IL-36 in psoriasis

Current Opinion in Pharmacology

Volumn 12, Issue 4, 2012, Pages 486-490

  Towne, Je ^a   Sims, Je ^b  

^a AMGEN INC   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 36; INTERLEUKIN 36 RECEPTOR A; INTERLEUKIN 36ALPHA; INTERLEUKIN 36BETA; INTERLEUKIN 36GAMMA; INTERLEUKIN 6; INTERLEUKIN 8; MATRIX METALLOPROTEINASE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN S 100; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR INHIBITOR; UNCLASSIFIED DRUG;

BRAIN TISSUE; CELL STIMULATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; FEEDBACK SYSTEM; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; INTESTINE; KERATINOCYTE; KIDNEY PARENCHYMA; LUNG PARENCHYMA; LYMPHOCYTE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PSORIASIS; REGULATORY MECHANISM; REVIEW; SYNOVIUM;

EID: 84865017138     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2012.02.009     Document Type: Review

References (24)

1. J.E. Sims, and D.E. Smith The IL-1 family: regulators of immunity Nat Rev Immunol 10 2010 89 102
2. J.E. Towne, K.E. Garka, B.R. Renshaw, G.D. Virca, and J.E. Sims Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs J Biol Chem 279 2004 13677 13688
3. J.E. Towne, B.R. Renshaw, J. Douangpanya, B.P. Lipsky, M. Shen, C.A. Gabel, and J.E. Sims Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity J Biol Chem 286 2011 42594 42602
4. F.O. Nestle, D.H. Kaplan, and J. Barker Psoriasis N Engl J Med 361 2009 496 509
5. R. Debets, J.C. Timans, B. Homey, S. Zurawski, T.R. Sana, S. Lo, J. Wagner, G. Edwards, T. Clifford, and S. Menon Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2 J Immunol 167 2001 1440 1446
6. H. Blumberg, H. Dinh, E.S. Trueblood, J. Pretorius, D. Kugler, N. Weng, S.T. Kanaly, J.E. Towne, C.R. Willis, and M.K. Kuechle Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation J Exp Med 204 2007 2603 2614
7. X. Zhou, J.G. Krueger, M.C. Kao, E. Lee, F. Du, A. Menter, W.H. Wong, and A.M. Bowcock Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array Physiol Genomics 13 2003 69 78
8. H. Blumberg, H. Dinh, C. Dean Jr., E.S. Trueblood, K. Bailey, D. Shows, N. Bhagavathula, M.N. Aslam, J. Varani, and J.E. Towne IL-1RL2 and its ligands contribute to the cytokine network in psoriasis J Immunol 185 2010 4354 4362
9. A. Johnston, X. Xing, A.M. Guzman, M. Riblett, C.M. Loyd, N.L. Ward, C. Wohn, E.P. Prens, F. Wang, and L.E. Maier IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression J Immunol 186 2011 2613 2622
10. Y. Carrier, H.L. Ma, H.E. Ramon, L. Napierata, C. Small, M. O'Toole, D.A. Young, L.A. Fouser, C. Nickerson-Nutter, and M. Collins Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis J Invest Dermatol 131 2011 2428 2437
11. P. Muhr, J. Zeitvogel, I. Heitland, T. Werfel, and M. Wittmann Expression of interleukin (IL)-1 family members upon stimulation with IL-17 differs in keratinocytes derived from patients with psoriasis and healthy donors Br J Dermatol 165 2011 189 193
12. S. Vigne, G. Palmer, C. Lamacchia, P. Martin, D. Talabot-Ayer, E. Rodriguez, F. Ronchi, F. Sallusto, H. Dinh, and J.E. Sims IL-36R ligands are potent regulators of dendritic and T cells Blood 118 2011 5813 5823
13. S. Mutamba, A. Allison, Y. Mahida, P. Barrow, and N. Foster Expression of IL-1Rrp2 by human myelomonocytic cells is unique to DCs and facilitates DC maturation by IL-1F8 and IL-1F9 Eur J Immunol 42 2012 607 617 10.1002/eji.201142035 [Epub ahead of print]
14. S. Marrakchi, P. Guigue, B.R. Renshaw, A. Puel, X.Y. Pei, S. Fraitag, J. Zribi, E. Bal, C. Cluzeau, and M. Chrabieh Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis N Engl J Med 365 2011 620 628
15. A. Onoufriadis, M.A. Simpson, A.E. Pink, P. Di Meglio, C.H. Smith, V. Pullabhatla, J. Knight, S.L. Spain, F.O. Nestle, and A.D. Burden Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis Am J Hum Genet 89 2011 432 437
16. L. Naldi, and D. Gambini The clinical spectrum of psoriasis Clin Dermatol 25 2007 510 518
17. D. Magne, G. Palmer, J.L. Barton, F. Mezin, D. Talabot-Ayer, S. Bas, T. Duffy, M. Noger, P.A. Guerne, and M.J. Nicklin The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes Arthritis Res Ther 8 2006 R80
18. O. Ichii, S. Otsuka, N. Sasaki, A. Yabuki, H. Ohta, M. Takiguchi, Y. Hashimoto, D. Endoh, and Y. Kon Local overexpression of interleukin-1 family, member 6 relates to the development of tubulointerstitial lesions Lab Invest 90 2010 459 475
19. E.J. van Asseldonk, R. Stienstra, T.B. Koenen, L.J. van Tits, L.A. Joosten, C.J. Tack, and M.G. Netea The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation Obesity (Silver Spring) 18 2010 2234 2236
20. R.A. Ramadas, X. Li, D.M. Shubitowski, S. Samineni, M. Wills-Karp, and S.L. Ewart I.L-1 Receptor antagonist as a positional candidate gene in a murine model of allergic asthma Immunogenetics 58 2006 851 855
21. R.A. Ramadas, S.L. Ewart, B.D. Medoff, and A.M. LeVine Interleukin-1 family member 9 stimulates chemokine production and neutrophil influx in mouse lungs Am J Respir Cell Mol Biol 44 2011 134 145
22. J.B. Vos, M.A. van Sterkenburg, K.F. Rabe, J. Schalkwijk, P.S. Hiemstra, and N.A. Datson Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense Physiol Genomics 21 2005 324 336
23. Y.A. Bochkov, K.M. Hanson, S. Keles, R.A. Brockman-Schneider, N.N. Jarjour, and J.E. Gern Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma Mucosal Immunol 3 2010 69 80
24. R.T. Chustz, D.R. Nagarkar, J.A. Poposki, S. Favoreto Jr., P.C. Avila, R.P. Schleimer, and A. Kato Regulation and function of the IL-1 family cytokine IL-1F9 in human bronchial epithelial cells Am J Respir Cell Mol Biol 45 2011 145 153