Framework for the rapid optimization of soluble protein expression in Escherichia coli combining microscale experiments and statistical experimental design

Biotechnology Progress

Volumn 23, Issue 4, 2007, Pages 785-793

  Islam, R S ^a   Tisi, D ^b   Levy, M S ^c   Lye, G J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ASTEX PHARMACEUTICALS   (United Kingdom)

^c Biogenesis Bago   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMASS; CELL CULTURE; CONCENTRATION (PROCESS); DRUG PRODUCTS; ESCHERICHIA COLI; FERMENTATION; OPTIMIZATION; STATISTICAL METHODS;

DRUG DISCOVERY; STATISTICAL DESIGN;

PROTEINS;

PROTEIN;

ARTICLE; BIOTECHNOLOGY; CHEMICAL MODEL; CHEMISTRY; COMPUTER PROGRAM; DRUG DESIGN; DRUG SCREENING; EQUIPMENT DESIGN; ESCHERICHIA COLI; FERMENTATION; GENETIC PROCEDURES; INSTRUMENTATION; METABOLISM; METHODOLOGY; PHARMACEUTICS; REGRESSION ANALYSIS; STATISTICAL MODEL;

BIOTECHNOLOGY; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; EQUIPMENT DESIGN; ESCHERICHIA COLI; FERMENTATION; GENETIC TECHNIQUES; MODELS, CHEMICAL; MODELS, STATISTICAL; PROTEINS; REGRESSION ANALYSIS; RESEARCH DESIGN; SOFTWARE; TECHNOLOGY, PHARMACEUTICAL;

ESCHERICHIA COLI;

EID: 34547878384     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp070059a     Document Type: Article

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