Synthesis and pharmacological evaluation of [(4-Arylpiperazin-1-yl)-alkyl]- carbamic acid ethyl ester derivatives as potential anxiolytic agents

Archives of Pharmacal Research

Volumn 35, Issue 7, 2012, Pages 1143-1152

  Khatri, Manisha ^a   Rai, Santosh K ^b   Ranbhor, Ranjit ^c   Kishore, Krishna ^d   Tiwari, Manisha ^a  

^a UNIVERSITY OF DELHI   (India)

^b IMT Manesar   (India)

^c Glenmark Pharmaceuticals Limited   (India)

^d DEFENCE INSTITUTE OF PHYSIOLOGY AND ALLIED SCIENCES   (India)

Author keywords

Anxiolytic activity; Elevated plus Maze; Ligand binding; Molecular modeling; Serotonin receptor ligands

Indexed keywords

[2 (4 PHENYLPIPERAZIN 1 YL)ETHYL]CARBAMIC ACID ETHYL ESTER; [2 [4 (2 METHOXYPHENYL)PIPERAZINE 1 YL]ETHYL]CARBAMIC ACID ETHYL ESTER; [3 (4 PHENYLPIPERAZIN 1 YL)PROPYL]CARBAMIC ACID ETHYL ESTER; [3 [4 (2 METHOXYPHENYL)PIPERAZINE 1 YL]PROPYL]CARBAMIC ACID ETHYL ESTER; [4 (4 PHENYLPIPERAZIN 1 YL)BUTYL]CARBAMIC ACID ETHYL ESTER; [4 [4 (2 METHOXYPHENYL)PIPERAZINE 1 YL]BUTYL]CARBAMIC ACID ETHYL ESTER; AMINE; ANXIOLYTIC AGENT; ASPARTIC ACID; BUSPIRONE; DIAZEPAM; FUNCTIONAL GROUP; PHENYLALANINE; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG; URETHAN DERIVATIVE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BLOOD CHEMISTRY; CARBAMOYLATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HEMATOLOGICAL PARAMETERS; HYDROGEN BOND; LIGAND BINDING; MALE; MAZE TEST; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PROTON TRANSPORT; RADIOASSAY; RAT; STRUCTURE ANALYSIS; TOXICITY TESTING; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BEHAVIOR, ANIMAL; CARBAMATES; CEREBRAL CORTEX; COMPUTER-AIDED DESIGN; DISEASE MODELS, ANIMAL; ESTERS; HYDROGEN BONDING; LIGANDS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOTOR ACTIVITY; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN 5-HT1 RECEPTOR AGONISTS;

EID: 84864958953     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0704-8     Document Type: Article

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