Small molecules that regulate zymosan phagocytosis of macrophage through deactivation of Rho GTPases

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 17, 2012, Pages 5262-5268

  Bang, Joon Seok ^a   Kim, Young Jin ^a   Song, Jiho ^a   Yoo, Jong Sun ^a   Lee, Seul ^a   Lee, Mi Ji ^a   Min, Hyeyoung ^a   Hwang, Kwang Woo ^a   Min, Kyung Hoon ^a  

^a Chung Ang University   (South Korea)

Author keywords

Macrophage; Phagocytosis; Rho GTPase; Small molecule; Zymosan

Indexed keywords

1 BROMO 4 PROPOXYBENZENE; 4' METHOXYBIPHENYL 3 CARBONITRILE; 4' METHOXYBIPHENYL 3 CARBONYL CHLORIDE; 4' METHOXYBIPHENYL 3 CARBOXYLIC ACID; 4' PROPOXY N [4 (PYRROLIDIN 1 YL)PROPYL]BIPHENYL 3 CARBOXAMIDE; 4' PROPOXY N PROPYLBIPHENYL 3 CARBOXAMIDE; 4' PROPOXYBIPHENYL 3 CARBONITRILE; 4' PROPOXYBIPHENYL 3 CARBONYL CHLORIDE; 4' PROPOXYBIPHENYL 3 CARBOXYLIC ACID; BIPHENYL CARBOXAMIDE DERIVATIVE; BIPHENYL DERIVATIVE; N (3 MORPHOLINPROPYL) 4' PROPOXYBIPHENYL 3 CARBOXAMIDE; N [2 (DIETHYLAMINO)ETHYL] 4' PROPOXYBIPHENYL 3 CARBOXAMIDE; N [3 (4 METHYLPIPERAZIN 1 YL)PROPYL] 4' PROPOXYBIPHENYL 3 CARBOXAMIDE; N [3 (DIETHYLAMINO)PROPYL] 4' METHOXYBIPHENYL 3 CARBOXAMIDE; N [3 (DIETHYLAMINO)PROPYL] 4' PROPOXYBIPHENYL 3 CARBOXAMIDE; N [3 (DIMETHYLAMINO)PROPYL] 4' PROPOXYBIPHENYL 3 CARBOXAMIDE; N [3 (PIPERADIN 1 YL)PROPYL] 4' PROPOXYBIPHENYL 3 CARBOXAMIDE; PROTEIN CDC42; PROTEIN KINASE B; RAC1 PROTEIN; RAC2 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME INACTIVATION; HYDROLYSIS; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; PHAGOCYTOSIS; RHO GTP-BINDING PROTEINS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; ZYMOSAN;

EID: 84864991112     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.06.043     Document Type: Article

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