IgF M-components in active myeloma patients induce a down-regulation of natural killer cell activity

International Journal of Clinical and Laboratory Research

Volumn 27, Issue 1, 1997, Pages 48-54

  Frassanito, M A ^a   Silvestris, F ^a   Cafforio, P ^a   Silvestris, N ^a   Dammacco, F ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Fc RIII; M component; Multiple myeloma; Natural killer ceils

Indexed keywords

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; TUMOR MARKER;

ADULT; AGED; ARTICLE; BLOOD; CELL MEMBRANE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOWN REGULATION; HUMAN; IMMUNOLOGY; MIDDLE AGED; MULTIPLE MYELOMA; NATURAL KILLER CELL;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; CELL MEMBRANE; DOWN-REGULATION; HUMANS; IMMUNOGLOBULIN G; KILLER CELLS, NATURAL; MIDDLE AGED; MULTIPLE MYELOMA; TUMOR MARKERS, BIOLOGICAL;

EID: 0030612553     PISSN: 09405437     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02827242     Document Type: Article

References (26)

1. Trinchieri G. Biology of natural killer cells. Adv Immunol 1989; 47: 187.
2. Perussia B, Acuto O, Terhorst C, Faust J, Lazarus R, Fanning V, Trinchieri G. Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking FcR functions. Studies of B73.1 antibody-antigen interaction on the lymphocyte membrane. J Immunol 1983; 130: 2142.
3. Trinchieri G, O'Brien T, Shada M, Perussia B. Phorbol esters enhance spontaneous cytotoxicity of human lymphocytes, abrogate Fc receptor expression, and inhibit antibody-dependent lymphocytes-mediated cytotoxicity. I Immunol 1984; 133: 1869.
4. Lanier LL, Phillips JH, Testi R. Membrane anchoring and spontaneous release of CD16 (FcRIII) by natural killer cells and granulocytes. Eur J Immunol 1989; 19: 775.
5. Sulica A, Gherman M, Galatiuc C, Manciulea M, Herberman RB. Inhibition of human natural killer cell activity by cytophilic immunoglobulin G. J Immunol 1982; 128: 1031.
6. Gherman M, Manciulea M, Bancu AC, Sulica A, Stanworth DR, Herberman RB. Regulation of human natural cytotoxicity by IgG. I. Characterization of the structural site on monomeric IgG responsible for inhibiting natural killer cell activity. Mol Immunol 1987; 24: 743.
7. Bancu AC, Gherman M, Sulica A, Goto T, Farrar W, Herberman RB. Regulation of human natural cytotoxicity by IgG. II. Cyclic AMP as a mediator of monomeric IgG-induced inhibition of natural killer cell activity. Cell Immunol 1988; 114: 246.
8. Sulica A, Gherman M, Manciulea M, Galatiuc C, Herberman RB. Regulation of human natural cytotoxicity by IgG. III. Interaction between interferons of different types Nat Immun Cell Growth Regul 1989; 8: 266.
9. Wilson AB, Coombs RRA. Fcγ-receptor bearing, non B lymphocytes in human peripheral blood: cytophilic immunoglobulin binds almost exclusively to large granular lymphocytes. Cell Immunol 1985; 90: 196.
10. Vaickus L, Robinson M, Lynch RG. Analysis of human peripheral blood mononuclear cells bearing Fc receptors for the three major immunoglobulin isotypes. Clin Immunol Immunopathol 1988; 47: 106.
11. Engelhard D, Werner JL, Kafoor M, Good R. Effect of intravenous immunoglobulin on natural killer cell activity: possible association with autoimmune neutropenia and idiopathic thrombocytopenia. J Pediatr 1986; 108: 77.
12. Koren HS, Amos DB, Buckley RM. Natural killing in immunodeficient patients. J Immunol 1978; 120: 796.
13. Pross NK, Gupta S, Good RA, Beines MG. Spontaneous human lymphocyte-mediating cytotoxicity against target cells. Cell Immunol 1979; 43: 160.
14. Uchida A, Yagita M, Sugiyama H, Hoshino T, Moore M. Strong natural killer (NK) cell activity in bone marrow of myeloma patients: accelerated maturation of bone marrow NK cells and their interaction with other bone marrow cells. Int J Cancer 1984; 34: 375.
15. Ögmundsdóttir HM. Natural killer cell activity in patients with multiple myeloma. Cancer Detect Prev 1988; 12: 133.
16. Österborg A, Nilsson B, Björkholm M, Holm G, Mellstedt H. Natural killer cell activity in monoclonal gammopathies: relation to disease activity. Eur J Haematol 1990; 45: 153.
17. Famularo G, D'Ambrosio A, Quintieri F, Di Giovanni S, Parzanese I, Pizzuto F, Giacomelli R, Pugliese O, Tonietti G. Natural killer cell frequency and function in patients with monoclonal gammopathies. J Clin Lab Immunol 1992; 37: 99.
18. Gonzales M, San Miguel JF, Gascon A, Moro MJ, Hernandez JM, Ortega F, Jimenez R, Guerras L, Romero M, Casanova F. Increased expression of natural killer-associated and activation antigens in multiple myeloma. Am J Hematol 1992; 39: 84.
19. García-Sanz R, Gonzáles M, Orfao A, Moro MJ, Hernandez JM, Borrego D, Carnero M, Casanova F, Barez A, Jimenez R, San Miguel J. Analysis of natural killer-associated antigens in peripheral blood and bone marrow of multiple myeloma patients and prognostic implications. Brit J Haematol 1996; 93: 81.
20. Durie BMG, Salmon SE. Multiple myeloma, macroglobulinemia and monoclonal gammopathies. In: Hoffbrand AV, Brain MC, Hirsh J, eds. Recent advances in haematology. New York: Churchill Livingstone; 1977: 243.
21. Durie BMG, Russel D, Salmon SE. Reappraisal of the plateau-phase myeloma. Lancet 1980; II: 65.
22. Coligan EJ, Kruisbeek AM, Margulies DH, Shevach EM, Strober W. Immunologic studies in humans In: Coligan EJ, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, eds. Current protocols in immunology. New York: Green and Wiley; 1994: 7.18.
23. Nielsen H, Nielsen HJ, Tvede N, Klarlund R, Mansa B, Moesgaard F, Drivsholm A. Immune dysfunction in multiple myeloma. Reduced natural killer cell activity and increased levels of soluble interleukin-2 receptors APMIS 1991; 99: 340.
24. Warren HS, Skipsey LJ Phenotypic analysis of a resting subpopulation of human peripheral blood NK cells: the FcRγIII (CD16) molecule and NK cell differentiation. Immunology 1991; 72: 150.
25. Vacca A, Di Stefano R, Frassanito A, Iodice G, Dammacco F. A disturbance of the IL-2/IL-2 receptor system parallels the activity of multiple myeloma. Clin Exp Immunol 1991; 84: 429.
26. Montel AH, Bochan MR, Obbs JA, Lynch DH, Brahmi Z. Fas involvement in cytotoxicity mediated by human NK cells. Cell Immunol 1995; 166: 236.