Intra-parenchymal ferrous iron infusion causes neuronal atrophy, cell death and progressive tissue loss: Implications for intracerebral hemorrhage

Experimental Neurology

Volumn 237, Issue 2, 2012, Pages 363-369

  Caliaperumal, Jayalakshmi ^a   Ma, Yonglie ^a   Colbourne, Frederick ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Intracerebral hemorrhage; Iron; Neurodegeneration; Striatum; Stroke

Indexed keywords

FERROUS ION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN ATROPHY; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN NERVE CELL; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DENDRITE; HISTOLOGY; IRON OVERLOAD; MACROPHAGE; MALE; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ATROPHY; BRAIN EDEMA; CEREBRAL HEMORRHAGE; DISEASE MODELS, ANIMAL; IRON COMPOUNDS; MALE; NERVE DEGENERATION; NEURONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84864948341     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.07.001     Document Type: Article

References (43)

1. Auriat A.M., Wowk S., Colbourne F. Rehabilitation after intracerebral hemorrhage in rats improves recovery with enhanced dendritic complexity but no effect on cell proliferation. Behav. Brain Res. 2010, 214:42-47.
2. Auriat A.M., Silasi G., Wei Z., Paquette R., Paterson P., Nichol H., Colbourne F. Ferric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome. Exp. Neurol. 2012, 234:136-143.
3. Brown C.E., Boyd J.D., Murphy T.H. Longitudinal in vivo imaging reveals balanced and branch-specific remodeling of mature cortical pyramidal dendritic arbors after stroke. J. Cereb. Blood Flow Metab. 2010, 30:783-791.
4. Del Bigio M.R., Yan H.J., Buist R., Peeling J. Experimental intracerebral hemorrhage in rats. Magnetic resonance imaging and histopathological correlates. Stroke 1996, 27:2312-2319.
5. Felberg R.A., Grotta J.C., Shirzadi A.L., Strong R., Narayana P., Hill-Felberg S.J., Aronowski J. Cell death in experimental hemorrhage: the "black hole" model of hemorrhagic damage. Ann. Neurol. 2002, 51:517-524.
6. Frantzias J., Sena E.S., Macleod M.R., Al-Shahi Salman R. Treatment of intracerebral hemorrhage in animal models: meta-analysis. Ann. Neurol. 2011, 69:389-399.
7. Gibb R., Kolb B. A method for vibratome sectioning of Golgi-Cox stained whole rat brain. J. Neurosci. Methods 1998, 79:1-4.
8. Gonzalez C.L., Kolb B. A comparison of different models of stroke on behaviour and brain morphology. Eur. J. Neurosci. 2003, 18:1950-1962.
9. Gu Y., Hua Y., Keep R.F., Morgenstern L.B., Xi G. Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets. Stroke 2009, 40:2241-2243.
10. Hua Y., Schallert T., Keep R.F., Wu J., Hoff J.T., Xi G. Behavioral tests after intracerebral hemorrhage in the rat. Stroke 2002, 33:2478-2484.
11. Hua Y., Nakamura T., Keep R.F., Wu J., Schallert T., Hoff J.T., Xi G. Long-term effects of experimental intracerebral hemorrhage: the role of iron. J. Neurosurg. 2006, 104:305-312.
12. Huang F.P., Xi G., Keep R.F., Hua Y., Nemoianu A., Hoff J.T. Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J. Neurosurg. 2002, 96:287-293.
13. Kell D.B. Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. Arch. Toxicol. 2010, 84:825-889.
14. Kleim J.A., Jones T.A. Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage. J. Speech Lang. Hear Res. 2008, 51:S225-S239.
15. Kolb B., Forgie M., Gibb R., Gorny G., Rowntree S. Age, experience and the changing brain. Neurosci. Biobehav. Rev. 1998, 22:143-159.
16. MacLellan C.L., Auriat A.M., McGie S.C., Yan R.H., Huynh H.D., De Butte M.F., Colbourne F. Gauging recovery after hemorrhagic stroke in rats: implications for cytoprotection studies. J. Cereb. Blood Flow Metab. 2006, 26:1031-1042.
17. MacLellan C.L., Silasi G., Poon C.C., Edmundson C.L., Buist R., Peeling J., Colbourne F. Intracerebral hemorrhage models in rat: comparing collagenase to blood infusion. J. Cereb. Blood Flow Metab. 2008, 28:516-525.
18. MacLellan C.L., Plummer N., Silasi G., Auriat A.M., Colbourne F. Rehabilitation promotes recovery after whole blood-induced intracerebral hemorrhage in rats. Neurorehabil. Neural Repair 2011, 25:477-483.
