Effects of ozone therapy on haemostatic and oxidative stress index in coronary artery disease

European Journal of Pharmacology

Volumn 691, Issue 1-3, 2012, Pages 156-162

  Martínez Sánchez, Gregorio ^a   Delgado Roche, Livan ^b   Díaz Batista, Arquímides ^c   Pérez Davison, Gema ^d   Re, Lamberto ^a,d  

^a Medinat srl Clinic   (Italy)

^b UNIVERSITY OF HAVANA   (Cuba)

^c National Institute of Angiology and Vascular Surgery   (Cuba)

^d UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Aspirin; Coronary artery diseases; Oxidative stress; Ozone; Policosanol

Indexed keywords

ACETYLSALICYLIC ACID; CAPTOPRIL; CATALASE; HYDROGEN PEROXIDE; NIFEDIPINE; OXYGEN; OZONE; PENTAERYTHRITYL TETRANITRATE; POLICOSANOL; SUPEROXIDE DISMUTASE;

ABSENCE OF SIDE EFFECTS; ADULT; AERATION; AGED; ANTICOAGULANT THERAPY; ARTICLE; BIOCHEMISTRY; BLEEDING TIME; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DETOXIFICATION; DISEASE MARKER; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; HEMOSTASIS; HUMAN; HYPERTENSION; LIPID OXIDATION; MAJOR CLINICAL STUDY; MALE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; OZONE THERAPY; PARALLEL DESIGN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTHROMBIN TIME; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TREATMENT RESPONSE;

AGED; AGED, 80 AND OVER; ANTIOXIDANTS; ASPIRIN; BIOLOGICAL MARKERS; CORONARY ARTERY DISEASE; FATTY ALCOHOLS; FEMALE; HEMOSTASIS; HUMANS; MALE; MIDDLE AGED; OXIDATIVE STRESS; OZONE; REACTIVE OXYGEN SPECIES;

EID: 84865001031     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.07.010     Document Type: Article

References (59)

