Testosterone replacement therapy improves erythrocyte membrane lipid composition in hypogonadal men

Aging Male

Volumn 15, Issue 3, 2012, Pages 173-179

  Angelova, Petya ^a   Momchilova, Albena ^b   Petkova, Diana ^b   Staneva, Galya ^b   Pankov, Roumen ^c   Kamenov, Zdravko ^a  

^a UNIVERSITY HOSPITAL ALEXANDROVSKA   (Bulgaria)

^b INSTITUTE OF BIOPHYSICS AND BIOMEDICAL ENGINEERING   (Bulgaria)

^c UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Ceramide; Erythrocyte membrane; Hypogonadal men; Membrane fluidity; Phosphatidylcholine; Phosphatidylethanolamine; Phospholipid and fatty acid composition; Sphingomyelin; Testosterone replacement therapy

Indexed keywords

CERAMIDE; CHOLESTEROL; PALMITIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; SPHINGOMYELIN; STEARIC ACID; TESTOSTERONE; TESTOSTERONE UNDECANOATE; UNSATURATED FATTY ACID;

ADULT; ANDROGEN THERAPY; ARTICLE; CASE REPORT; CELL LEVEL; CELL MEMBRANE FLUIDITY; CHOLESTEATOMA; ENZYME ACTIVITY; ERYTHROCYTE MEMBRANE; HUMAN; HUMAN CELL; HYPOGONADISM; LIPID COMPOSITION; MALE; PRIORITY JOURNAL;

ADULT; CERAMIDES; ERYTHROCYTE MEMBRANE; HUMANS; HYPOGONADISM; LIPID METABOLISM; MALE; MEMBRANE FLUIDITY; MIDDLE AGED; PHOSPHATIDYLETHANOLAMINES; SPHINGOMYELINS; TESTOSTERONE; THROMBOSIS;

EID: 84864863785     PISSN: 13685538     EISSN: 14730790     Source Type: Journal    
DOI: 10.3109/13685538.2012.693550     Document Type: Article

References (39)

1. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994;151:54-61.
2. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR; Baltimore Longitudinal Study of Aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 2001;86:724-731.
3. Gray A, Feldman HA, McKinlay JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: Results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 1991;73: 1016-1025.
4. Morales A, Lunenfeld B; International Society for the Study of the Aging Male. Investigation, treatment and monitoring of late-onset hypogonadism in males. Official recommendations of ISSAM. International Society for the Study of the Aging Male. Aging Male 2002;5:74-86.
5. Schubert M, Jockenh?el F. Late-onset hypogonadism in the aging male (LOH): Definition, diagnostic and clinical aspects. J Endocrinol Invest 2005;28:23-27.
6. Wang C, Nieschlag E, Swerdloff RS, Behre H, Hellstrom WJ, Gooren LJ, Kaufman JM, et al. ISA, ISSAM, EAU, EAA and ASA recommendations: Investigation, treatment and monitoring of late-onset hypogonadism in males. Aging Male 2009;12:5-12.
7. Araujo AB, Handelsman D, McKinlay JB. Total testosterone as a predictor of mortality in men: Results from the Massachusetts Male Aging Study. The endocrine society annual meeting, San Diego, CA, USA Program and Abstracts 2005; P1-561.
8. Hugh Jones T. Testosterone Associations with Erectile Dysfunction, Diabetes, and the Metabolic Syndrome. Eur Urol Suppl. 2007;6:847-857.
9. Pitteloud N, Mootha VK, Dwyer AA, Hardin M, Lee H, Eriksson KF, Tripathy D, et al. Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care 2005;28:1636-1642.
10. Ken FM. Testosterone and body functions. Aging Male 2006;9:183-188.
11. Fukui M, Kitagawa Y, Nakamura N, Kadono M, Mogami S, Hirata C, Ichio N, et al. Association between serum testosterone concentration and carotid atherosclerosis in men with type 2 diabetes. Diabetes Care 2003;26:1869-1873.
12. Oh JY, Barrett-Connor E, Wedick NM, Wingard DL; Rancho Bernardo Study. Endogenous sex hormones and the development of type 2 diabetes in older men and women: The Rancho Bernardo study. Diabetes Care 2002;25:55-60.
13. Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C. Prevalence of hypogonadism in males aged at least 45 years: The HIM study. Int J Clin Pract 2006;60:762-769.
14. Chahla EJ, Hayek ME, Morley JE. Testosterone replacement therapy and cardiovascular risk factors modification. Aging Male 2011;14:83-90.
15. Phillips GB, Pinkernell BH, Jing TY. The association of hypotestosteronemia with coronary artery disease in men. Arterioscler Thromb 1994;14:701-706.
16. Zitzmann M. Testosterone and the brain. Aging Male 2006;9:195-199.
17. Jankowska EA, Biel B, Majda J, Szklarska A, Lopuszanska M, Medras M, Anker SD, et al. Anabolic deficiency in men with chronic heart failure: Prevalence and detrimental impact on survival. Circulation 2006;114:1829-1837.
18. Whelton PK. Epidemiology of hypertension. Lancet 1994;344:101-106.
19. Zicha J, Kunes J, Devynck MA. Abnormalities of membrane function and lipid metabolism in hypertension: A review. Am J Hypertens 1999;12:315-331.
20. Hodgkin M, Craxton A, Parry JB, Hughes PJ, Potter BV, Michell RH, Kirk CJ. Bovine testis and human erythrocytes contain different subtypes of membrane-associated Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphomonoesterases. Biochem J 1994;297 (Pt 3):637-645.
21. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-917.
22. Touchstone J, Chen J, Beaver K. Improved separation of phospholipids by thin layer chromatography. Lipids 1980;15:61-62.
23. Kahovcov J, Odavic R. A simple method for the quantitative analysis of phospholipids separated by thin layer chromatography. J Chromatogr 1969;40:90-96.
24. Morrison W, Smith L. Preparation of fatty acid methyl esters from lipids with borontrifuoridemethanol. J Lipid Res 1964;5:600-608.
25. Nikolova-Karakashian M, Morgan ET, Alexander C, Liotta DC, Merrill AH Jr. Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11. J Biol Chem 1997;272:18718-18724.
26. Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M. Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. J Biol Chem 2000;275:3462-3468.
27. Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Pushkareva MYu, Obeid LM, Hannun YA. Role for ceramide in cell cycle arrest. J Biol Chem 1995;270:2047-2052.
28. Van Blitterswijk WJ, Van Hoeven RP, Van der Meer BW. Lipid structural order parameters (reciprocal of fluidity) in biomembranes derived from steady-state fluorescence polarization measurements. Biochim Biophys Acta 1981;644:323-332.
29. Calof OM, Singh AB, Lee ML, Kenny AM, Urban RJ, Tenover JL, Bhasin S. Adverse events associated with testosterone replacement in middleaged and older men: A meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci 2005;60:1451-1457.
30. Fern?dez-Balsells MM, Murad MH, Lane M, Lampropulos JF, Albuquerque F, Mullan RJ, Agrwal N, et al. Clinical review 1: Adverse effects of testosterone therapy in adult men: A systematic review and meta-analysis. J Clin Endocrinol Metab 2010;95:2560-2575.
31. Medeiros LC, Liu YW, Park S, Chang PH, Smith AM. Insulin, but not estrogen, correlated with indexes of desaturase function in obese women. Horm Metab Res 1995;27:235-238.
32. Ntambi JM. Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J Lipid Res 1999;40:1549-1558.
33. Garnier M, Attali JR, Valensi P, Delatour-Hanss E, Gaudey F, Koutsouris D. Erythrocyte deformability in diabetes and erythrocyte membrane lipid composition. Metab Clin Exp 1990;39:794-798.
34. Schmitz-Peiffer C, Craig DL, Biden TJ. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 1999;274:24202-24210.
35. Teruel T, Hernandez R, Lorenzo M. Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes 2001;50: 2563-2571.
36. Summers SA, Garza LA, Zhou H, Birnbaum MJ. Regulation of insulinstimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol Cell Biol 1998;18:5457-5464.
37. Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem 1996;271:13018-13022.
38. Nikolova-Karakashian M, Karakashian A, Rutkute K. Role of neutral sphingomyelinases in aging and inflammation. Subcell Biochem 2008; 49:469-486.
39. Holman RT, Johnson SB, Gerrard JM, Mauer SM, Kupcho-Sandberg S, Brown DM. Arachidonic acid deficiency in streptozotocin-induced diabetes. Proc Natl Acad Sci USA 1983;80:2375-2379.