19. MacLellan C.L., Paquette R., Colbourne F. A critical appraisal of experimental intracerebral hemorrhage research. J. Cereb. Blood Flow Metab. 2012, 32:612-617.
20. Murphy T.H., Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat. Rev. Neurosci. 2009, 10:861-872.
21. Nakamura T., Keep R.F., Hua Y., Hoff J.T., Xi G. Oxidative DNA injury after experimental intracerebral hemorrhage. Brain Res. 2005, 1039:30-36.
22. Nakamura T., Keep R.F., Hua Y., Nagao S., Hoff J.T., Xi G. Iron-induced oxidative brain injury after experimental intracerebral hemorrhage. Acta Neurochir. Suppl. 2006, 96:194-198.
23. Nakamura T., Kuroda Y., Yamashita S., Zhang X., Miyamoto O., Tamiya T., Nagao S., Xi G., Keep R.F., Itano T. Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage. Stroke 2008, 39:463-469.
24. Nguyen A.P., Huynh H.D., Sjovold S.B., Colbourne F. Progressive brain damage and alterations in dendritic arborization after collagenase-induced intracerebral hemorrhage in rats. Curr. Neurovasc. Res. 2008, 5:171-177.
25. Peeling J., Del Bigio M.R., Corbett D., Green A.R., Jackson D.M. Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke. Neuropharmacology 2001, 40:433-439.
26. Reid S.A., Sypert G.W., Boggs W.M., Willmore L.J. Histopathology of the ferric-induced chronic epileptic focus in cat: a Golgi study. Exp. Neurol. 1979, 66:205-219.
27. Sacco S., Marini C., Toni D., Olivieri L., Carolei A. Incidence and 10-year survival of intracerebral hemorrhage in a population-based registry. Stroke 2009, 40:394-399.
28. Schmued L.C., Hopkins K.J. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 2000, 874:123-130.
29. Selim M., Yeatts S., Goldstein J.N., Gomes J., Greenberg S., Morgenstern L.B., Schlaug G., Torbey M., Waldman B., Xi G., Palesch Y. Safety and tolerability of deferoxamine mesylate in patients with acute intracerebral hemorrhage. Stroke 2011, 42:3067-3074.
30. Song S., Hua Y., Keep R.F., He Y., Wang J., Wu J., Xi G. Deferoxamine reduces brain swelling in a rat model of hippocampal intracerebral hemorrhage. Acta Neurochir. Suppl. 2008, 105:13-18.
31. Takamatsu Y., Ishida A., Hamakawa M., Tamakoshi K., Jung C.G., Ishida K. Treadmill running improves motor function and alters dendritic morphology in the striatum after collagenase-induced intracerebral hemorrhage in rats. Brain Res. 2010, 1355:165-173.
32. 2+ injection. J. Neurochem. 1984, 42:976-980.
33. Wan S., Hua Y., Keep R.F., Hoff J.T., Xi G. Deferoxamine reduces CSF free iron levels following intracerebral hemorrhage. Acta Neurochir. Suppl. 2006, 96:199-202.
34. Wang J. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog. Neurobiol. 2010, 92:463-477.
35. Warkentin L.M., Auriat A.M., Wowk S., Colbourne F. Failure of deferoxamine, an iron chelator, to improve outcome after collagenase-induced intracerebral hemorrhage in rats. Brain Res. 2010, 1309:95-103.
36. Wasserman J.K., Schlichter L.C. Neuron death and inflammation in a rat model of intracerebral hemorrhage: effects of delayed minocycline treatment. Brain Res. 2007, 1136:208-218.
37. Willmore L.J., Ballinger W.E., Boggs W., Sypert G.W., Rubin J.J. Dendritic alterations in rat isocortex within an iron-induced chronic epileptic focus. Neurosurgery 1980, 7:142-146.
38. Willmore L.J., Rubin J.J. Formation of malonaldehyde and focal brain edema induced by subpial injection of FeCl2 into rat isocortex. Brain Res. 1982, 246:113-119.
39. Wu G., Xi G., Hua Y., Sagher O. T2* magnetic resonance imaging sequences reflect brain tissue iron deposition following intracerebral hemorrhage. Transl. Stroke Res. 2010, 1:31-34.
40. Wu H., Wu T., Xu X., Wang J. Iron toxicity in mice with collagenase-induced intracerebral hemorrhage. J. Cereb. Blood Flow Metab. 2011, 31:1243-1250.
41. Wu H., Wu T., Li M., Wang J. Efficacy of the lipid-soluble iron chelator 2,2'-dipyridyl against hemorrhagic brain injury. Neurobiol. Dis. 2012, 45:388-394.
42. Wu J., Hua Y., Keep R.F., Nakamura T., Hoff J.T., Xi G. Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 2003, 34:2964-2969.
43. Xi G., Keep R.F., Hoff J.T. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 2006, 5:53-63.