Neuroprotective effects of triterpene glycosides from glycine max against glutamate induced toxicity in primary cultured rat cortical cells

International Journal of Molecular Sciences

Volumn 13, Issue 8, 2012, Pages 9642-9648

  Moon, Hyung In ^a   Lee, Jai Heon ^a  

^a Dong A University   (South Korea)

Author keywords

Glutamate induced toxicity; Glycine max; Neuroprotective; Triterpene glycosides

Indexed keywords

3 O [ALPHA RHAMNOPYRANOSYL(1-2) BETA GLUCOPYRANOSYL(1-2) BETA GLUCURONOPYRANOSYL]OLEAN 12 EN 3BETA,22BETA,24 TRIOL; 3 O [BETA GLUCOPYRANOSYL(1-2) BETA GALACTOPYRANOSYL(1-2) BETA GLUCURONOPYRANOSYL]OLEAN 12 EN 3BETA,22BETA,24 TRIOL; GLUTAMIC ACID; GLYCINE MAX EXTRACT; METHANOL; PLANT EXTRACT; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; 3-O-(GLUCOPYRANOSYL-(1-2)-GALACTOPYRANOSYL-(1-2)-GLUCURONOPYRANOSYL)OLEAN-12-EN-3,22,24-TRIOL; GLUTAMIC ACID DERIVATIVE; GLYCOSIDE; NEUROPROTECTIVE AGENT; SAPONIN; TRITERPENE;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FETUS; NEUROPROTECTION; NONHUMAN; RAT; SOYBEAN; ANIMAL; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; NERVE CELL; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; GLUTAMATES; GLYCOSIDES; NEURONS; NEUROPROTECTIVE AGENTS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; SOYBEANS; TRITERPENES;

EID: 84865011423     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13089642     Document Type: Article

References (11)

1. Aparicio-Fernández, X.; García-Gasca, T.; Yousef, G.G.; Lila, M.A.; González de Mejia, E.; Loarca-Pina, G. Chemopreventive activity of polyphenolics from black Jamapa bean (Phaseolus vulgaris L.) on HeLa and HaCaT cells. J. Agric. Food Chem. 2006, 54, 2116-2122.
2. Iriti, M.; di Maro, A.; Bernasconi, S.; Burlini, N.; Simonetti, P.; Picchi, V.; Panigada, C.; Gerosa, G.; Parente, A.; Faoro, F. Nutritional traits of bean (Phaseolus vulgaris) seeds from plants chronically exposed to ozone pollution. J. Agric. Food Chem. 2009, 57, 201-208.
3. Hangen, L.; Bennink, M.R. Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats. Nutr. Cancer 2002, 44, 60-65.
4. Duodu, K.G.; Nunes, A.; Delgadillo, I.; Parker, M.L.; Mills, E.N.C.; Belton, P.S. Effect of grain structure and cooking on sorghum and maize in vitro protein digestibility. J. Cereal Sci. 2002, 35, 161-174.
5. Wang, R.; Zhou, J.; Tang, X.C. Tacrine attenuates hydrogen peroxideinduced apoptosis by regulating expression of apoptosisrelated genes in rat PC12 cells. Mol. Brain Res. 2002, 107, 1-8.
6. Sucher, N.J.; Awobuluyi, M.; Choi, Y.B.; Lipton, S.A. NMDA receptors: From genes to channels. Trends Pharmacol. Sci. 1996, 17, 348-355.
7. Mizuno, T. The biphasic role of microglia in Alzheimer's disease. Int. J. Alzheimer's Dis. 2012, doi:10.1155/2012/737846.
8. Koo, K.A.; Kim, S.H.; Oh, T.H.; Kim, Y.C. Acteoside and its aglycones protect primary cultures of rat cortical cells from glutamate-induced excitotoxicity. Life Sci. 2006, 79, 709-716.
9. Trist, D.G. Excitatory aminoacid agonists and antagonists: Pharmacology and therapeutic applications. Pharm. Acta Helvetiae 2000, 74, 221-229.
10. Dong, M.; He, X.; Liu, R.H. Phytochemicals of black bean seed coats: Isolation, structure elucidation, and their antiproliferative and antioxidative activities. J. Agric. Food Chem. 2007, 55, 6044-6051.
11. Koo, K.A.; Lee, M.K.; Kim, S.H.; Jeong, E.J.; Kim, S.Y.; Oh, T.H.; Kim, Y.C. Pinusolide and 15-methoxypinusolidic acid attenuate the neurotoxic effect of staurosporine in primary cultures of rat cortical cells. Br. J. Pharmacol. 2007, 150, 65-71.