A Metaanalysis of the Effectiveness and Safety of Ozone Treatments for Herniated Lumbar Discs

Journal of Vascular and Interventional Radiology

Volumn 21, Issue 4, 2010, Pages 534-548

  Steppan, Jim ^a   Meaders, Thomas ^a   Muto, Mario ^d   Murphy, Kieran J ^b,c  

^a ActiveO   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CARDARELLI HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; CORTICOSTEROID;

ADULT; AGED; ARTICLE; COMPLICATION; CONTROLLED STUDY; FEMALE; HUMAN; LUMBAR DISK HERNIA; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; OZONE THERAPY; PAIN ASSESSMENT; PATIENT SAFETY; PRIORITY JOURNAL; RATING SCALE; RETROSPECTIVE STUDY; SYSTEMATIC ERROR; TREATMENT OUTCOME; VISUAL ANALOG SCALE;

COMORBIDITY; HUMANS; INTERVERTEBRAL DISK DISPLACEMENT; LOW BACK PAIN; OZONE; PREVALENCE; QUALITY OF LIFE; RISK ASSESSMENT; RISK FACTORS;

EID: 77949653469     PISSN: 10510443     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvir.2009.12.393     Document Type: Article

References (38)

1. Mixter W.J., and Barr J.S. Rupture of the intervertebral disc with involvement of the spinal canal. N Engl J Med 211 (1934) 210-215
2. Butterman G. Treatment of lumbar disc herniation: epidural steroid injection compared with discectomy. J Bone Joint Surg Am 86 (2004) 670-679
3. Choy D.S.J. Percutaneous laser disc decompression: a 17-year experience. Photomed Laser Surg 22 (2004) 407-410
4. Alexandre A., Corò L., Azuelos A., and Pellone M. Percutaneous nucleoplasty for discoradicular conflict. Acta Neurochir Suppl 92 (2005) 83-86
5. Pauza K., Howell S., Dreyfuss P., Peloza J., Dawson K., and Bogduk N. A randomized, placebo-controlled trial of intradiscal electrothermal therapy for the treatment of discogenic low back pain. Spine J 4 (2004) 27-35
6. Barendse G.A., van Den Berg S.G., Kessels A.H., Weber W.E., and van Kleef M. Randomized controlled trial of percutaneous intradiscal radiofrequency thermocoagulation for chronic discogenic back pain: lack of effect from a 90-second 70 C lesion. Spine 26 (2001) 287-292
7. Andreula C., Muto M., and Leonardi M. Interventional spinal procedures. Eur J Radiol 50 (2004) 112-119
8. Muto M., and Avella F. Percutaneous treatment of herniated lumbar disc by intradiscal oxygen-ozone injection. Intervent Neuroradiol 4 (1998) 279-286
9. Verga C. Nuovo approccio terapeutico alle ernie e protusioni discali lombari. Riv Neuroradiol 2 (1989) 148
10. Simonetti L., Raffi L., Cenni P., Agati R., and Leonardi M. Pharmacological mechanisms underlying oxygen-ozone therapy for herniated disc. Riv Ital Ossigeno-Ozonoterapia 2 (2003) 7-11
11. Maximum acceptable level of ozone, 21 C.F.R. Sect. 801.415 (2008).
12. Pellicanò G., Martinelli F., Tavanti V., et al. The Italian oxygen-ozone therapy federation (FIO) study on oxygen-ozone treatment of herniated disc. Int J Ozone Ther 6 (2007) 7-15
13. LeClaire R., Blier F., Fortin L., et al. A cross-sectional study comparing the Oswestry and Roland-Morris functional disability scales in two populations of patients with low back pain of different levels of severity. Spine 22 (1997) 68-71
14. Sutton A., Abrams K., Jones D., Sheldon T., and Song F. Defining outcome measures used for combining via meta-analysis. In: Cressie N., Fisher N., Johnstone I., et al. (Eds). Methods for meta-analysis in medical research (2000), John Wiley and Sons, West Sussex, UK 20-31
15. Lipsey M., and Wilson D. Selecting, computing, and coding the effect size statistic. In: Laughton C.D., Carr E., and Robinson S. (Eds). Practical meta-analysis, applied social research methods series vol. 49 (2001), SAGE, Thousand Oaks, CA 39-40
16. Atkins D., Briss P., Eccles M., et al. Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system. BMC Health Serv Res 5 (2005) 25
17. Sutton A., Abrams K., Jones D., Sheldon T., and Song F. Random effects methods for combining study estimates. In: Cressie N., Fisher N., Johnstone I., et al. (Eds). Methods for meta-analysis in medical research (2000), John Wiley and Sons, West Sussex, UK 73-86