1. M.L. Arruzazabala, S. Valdes, R. Mas, D. Carbajal, and L. Fernandez Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers Pharmacol. Res. 36 1997 293 297 (Pubitemid 27507586)
2. M.T. Baltazar, R.J. Dinis-Oliveira, J.A. Duarte, M.L. Bastos, and F. Carvalho Antioxidant properties and associated mechanisms of salicylates Curr. Med. Chem. 18 2011 3252 3264
3. I.F. Benzie, and J.J. Strain The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay Anal. Biochem. 239 1996 70 76
4. B. Biedunkiewicz, S. Lizakowski, L. Tylicki, A. Skiboeska, T. Nieweglowski, A. Chamienia, A. Debska-Slizien, and B. Rutkowski Blood coagulation unaffected by ozonated autohemotherapy in patients on maintenance hemodialysis Arch. Med. Res. 37 2006 1034 1037 (Pubitemid 44512064)
5. V. Bocci, V. Travagli, and I. Zanardi May oxygen-ozone therapy improves cardiovascular disorders? Cardiovasc. Hematol. Disord. Drug Targets 9 2009 78 85
6. V.A. Bocci, I. Zanardi, and V. Travagli Ozone acting on human blood yields a hormetic dose-response relationship J. Transl. Med. 9 2011 66
7. J. Calunga, Y. Paz, S. Menéndez, A. Martínez, and A. Hernández Rectal ozone therapy for patients with pulmonary emphysema Rev. Med. Chile 139 2011 439 447
8. C.L. Campbell, S. Smyth, G. Montalescot, and S.R. Steinhubl Aspirin dose for the prevention of cardiovascular disease: a systematic review J. Am. Med. Assoc. 297 2007 2018 2024 (Pubitemid 46740354)
9. V. Cardile, X. Jiang, A. Russo, F. Casella, M. Renis, and M. Bindoni Effects of ozone on some biological activities of cells in vitro Cell Biol. Toxicol. 11 1995 11 21
10. G. Castano, R. Menendez, R. Mas, A. Amor, J.L. Fernandez, R.L. Gonzalez, M. Lezcay, and E. Alvarez Effects of policosanol and lovastatin on lipid profile and lipid peroxidation in patients with dyslipidemia associated with type 2 diabetes mellitus Int. J. Clin. Pharmacol. Res. 22 2002 89 99 (Pubitemid 36758536)
11. H. Chen, B. Xing, X. Liu, B. Zhan, J. Zhou, H. Zhu, and Z. Chen Ozone oxidative preconditioning inhibits inflammation and apoptosis in a rat model of renal ischemia/reperfusion injury Eur. J. Pharmacol. 581 2008 306 314
12. A.T Collaboration Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients Br. Med. J. 324 2002 71 86
13. R. Colombo, F. D'Angelo, A. Arzini, F. Abbritti, and L. Boccalon Arterial occlusive disease: pharmacological therapy and ozone therapy Gazz. Med. Ital. Arch. Sci. Med. 159 2000 53 57 (Pubitemid 30452116)
14. L. Delgado-Roche, G Martínez-Sánchez, A. Díaz-Batista, and L. Re Effects of ozone therapy on oxidative stress biomarkers in coronary artery disease patients Int. J. Ozone Res. 10 2011 99 104
15. 2 mix Int. J. Ozone Ther. 8 2009 217 221
16. H. Esterbauer, and K.H. Cheeseman Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal Methods Enzymol. 186 1990 407 421 (Pubitemid 20279982)
17. F. Faul, E. Erdfelder, A.G. Lang, and A. Buchner GPower 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences Behav. Res. Methods 39 2007 175 191
18. G. Flores-Mateo, P. Carrillo-Santisteve, R. Elosua, E. Guallar, J. Marrugat, J. Bleys, and M.I. Covas Antioxidant enzyme activity and coronary heart disease: meta-analyses of observational studies Am. J. Epidemiol. 170 2009 135 147
19. M. Franco, R.S. Cooper, U. Bilal, and V. Fuster Challenges and opportunities for cardiovascular disease prevention Am. J. Med. 124 2011 95 102
20. R. Giunta, A. Coppola, C. Luongo, A. Sammartino, S. Guastafierro, A. Grassia, L. Giunta, L. Mascolo, A. Tirelli, and L. Coppola Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease Ann. Hematol. 80 2001 745 748 (Pubitemid 34041432)
21. R. Gonzalez, A. Borrego, Z. Zamora, C. Romay, F. Hernandez, S. Menendez, T. Montero, and E. Rojas Reversion by ozone treatment of acute nephrotoxicity induced by cisplatin in rats Mediators Inflamm. 13 2004 307 312 (Pubitemid 40018363)
