Expression of nestin in the podocytes of normal and diseased human kidneys

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 292, Issue 5, 2007, Pages

  Su, Wei ^a   Chen, Jing ^a   Yang, Haichun ^a   You, Li ^a   Xu, Lan ^a   Wang, Xiang ^a   Li, Ruixi ^a   Gao, Lu ^a   Gu, Yong ^a   Lin, Shanyan ^a   Xu, Hong ^a   Breyer, Matthew D ^b   Hao, Chuan Ming ^a,b,c  

^a FUDAN UNIVERSITY   (China)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cytoskeletal protein; IgA nephropathy; Proteinuria

Indexed keywords

BENAZEPRIL; IMMUNOGLOBULIN A; LOSARTAN; MESSENGER RNA; NESTIN; PREDNISONE; VIMENTIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GLOMERULOSCLEROSIS; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KIDNEY; KIDNEY BIOPSY; MEMBRANOUS GLOMERULONEPHRITIS; NEPHRECTOMY; PODOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEINURIA; REAL TIME POLYMERASE CHAIN REACTION; TREATMENT RESPONSE;

ADOLESCENT; ADULT; AGED; GENE EXPRESSION REGULATION; HUMANS; INTERMEDIATE FILAMENT PROTEINS; KIDNEY DISEASES; MIDDLE AGED; NERVE TISSUE PROTEINS; PODOCYTES;

EID: 34248229649     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00319.2006     Document Type: Article

References (24)

1. Chen J, Boyle S, Zhao M, Su W, Takahashi K, Davis LS, de Caestecker MP, Takahashi T, Breyer MD, Hao CM. Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes. J Am Soc Nephrol 17: 1283-1291, 2006.
2. Delacour A, Nepote V, Trumpp A, Herrera P. Nestin expression in pancreatic exocrine cell lineages. Mech Dev 121: 3-14, 2004.
3. Herrmann H, Aebi U. Intermediate filaments and their associates: multi-talented structural elements specifying cytoarchitecture and cytodynamics. Curr Opin Cell Biol 12: 79-90, 2000.
4. Holzman LB, St John PL, Kovari IA, Verma R, Holthofer H, Abrahamson DR. Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int 56: 1481-1491, 1999.
5. Ipe D. Performing the Friedman test and the associated multiple comparison test using PROC GLM. Proceedings of the Twelfth Annual SAS Users Group International Conference, Cary, NC: SAS Institute, 12: 1146-1148, 1987.
6. Kachinsky AM, Dominov JA, Miller JB. Myogenesis and the intermediate filament protein, nestin. Dev Biol 165: 216-228, 1994.
7. Kim YH, Goyal M, Kurnit D, Wharram B, Wiggins J, Holzman L, Kershaw D, Wiggins R. Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat. Kidney Int 60: 957-968, 2001.
8. Klein T, Ling Z, Heimberg H, Madsen O, Heller R, Serup P. Nestin is expressed in vascular endothelial cells in the adult human. J Histochem Cytochem 51: 697-706, 2003.
9. Kobayashi N, Reiser J, Schwarz K, Sakai T, Kriz W, Mundel P. Process formation of podocytes: morphogenetic activity of microtubules and regulation by protein serine/threonine phosphatase PP2A. Histochem Cell Biol 115: 255-266, 2001.
10. Kriz W, Hackenthal E, Nobiling R, Sakai T, Elger M, Hahnel B. A role for podocytes to counteract capillary wall distension. Kidney Int 45: 369-376, 1994.
11. Lendahl U, Zimmerman LB, McKay RD. CNS stem cells express a new class of intermediate filament protein. Cell 60: 585-595, 1990.
12. Li L, Mignone J, Yang M, Matic M, Penman S, Enikolopov G, Hoffman R. Nestin expression in hair follicle sheath progenitor cells. Proc Natl Acad Sci USA 100: 9958-9961, 2003.
13. Marvin MJ, Dahlstrand J, Lendahl U, McKay RD. A rod end deletion in the intermediate filament protein nestin alters its subcellular localization in neuroepithelial cells of transgenic mice. J Cell Sci 111: 1951-1961, 1998.
14. Mayer E, Hughes E, Carter D, Dick A. Nestin positive cells in adult human retina and in epiretinal membranes. Br J Ophthalmol 87: 1154-1158, 2003.
15. Michalczyk K, Ziman M. Nestin structure and predicted function in cellular cytoskeletal organisation. Histol Histopathol 20: 665-671, 2005.
16. Mundel P, Shankland SJ. Podocyte biology and response to injury. J Am Soc Nephrol 13: 3005-3015, 2002.
17. Neal CR, Crook H, Bell E, Harper SJ, Bates DO. Three-dimensional reconstruction of glomeruli by electron microscopy reveals a distinct restrictive urinary subpodocyte space. J Am Soc Nephrol 16: 1223-1235, 2005.
18. Ostalska-Nowicka D, Zachwieja J, Nowicki M, Witt M. Expression of intermediate filaments of podocytes within nephrotic syndrome glomerulopathies in children. Histochem Cell Biol 121: 109-113, 2004.
19. Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 83: 253-307, 2003.
20. Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature 427: 78-83, 2004.
21. Sjoberg G, Jiang WQ, Ringertz NR, Lendahl U, Sejersen T. Colocalization of nestin and vimentin/desmin in skeletal muscle cells demonstrated by three-dimensional fluorescence digital imaging microscopy. Exp Cell Res 214: 447-458, 1994.
22. Stamenkovic I, Skalli O, Gabbiani G. Distribution of intermediate filament proteins in normal and diseased human glomeruli. Am J Pathol 125: 465-475, 1986.
23. Wagner N, Wagner KD, Scholz H, Kirschner KM, Schedl A. Intermediate filament protein nestin is expressed in the developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1. Am J Physiol Regul Integr Comp Physiol 291: R779-R787, 2006.
24. Zou J, Yaoita E, Watanabe Y, Yoshida Y, Nameta M, Li H, Qu Z, Yamamoto T. Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury. Virchows Arch 448: 485-492, 2006.