18. Tian L., Tianxi C., Pfeffer, et al. Exact and efficient inference procedure for meta-analysis and its application to the analysis of independent 2 x 2 tables with all available data but without artificial continuity correction. Biostatistics 10 (2009) 275-281
19. Sutton A., Abrams K., Jones D., Sheldon T., and Song F. Publication bias. In: Cressie N., Fisher N., Johnstone I., et al. (Eds). Methods for meta-analysis in medical research (2000), John Wiley and Sons, West Sussex, UK 117-119
20. Eggar M., Smith G., Schneider M., and Minder C. Bias in meta-analysis detected by a simple graphical test. Br Med J 315 (1997) 629-634
21. Muto M., Ambrosanio G., Guarnieri G., et al. Low back pain and sciatica: treatment with intradiscal-intraforaminal O2-O3 injection: our experience. Radiol Med (Torino) 113 (2008) 695-706
22. Gallucci M., Limbucci N., Zugaro L., et al. Sciatica: treatment with intradiscal and intraforaminal injections of steroid and oxygen-ozone versus steroid only. Radiology 242 (2007) 907-913
23. Oder B., Loewe M., Reisegger M., Lang W., Ilias W., and Thurnher S.A. CT-guided ozone/steroid therapy for the treatment of degenerative spinal disease-effect of age, gender, disc pathology and multi-segmental changes. Neuroradiology 50 (2008) 777-785
24. Buric J., Alexandre A., Coro L., and Azuelos A. Intradiscal ozone treatment of non-contained disc herniations 18 month follow-up. Riv Ital Ossigeno-Ozonoterapia 2 (2003) 153-160
25. Hagg O., Fritzell P., and Nordwall A. The clinical importance of changes in outcome scores after treatment for chronic low back pain. Eur Spine J 12 (2003) 12-20
26. Fritz J., and Irrgang J. A comparison of the modified Oswestry low back pain disability questionnaire and the Quebec back pain disability scale. Phys Ther 81 (2001) 776-788
27. Buric J. Ozone chemonucleolysis vs microdiscectomy prospective controlled study with 18 months follow-up. Riv Ital Ossigeno-Ozonoterapia 4 (2005) 49-54
28. Leonardi M., Albini L., Riccioli S., et al. Oxygen-Ozone chemonucleolysis for herniated disc with sciatica: a comparison of treatments in patients with subacute and chronic symptoms. Riv Ital Ossigeno-Ozonoterapia 5 (2006) 33-36
29. Qing H., Feng D., Tao L., Hui L., Fang L.X., and Dong L. Report on 602 cases of percutaneous ozone puncture chemonucleolysis treating lumbar disc protrusion. Riv Ital Ossigeno-Ozonoterapia 4 (2005) 145-148
30. Ying W., Jiang C.M., and Wang Z.M. Percutaneous treatment of lumbar disc herniation by oxygen-ozone injection a clinical study of 322 cases. Riv Ital Ossigeno-Ozonoterapia 4 (2005) 6-8
31. Muto M., Andreula C., and Leonardi M. Treatment of herniated lumbar disc by intradiscal and intraforaminal oxygen-ozone (O2-O3) injection. J Neuroradiol 31 (2004) 183-189
32. Andreula C., Simonetti L., Santis F., Agati R., Ricci R., and Leonardi M. Minimally invasive oxygen-ozone therapy for lumbar disk herniation. AJNR Am J Neuroradiol 24 (2003) 996-1000
33. He X.F., Yu Z.J., Li Y.H., et al. Percutaneous injection of intradiscal and paraspinal space with O2-O3 mixture to treat lumbar disc herniation. Riv Ital Ossigeno-Ozonoterapia 2 (2003) 135-138
34. Center for Medicare and Medicaid Services (CMS). Decision memo for thermal intradiscal procedures (CAG-00387N) (2008), CMS, Woodlawn, MD 1-31
35. Mirzai H., Tekin I., Yaman O., and Bursali A. The results of nucleoplasty in patients with lumbar herniated disc: a prospective clinical study of 52 consecutive patients. Spine J 7 (2007) 88-93
36. Sutton A., Abrams K., Jones D., Sheldon T., and Song F. Study quality. In: Cressie N., Fisher N., Johnstone I., et al. (Eds). Methods for meta-analysis in medical research (2000), John Wiley and Sons, West Sussex, UK 141
37. Johnson B.A. Therapeutic periradicular injections: It's a gas!. AJNR Am J Neuroradiol 26 (2005) 988-989
38. Barker F., and Carter B. Synthesizing medical evidence: systematic reviews and metaanalyses. Neurosurg Focus 19 (2005) 1-21