Radiation-induced early changes in the brain and behavior: Serial diffusion tensor imaging and behavioral evaluation after graded doses of radiation

Journal of Neuroscience Research

Volumn 90, Issue 10, 2012, Pages 2009-2019

  Trivedi, Richa ^a   Khan, Ahmad Raza ^a   Rana, Poonam ^a   Haridas, Seenu ^a   Hemanth Kumar, B S ^a   Manda, Kailash ^a   Rathore, Ram K S ^b   Tripathi, Rajendra P ^a   Khushu, Subash ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

Author keywords

Astrogliosis; Cognition; Fractional anisotropy; Mean diffusivity

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; BEHAVIOR DISORDER; CAUDATE NUCLEUS; CEREBRAL PEDUNCLE; CINGULATE GYRUS; COGNITIVE DEFECT; CONTROLLED STUDY; CORPUS CALLOSUM; DIFFUSION; DIFFUSION TENSOR IMAGING; EXPLORATORY BEHAVIOR; FRACTIONAL ANISOTROPY; FRONTAL CORTEX; GAMMA IRRADIATION; HIPPOCAMPUS; HYPOTHALAMUS; MALE; MEAN DIFFUSIVITY; MONITORING; MOOD DISORDER; MOUSE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; PUTAMEN; RADIATION DOSE; RADIATION INJURY; RADIATION RESPONSE; RECOGNITION; SENSORIMOTOR CORTEX; THALAMUS; WHOLE BODY RADIATION;

ANIMALS; ANISOTROPY; BEHAVIOR, ANIMAL; BRAIN; BRAIN MAPPING; DIFFUSION TENSOR IMAGING; DOSE-RESPONSE RELATIONSHIP, RADIATION; EXPLORATORY BEHAVIOR; GAMMA RAYS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED A; RECOGNITION (PSYCHOLOGY);

EID: 84864842030     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23073     Document Type: Article

References (44)

