Strategic use of plasma and microsome binding to exploit in vitro clearance in early drug discovery

ACS Medicinal Chemistry Letters

Volumn 1, Issue 2, 2010, Pages 50-53

  Chang, George ^a   Steyn, Stefanus J ^a   Umland, John P ^a   Scott, Dennis O ^a  

^a PFIZER INC   (United States)

Author keywords

ADME parameters; clearance; dose; fraction unbound; microsome binding; Plasma binding

Indexed keywords

ARTICLE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; HUMAN; LIVER BLOOD FLOW; LIVER MICROSOME; MICROSOME; PLASMA; PRIORITY JOURNAL;

EID: 77956627250     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml900012h     Document Type: Article

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