22. I. Graham, D. Atar, K. Borch-Johnsen, G. Boysen, G. Burell, R. Cifkova, J. Dallongeville, G. De Backer, S. Ebrahim, B. Gjelsvik, C. Herrmann-Lingen, A. Hoes, S. Humphries, M. Knapton, J. Perk, S.G. Priori, K. Pyorala, Z. Reiner, L. Ruilope, S. Sans-Menendez, W. Scholte op Reimer, P. Weissberg, D. Wood, J. Yarnell, J.L. Zamorano, E. Walma, T. Fitzgerald, M.T. Cooney, and A. Dudina European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by representatives of nine societies and by invited experts) Eur. Heart J. 28 2007 2375 2414 (Pubitemid 47542237)
23. D. Guanche, Z. Zamora, F. Hernandez, K. Mena, Y. Alonso, M. Roda, M. Gonzales, and R. Gonzales Effect of ozone/oxygen mixture on systemic oxidative stress and organic damage Toxicol. Mech. Methods 20 2010 25 30
24. R. Gupta, P. Joshi, V. Mohan, K.S. Reddy, and S. Yusuf Epidemiology and causation of coronary heart disease and stroke in India Heart 94 2008 16 26
25. J.L. Haining, and J.S. Legan Improved assay for catalase based upon steady-state substrate concentration Anal. Biochem. 45 1972 469 479
26. F.A. Hernandez Rosales, J.L. Calunga Fernandez, J. Turrent Figueras, S. Menendez Cepero, and A. Montenegro Perdomo Ozone therapy effects on biomarkers and lung function in asthma Arch. Med. Res. 36 2005 549 554 (Pubitemid 41140064)
27. D. Huang, B. Ou, and R.L. Prior The chemistry behind antioxidant capacity assays J. Agric. Food Chem. 53 2005 1841 1856 (Pubitemid 40403051)
28. H.A. Johnston-Cox, and K. Ravid Adenosine and blood platelets Purinergic Signal 7 2011 357 365
29. E. Kowalczyk, A. Kopff, J. Blaszczyk, P. Fijalkowski, and M. Kopff The influence of selected nonsteroidal anti-inflammatory drugs on antioxidative enzymes activity Pol. Arch. Med. Wewn. 115 2006 112 117 (Pubitemid 44047452)
30. O.S. Leon Fernandez, H.H. Ajamieh, J. Berlanga, S. Menendez, R. Viebahn-Hansler, L. Re, and A.M. Carmona Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion Transplant Int. 21 2008 39 48 (Pubitemid 350198290)
31. G. Martinez-Sanchez, S.M. Al-Dalain, S. Menendez, L. Re, A. Giuliani, E. Candelario-Jalil, H. Alvarez, J.I. Fernandez-Montequin, and O.S. Leon Therapeutic efficacy of ozone in patients with diabetic foot Eur. J. Pharmacol. 523 2005 151 161 (Pubitemid 41562387)
32. G. Martinez-Sanchez, A. Giuliani, G. Perez-Davison, and O.S. Leon-Fernandez Oxidized proteins and their contribution to redox homeostasis Redox Rep. 10 2005 175 185 (Pubitemid 44111134)
33. R.P. Mason Optimal therapeutic strategy for treating patients with hypertension and atherosclerosis: focus on olmesartan medoxomil Vasc. Health Risk Manage. 7 2011 405 416
34. J.D. Miller, Y. Chu, R.M. Brooks, W.E. Richenbacher, R. Pena-Silva, and D.D. Heistad Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans J. Am. Coll. Cardiol. 52 2008 843 850
35. M. Noa, R. Mas, and C. Lariot Protective effect of policosanol on endothelium and intimal thickness induced by forceps in rabbits J. Med. Food 10 2007 452 459 (Pubitemid 47493491)
36. G. Ozdemirler, G. Mehmetcik, S. Oztezcan, G. Toker, A. Sivas, and M. Uysal Peroxidation potential and antioxidant activity of serum in patients with diabetes mellitus and myocard infarction Horm. Metab. Res. 27 1995 194 196
37. V. Rao, and R. Kiran Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease J. Cardiovasc. Dis. Res. 2 2011 57 60
38. L. Re, M.N. Mawsouf, S. Menendez, O.S. Leon, G. Martínez- Sánchez, and F. Hernandez Ozone therapy: clinical and basic evidence of its therapeutic potential Arch. Med. Res. 39 2008 17 26 (Pubitemid 350192013)
39. Z.Z. Rodriguez, D. Guanche, R.G. Alvarez, F.H. Rosales, Y. Alonso, and S. Schulz Preconditioning with ozone/oxygen mixture induces reversion of some indicators of oxidative stress and prevents organic damage in rats with fecal peritonitis Inflamm. Res 2009
40. V.L. Roger, A.S. Go, D.M. Lloyd-Jones, R.J. Adams, J.D. Berry, T.M. Brown, M.R. Carnethon, S. Dai, G. de Simone, E.S. Ford, C.S. Fox, H.J. Fullerton, C. Gillespie, K.J. Greenlund, S.M. Hailpern, J.A. Heit, P.M. Ho, V.J. Howard, B.M. Kissela, S.J. Kittner, D.T. Lackland, J.H. Lichtman, L.D. Lisabeth, D.M. Makuc, G.M. Marcus, A. Marelli, D.B. Matchar, M.M. McDermott, J.B. Meigs, C.S. Moy, D. Mozaffarian, M.E. Mussolino, G. Nichol, N.P. Paynter, W.D. Rosamond, P.D. Sorlie, R.S. Stafford, T.N. Turan, M.B. Turner, N.D. Wong, and J. Wylie-Rosett Heart disease and stroke statistics - 2011 update: a report from the American Heart Association Circulation 123 2011 e18 e209