1. Ahlhelm F, Schneider G, Backens M, Reith W, Hagen T. 2002. Time course of the apparent diffusion coefficient after cerebral infarction. Eur Radiol 12: 2322-2329.
2. Basser PJ, Pierpaoli C. 1998. A simplified method to measure the diffusion tensor from seven MR images. Magn Reson Med 39: 928-934.
3. Benczik J, Tenhunen M, Snellman M, Joensuu H, Färkkilä M, Joensuu R, Abo Ramadan U, Kallio M, deGritz B, Morris GM, Hopewell JW. 2002. Late radiation effects in the dog brain: correlation of MRI and histological changes. Radiother Oncol 63: 107-120.
4. Calvo W, Hopewell JW, Reinhold HS, Yeung TK. 1988. Time- and dose-related changes in the white matter of the rat brain after single doses of X rays. Br J Radiol 61: 1043-1052.
5. Catani M. 2006. Diffusion tensor magnetic resonance imaging tractography in cognitive disorders. Curr Opin Neurol 19: 599-606.
6. Coyle JT, Puttfarcken P. 1993. Oxidative stress, glutamate, and neurodegenerative disorders. Science 262: 689-695.
7. DeBoy CA, Zhang J, Dike S, Shats I, Jones M, Reich DS, Mori S, Nguyen T, Rothstein B, Miller RH, Griffin JT, Kerr DA, Calabresi PA. 2007. High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord. Brain 130: 2199-2210.
8. Harsan LA, Poulet P, Guignard B, Parizel N, Skoff RP, Ghandour MS. 2007. Astrocytic hypertrophy in dysmyelination influences the diffusion anisotropy of white matter. J Neurosci Res 85: 935-944.
9. Hellström NA, Björk-Eriksson T, Blomgren K, Kuhn HG. 2009. Differential recovery of neural stem cells in the subventricular zone and dentate gyrus after ionizing radiation. Stem Cells 27: 634-641.
10. Herrmann JE, Imura T, Song B, Qi J, Ao Y, Nguyen TK, Korsak RA, Takeda K, Akira S, Sofroniew MV. 2008. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci 28: 7231-7243.
11. Hopewell JW. 1979. Late radiation damage to the central nervous system: a radiobiological interpretation. Neuropathol Appl Neurobiol 5: 329-343.
12. Hopewell JW, van der Kogel AJ. 1999. Pathophysiological mechanisms leading to the development of late radiation-induced damage to the central nervous system. Front Radiat Ther Oncol 33: 265-275.
13. Jenrow KA, Brown SL, Liu J, Kolozsvary A, Lapanowski K, Kim JH. 2010. Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus. Radiat Oncol 5: 6.
14. Johansen-Berg H, Behrens TE. 2006. Just pretty pictures? What diffusion tractography can add in clinical neuroscience. Curr Opin Neurol 19: 379-385.
15. Kennedy AS, Archambeau JO, Archambeau MH, Holshouser B, Thompson J, Moyers M, Hinshaw DJr, Slater JM. 1995. Magnetic resonance imaging as a monitor of changes in the irradiated rat brain. An aid in determining the time course of events in a histologic study. Invest Radiol 30: 214-220.
16. Khong PL, Kwong DL, Chan GC, Sham JS, Chan FL, Ooi GC. 2003. Diffusion-tensor imaging for the detection and quantification of treatment-induced white matter injury in children with medulloblastoma: a pilot study. AJNR Am J Neuroradiol 24: 734-740.
17. Khong PL, Leung LH, Chan GC, Kwong DL, Wong WH, Cao G, Ooi GC. 2005. White matter anisotropy in childhood medulloblastoma survivors: association with neurotoxicity risk factors. Radiology 236: 647-652.
18. Kitahara S, Nakasu S, Murata K, Sho K, Ito R. 2005. Evaluation of treatment-induced cerebral white matter injury by using diffusion-tensor MR imaging: initial experience. AJNR Am J Neuroradiol 26: 2200-2206.
19. Kurita H, Kawahara N, Asai A, Ueki K, Shin M, Kirino T. 2001. Radiation-induced apoptosis of oligodendrocytes in the adult rat brain. Neurol Res 23: 869-874.
20. Le Bihan D. 2007. The "wet mind": water and functional neuroimaging. Physiol Med Biol 52: R57-R90.
21. Li YQ, Chen P, Haimovitz-Friedman A, Reilly RM, Wong CS. 2003. Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation. Cancer Res 63: 5950-5956.
22. Malik GK, Trivedi R, Gupta A, Singh R, Prasad KN, Gupta RK. 2008. Quantitative DTI assessment of periventricular white matter changes in neonatal meningitis. Brain Dev 30: 334-341.
23. Manda K, Reiter RJ. 2010. Melatonin maintains adult hippocampal neurogenesis and cognitive functions after irradiation. Prog Neurobiol 90: 60-68.
24. Matés JM, Pérez-Gómez C, Núñez de Castro I. 1999. Antioxidant enzymes and human diseases. Clin Biochem 32: 595-603.
25. Münter MW, Karger CP, Reith W, Schneider HM, Peschke P, Debus J. 1999. Delayed vascular injury after single high-dose irradiation in the rat brain: histologic immunohistochemical, and angiographic studies. Radiology 212: 475-482.
26. Price RE, Langford LA, Jackson EF, Stephens LC, Tinkey PT, Ang KK. 2001. Radiation-induced morphologic changes in the rhesus monkey (Macaca mulatta) brain. J Med Primatol 30: 81-87.
27. Raber J, Rola R, LeFevour A, Morhardt D, Curley J, Mizumatsu S, VandenBerg SR, Fike JR. 2004. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res 162: 39-47.
28. Reinhold HS, Calvo W, Hopewell JW, van der Berg AP. 1990. Development of blood vessel-related radiation damage in the fimbria of the central nervous system. Int J Radiat Oncol Biol Phys 18: 37-42.
29. Roitbak T, Syková E. 1999. Diffusion barriers evoked in the rat cortex by reactive astrogliosis. Glia 28: 40-48.
30. Rubin P, Gash DM, Hansen JT, Nelson DF, Williams JP. 1994. Disruption of the blood-brain barrier as the primary effect of CNS irradiation. Radiother Oncol 31: 51-60.
31. Saksena S, Rai V, Saraswat VA, Rathore RS, Purwar A, Kumar M, Thomas MA, Gupta RK. 2008. Cerebral diffusion tensor imaging and in vivo proton magnetic resonance spectroscopy in patients with fulminant hepatic failure. J Gastroenterol Hepatol 23: e111-e119.
32. Schultheiss TE, Stephens LC. 1992. Invited review: permanent radiation myelopathy. Br J Radiol 65: 737-753.
33. Sofroniew MV. 2009. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 32: 638-647.
34. Sun SW, Liang HF, Trinkaus K, Cross AH, Armstrong RC, Song SK. 2006. Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum. Magn Reson Med 55: 302-308.
35. Syková E, Svoboda J, Simonová Z, Lehmenkühler A, Lassmann H. 1996. X-irradiation-induced changes in the diffusion parameters of the developing rat brain. Neuroscience 70: 597-612.
36. Trivedi R, Gupta RK, Shah V, Tripathi M, Rathore RK, Kumar M, Pandey CM, Narayana PA. 2008. Treatment-induced plasticity in cerebral palsy: a diffusion tensor imaging study. Pediatr Neurol 39: 341-349.
37. Trivedi R, Agarwal S, Rathore RK, Saksena S, Tripathi RP, Malik GK, Pandey CM, Gupta RK. 2009. Understanding development and lateralization of major cerebral fiber bundles in pediatric population through quantitative diffusion tensor tractography. Pediatr Res 66: 636-641.
38. Vorísek I, Hájek M, Tintera J, Nicolay K, Syková E. 2002. Water ADC, extracellular space volume, and tortuosity in the rat cortex after traumatic injury. Magn Reson Med 48: 994-1003.
39. Wang S, Wu EX, Tam CN, Lau HF, Cheung PT, Khong PL. 2008. Characterization of white matter injury in a hypoxic-ischemic neonatal rat model by diffusion tensor MRI. Stroke 39: 2348-2353.
40. Wang S, Wu EX, Qiu D, Leung LH, Lau HF, Khong PL. 2009. Longitudinal diffusion tensor magnetic resonance imaging study of radiation-induced white matter damage in a rat model. Cancer Res 69: 1190-1198.
41. Welzel T, Niethammer A, Mende U, Heiland S, Wenz F, Debus J, Krempien R. 2008. Diffusion tensor imaging screening of radiation-induced changes in the white matter after prophylactic cranial irradiation of patients with small cell lung cancer: first results of a prospective study. AJNR Am J Neuroradiol 29: 379-383.
42. Wilhelmsson U, Bushong EA, Price DL, Smarr BL, Phung V, Terada M, Ellisman MH, Pekny M. 2006. Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury. Proc Natl Acad Sci U S A 103: 17513-17518.
43. Wong CS, Van der Kogel AJ. 2004. Mechanisms of radiation injury to the central nervous system: implications for neuroprotection. Mol Interv 4: 273-284.
44. Yang T, Wu SL, Liang JC, Rao ZR, Ju G. 2000. Time-dependent astroglial changes after gamma knife radiosurgery in the rat forebrain. Neurosurgery 47: 407-415.