The hybrid experimental simplex algorithm - An alternative method for 'sweet spot' identification in early bioprocess development: Case studies in ion exchange chromatography

Analytica Chimica Acta

Volumn 743, Issue , 2012, Pages 19-32

  Konstantinidis, Spyridon ^a   Chhatre, Sunil ^a   Velayudhan, Ajoy ^a   Heldin, Eva ^b   Titchener Hooker, Nigel ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GE Healthcare Life Sciences   (Sweden)

Author keywords

Analytical bottleneck; FAb'; Green fluorescent protein; High throughput process development; Ion exchange chromatography; Simplex algorithm

Indexed keywords

ANALYTICAL BOTTLENECK; FAB'; GREEN FLUORESCENT PROTEIN; ION EXCHANGE CHROMATOGRAPHY; PROCESS DEVELOPMENT; SIMPLEX ALGORITHM;

CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DESIGN OF EXPERIMENTS; ESCHERICHIA COLI; ION EXCHANGE RESINS; OPTIMIZATION; PH EFFECTS;

ALGORITHMS;

ANION EXCHANGE RESIN; CATION EXCHANGE RESIN; GREEN FLUORESCENT PROTEIN; SODIUM CHLORIDE;

ALGORITHM; ARTICLE; BACTERIUM CULTURE; BINDING AFFINITY; CELL LYSATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ESCHERICHIA COLI; HYBRID EXPERIMENTAL SIMPLEX ALGORITHM; ION EXCHANGE CHROMATOGRAPHY; NONHUMAN; PH; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS DEVELOPMENT; PROCESS TECHNOLOGY; PROTEIN BINDING; SALT LOADING;

ALGORITHMS; ANION EXCHANGE RESINS; BIOSENSING TECHNIQUES; CHROMATOGRAPHY, ION EXCHANGE; GREEN FLUORESCENT PROTEINS; HYDROGEN-ION CONCENTRATION;

ESCHERICHIA COLI;

EID: 84864853519     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2012.06.039     Document Type: Article

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