, Freeman D. Cognitive approaches to delusions: a critical review of theories and evidence. Br J Clin Psychol. 1999 ; 38 (Pt 2). 113-154
13. Garety PA, Hemsley DR, Wessely S. Reasoning in deluded schizophrenic and paranoid patients. Biases in performance on a probabilistic inference task. J Nerv Ment Dis. 1991 ; 179: 194-201
14. Glöckner A, Moritz S. A fine-grained analysis of the jumping to conclusions bias in schizophrenia: data-gathering, response confidence, and information integration. Judgment Decis Making. 2009 ; 4: 587-600
15. Gray JA. Dopamine release in the nucleus accumbens: the perspective from aberrations of consciousness in schizophrenia. Neuropsychologia. 1995 ; 33: 1143-1153
16. Gray NS, Snowden RJ. The relevance of irrelevance to schizophrenia. Neurosci Biobehav Rev. 2005 ; 29: 989-999
17. Hemsley DR. The development of a cognitive model of schizophrenia: placing it in context. Neurosci Biobehav Rev. 2005 ; 29: 977-988
18. Honey GD, Corlett PR, Absalom AR, et al. Individual differences in psychotic effects of ketamine are predicted by brain function measured under placebo. J Neurosci. 2008 ; 28: 6295-6303
19. Honey RA, Turner DC, Honey GD, et al. Subdissociative dose ketamine produces a deficit in manipulation but not maintenance of the contents of working memory. Neuropsychopharmacology. 2003 ; 28: 2037-2044
20. Huq SF, Garety PA, Hemsley DR. Probabilistic judgements in deluded and non-deluded subjects. Q J Exp Psychol A. 1988 ; 40: 801-812
21. Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry. 2003 ; 160: 13-23
22. Kapur S. How antipsychotics become anti-"psychotic"-from dopamine to salience to psychosis. Trends Pharmacol Sci. 2004 ; 25: 402-406
23. Kapur S, Mizrahi R, Li M. From dopamine to salience to psychosis-linking biology, pharmacology and phenomenology of psychosis. Schizophr Res. 2005 ; 79: 59-68
24. Kapur S, Seeman P. NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia. Mol Psychiatry. 2002 ; 7: 837-844
25. Kemp R, Chua S, McKenna P, et al. Reasoning and delusions. Br J Psychiatry. 1997 ; 170: 398-405
26. Krystal JH, Bennett A, Abi-Saab D, et al. Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions. Biol Psychiatry. 2000 ; 47: 137-143
27. Krystal JH, Karper LP, Seibyl JP, et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry. 1994 ; 51: 199-214
28. Lahti AC, Holcomb HH, Medoff DR, et al. Ketamine activates psychosis and alters limbic blood flow in schizophrenia. Neuroreport. 1995 ; 6: 869-872
29. Lahti AC, Weiler MA, Tamara Michaelidis BA, et al. Effects of ketamine in normal and schizophrenic volunteers. Neuropsychopharmacology. 2001 ; 25: 455-467
30. Lavin A, Nogueira L, Lapish CC, et al. Mesocortical dopamine neurons operate in distinct temporal domains using multimodal signaling. J Neurosci. 2005 ; 25: 5013-5023
31. Linney YM, Peters ER, Ayton P. Reasoning biases in delusion-prone individuals. Br J Clin Psychol. 1998 ; 37 (Pt 3). 285-302
32. McKenna PJ Therapeutic Strategies in Schizophrenia. Mortimer AM McKenna PJ, ed. Oxford: Clinical Publishing ; 2010 :
33. Malhotra AK, Pinals DA, Adler CM, et al. Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics. Neuropsychopharmacology. 1997 ; 17: 141-150
34. Malhotra AK, Pinals DA, Weingartner H, et al. NMDA receptor function and human cognition: the effects of ketamine in healthy volunteers. Neuropsychopharmacology. 1996 ; 14: 301-307
35. Menon M, Mizrahi R, Kapur S. 'Jumping to conclusions' and delusions in psychosis: relationship and response to treatment. Schizophr Res. 2008 ; 98: 225-231
36. Menon M, Pomarol-Clotet E, McKenna PJ, et al. Probabilistic reasoning in schizophrenia: a comparison of the performance of deluded and nondeluded schizophrenic patients and exploration of possible cognitive underpinnings. Cogn Neuropsychiatry. 2006 ; 11: 521-536
37. Moghaddam B, Adams B, Verma A, et al. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci. 1997 ; 17: 2921-2927
38. Morgan CJ, Muetzelfeldt L, Curran HV. Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex-users with polydrug and non-using controls. Addiction. 2009 ; 104: 77-87
39. Moritz S, Woodward TS. Jumping to conclusions in delusional and non-delusional schizophrenic patients. Br J Clin Psychol. 2005 ; 44: 193-207
40. Mortimer AM, Bentham P, McKay AP, et al. Delusions in schizophrenia: A phenomenological and psychological exploration. Cogn Neuropsychiatry. 1996 ; 1: 289-304
41. Newcomer JW, Krystal JH. NMDA receptor regulation of memory and behavior in humans. Hippocampus. 2001 ; 11: 529-542
42. Patil ST, Zhang L, Martenyi F, et al. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial. Nat Med. 2007 ; 13: 1102-1107
43. Payne JW, Bettman JR, Johnson EJ. Adaptive strategy selection in decision making. J Exp Psychol Learn Memory Cognit. 1988 ; 14: 534-552
44. Peters E, Garety P. Cognitive functioning in delusions: a longitudinal analysis. Behav Res Ther. 2006 ; 44: 481-514
45. Phillips LD, Edwards W. Conservatism in a simple probability inference task. J Exp Psychol. 1966 ; 72: 346-354
46. Pomarol-Clotet E, Honey GD, Murray GK, et al. Psychological effects of ketamine in healthy volunteers. Phenomenological study. B J Psychiatry. 2006 ; 189: 173-179
47. Schultz W. Getting formal with dopamine and reward. Neuron. 2002 ; 36: 241-263
48. Shafer SL, Varvel JR, Aziz N, et al. Pharmacokinetics of fentanyl administered by computer-controlled infusion pump. Anesthesiology. 1990 ; 73: 1091-1102
49. Stefanovic A, Brandner B, Klaassen E, et al. Acute and chronic effects of ketamine on semantic priming: modeling schizophrenia?. J Clin Psychopharmacol. 2009 ; 29: 124-133
50. Van Dael F, Versmissen D, Janssen I, et al. Data gathering: biased in psychosis?. Schizophr Bull. 2006 ; 32: 341-351
51. Vollenweider FX, Vontobel P, Oye I, et al. Effects of (S)-ketamine on striatal dopamine: a [11C]raclopride PET study of a model psychosis in humans. J Psychiatr Res. 2000 ; 34: 35-43