41. A. Romero Valdes, R. Blanco Gonzalez, S. Menendez Cepero, M. Gomez Moraleda, and J. Ley Pozo Arteriosclerosis obliterans and ozone therapy. Its administration by different routes Angiologia 45 1993 177 179
42. A.H. Schmaier 5 ed. 2008 Churchill Livingstone Elsevier Philadelphia
43. Schwartz, A., Martinez-Sanchez, G., Re, L., 2011. Guia para el uso médico del ozono. Fundamentos terapéuticos e indicaciones, Madrid.
44. J. Scott The pathogenesis of atherosclerosis and new opportunities for treatment and prevention J. Neural Transm. Suppl. 63 2002 1 17 (Pubitemid 38471306)
45. A. Seda Artis, S. Aydogan, and M. Gokhan Sahin The effects of colorectally insufflated oxygen-ozone on red blood cell rheology in rabbits Clin. Hemorheol. Microcirc. 45 2010 329 336
46. J. Sedlak, and R.H. Lindsay Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Anal. Biochem. 25 1968 192 205
47. T.H. Stadlbauer, A. Eisele, M.C. Heidt, H.H. Tillmanns, and S. Schulz Preconditioning with ozone abrogates acute rejection and prolongs cardiac allograft survival in rats Transplant Proc. 40 2008 974 977 (Pubitemid 351794291)
48. J. Steppan, T. Meaders, M. Muto, and K.J. Murphy A metaanalysis of the effectiveness and safety of ozone treatments for herniated lumbar discs J. Vasc. Interv. Radiol. 21 2010 534 548
49. B. Turczynski, J. Sroczynski, Z. Antoszewski, B. Matyszczyk, G. Krupa, J. Mlynarski, and M. Strugala Ozone therapy and viscosity of blood and plasma, distance of intermittent claudication and certain biochemical components in patients with diabetes type II and ischemia of the lower extremities Pol. Tyg. Lek. 46 1991 708 710
50. K. Uno, and S.J. Nicholls Biomarkers of inflammation and oxidative stress in atherosclerosis Biomark Med. 4 2010 361 373
51. G. Verrazzo, L. Coppola, C. Luongo, A. Sammartino, R. Giunta, A. Grassia, R. Ragone, and A. Tirelli Hyperbaric oxygen, oxygen-ozone therapy, and rheologic parameters of blood in patients with peripheral occlusive arterial disease Undersea Hyperb. Med. 22 1995 17 22
52. WHO, 2008. Department of Measurement & Health Information Systems of the Information, Evidence and Research Cluster. In: Press, W. (Ed.), Department of Measurement & Health Information Systems of the Information, Evidence and Research Cluster. World Health Organization, Geneva, pp. 29-31.
53. V. Witko-Sarsat, M. Friedlander, T. Nguyen Khoa, C. Capeillere-Blandin, A.T. Nguyen, S. Canteloup, J.M. Dayer, P. Jungers, T. Drueke, and B. Descamps-Latscha Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure J. Immunol. 161 1998 2524 2532 (Pubitemid 28397070)
54. V. Witko-Sarsat, T. Nguyen-Khoa, P. Jungers, T.B. Drueke, and B. Descamps-Latscha Advanced oxidation protein products as a novel molecular basis of oxidative stress in uraemia Nephrol. Dial. Transplant. 14 1 1999 76 78 (Pubitemid 29041848)
55. WMA, 2004. World Medical Association Declaration of Helsinki. Ethical Principles for Medical Research Involving Human Subjects. J. Int. Bioethique, Adopted by the 18th WMA General Assembly, Helsinki, Finland, June 1964, pp. 124-129.
56. H. Yang, L.J. Roberts, M.J. Shi, L.C. Zhou, B.R. Ballard, A. Richardson, and Z.M. Guo Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E Circ. Res. 95 2004 1075 1081 (Pubitemid 39557894)
57. S. Yusuf, S. Hawken, S. Ounpuu, T. Dans, A. Avezum, F. Lanas, M. McQueen, A. Budaj, P. Pais, J. Varigos, and L. Lisheng Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study Lancet 364 2004 937 952 (Pubitemid 39208455)
58. S. Zaky, E. Fouad, and H.K. HI The effect of rectal ozone on the portal vein oxygenation and pharmacokinetics of propranolol in liver cirrhosis (a preliminary human study) Br. J. Clin. Pharmacol. 71 2011 411 415
59. S. Zaky, S.E. Kamel, M.S. Hassan, N.A. Sallam, M.A. Shahata, S.R. Helal, and H. Mahmoud Preliminary results of ozone therapy as a possible treatment for patients with chronic hepatitis C J. Altern. Complement. Med. 17 2011 259 263