High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord

Brain

Volumn 130, Issue 8, 2007, Pages 2199-2210

  DeBoy, Cynthia A ^a   Zhang, Jiangyang ^a   Dike, Sonny ^b   Shats, Irina ^b   Jones, Melina ^a   Reich, Daniel S ^a   Mori, Susumu ^a   Nguyen, Thien ^a   Rothstein, Brian ^c   Miller, Robert H ^c   Griffin, John T ^a   Kerr, Douglas A ^a,b   Calabresi, Peter A ^a,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Axonal degeneration; Demyelinating disease; MRI; Neuroimaging; Spinal cord

Indexed keywords

ALLERGIC ENCEPHALOMYELITIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; DIFFUSION TENSOR IMAGING; FEMALE; FUNCTIONAL DISEASE; HISTOPATHOLOGY; NERVE FIBER DEGENERATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; SPINAL CORD LESION;

ANIMALS; AXONS; CELL COUNT; DIFFUSION MAGNETIC RESONANCE IMAGING; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; MICROSCOPY, ELECTRON; MULTIPLE SCLEROSIS; MYELIN SHEATH; PHOSPHORYLATION; RATS; RATS, INBRED LEW; SPINAL CORD;

EID: 34547747932     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awm122     Document Type: Article

References (33)

1. Ahrens ET, Laidlaw DH, Readhead C, Brosnan CF, Fraser SE, Jacobs RE. MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis. Magn Reson Med 1998; 40: 119-32.
2. Archer DR, Watson DF, Griffin JW. Phosphorylation-dependent immunoreactivity of neurofilaments and the rate of slow axonal transport in the central and peripheral axons of the rat dorsal root ganglion. J Neurochem 1994; 62: 1119-25.
3. Arnold DL. Changes observed in multiple sclerosis using magnetic resonance imaging reflect a focal pathology distributed along axonal pathways. J Neurol 2005; 252 (Suppl 5): v25-9.
4. Bambakidis NC, Wang RZ, Franic L, Miller RH. Sonic hedgehog-induced neural precursor proliferation after adult rodent spinal cord injury. J Neurosurg 2003; 99: 70-5.
5. Basser PJ. Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed 1995; 8: 333-44.
6. Basser PJ, Mattiello J, LeBihan D. Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 1994; 103: 247-54.
7. Beaulieu C, Allen PS. Water diffusion in the giant axon of the squid: implications for diffusion-weighted MRI of the nervous system. Magn Reson Med 1994; 32: 579-83.
8. Bjartmar C, Wujek JR, Trapp BD. Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J Neurol Sci 2003; 206: 165-71.
9. Bjartmar C, Yin X, Trapp BD. Axonal pathology in myelin disorders. J Neurocytol 1999; 28: 383-95.
10. Blakemore WF, Eames RA, Smith KJ, McDonald WI. Remyelination in the spinal cord of the cat following intraspinal injections of lysolecithin. J Neurol Sci 1977; 33: 31-43.
11. D'Arceuil HE, Westmoreland S, de Crespigny AJ. An approach to high resolution diffusion tensor imaging in fixed primate brain. Neuroimage 2007; 35: 553-65.
12. Felts PA, Woolston AM, Fernando HB, Asquith S, Gregson NA, Mizzi OJ, et al. Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide. Brain 2005; 128: 1649-66.
13. Ferguson B, Matyszak MK, Esiri MM, Perry VH. Axonal damage in acute multiple sclerosis lesions. Brain 1997; 120 (Pt 3): 393-9.
14. Harsan LA, Poulet P, Guignard B, Steibel J, Parizel N, de Sousa PL, et al. Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging. J Neurosci Res 2006; 83: 392-402.
15. Jeong EK, Kim SE, Guo J, Kholmovski EG, Parker DL. High-resolution DTI with 2D interleaved multislice reduced FOV single-shot diffusion-weighted EPI (2D ss-rFOV-DWEPI). Magn Reson Med 2005; 54: 1575-9.
16. Kerschensteiner M, Stadelmann C, Buddeberg BS, Merkler D, Bareyre FM, Anthony DC, et al. Targeting experimental autoimmune encephalomyelitis lesions to a predetermined axonal tract system allows for refined behavioral testing in an animal model of multiple sclerosis. Am J Pathol 2004; 164: 1455-69.
17. Kim JH, Budde MD, Liang HF, Klein RS, Russell JH, Cross AH, et al. Detecting axon damage in spinal cord from a mouse model of multiple sclerosis. Neurobiol Dis 2006; 21: 626-32.
18. MacKenzie-Graham A, Tinsley MR, Shah KP, Aguilar C, Strickland LV, Boline J, et al. Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis. Neuroimage 2006; 32: 1016-23.
19. Mori S, van Zijl PC. Fiber tracking: principles and strategies - a technical review. NMR Biomed 2002; 15: 468-80.
20. Mori S, Zhang J. Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron 2006; 51: 527-39.
21. Papanikolaou N, Karampekios S, Papadaki E, Malamas M, Maris T, Gourtsoyiannis N. Fractional anisotropy and mean diffusivity measurements on normal human brain: comparison between low-and high-resolution diffusion tensor imaging sequences. Eur Radiol 2006; 16: 187-92.
22. Peterson JW, Trapp BD. Neuropathobiology of multiple sclerosis. Neurol Clin 2005; 23: 107-29vi-vii.
23. Reich DS, Smith SA, Jones CK, Zackowski KM, van Zijl PC, Calabresi PA, et al. Quantitative characterization of the corticospinal tract at 3T. AJNR Am J Neuroradiol 2006; 27: 2168-78.
24. Schmierer K, Wheeler-Kingshott CA, Boulby PA, Scaravilli F, Altmann DR, Barker GJ, et al. Diffusion tensor imaging of post mortem multiple sclerosis brain. Neuroimage 2007; 35: 467-77.
25. Simon JH, Kinkel RP, Jacobs L, Bub L, Simonian N. A Wallerian degeneration pattern in patients at risk for MS. Neurology 2000; 54: 1155-60.
26. Simon JH, Zhang S, Laidlaw DH, Miller DE, Brown M, Corboy J, et al. Identification of fibers at risk for degeneration by diffusion tractography in patients at high risk for MS after a clinically isolated syndrome. J Magn Reson Imaging 2006; 24: 983-8.
27. Smith SA, Farrell JA, Jones CK, Reich DS, Calabresi PA, van Zijl PC. Pulsed magnetization transfer imaging with body coil transmission at 3 Tesla: feasibility and application. Magn Reson Med 2006; 56: 866-75.
28. Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage 2003; 20: 1714-22.
29. Song SK, Yoshino J, Le TQ, Lin SJ, Sun SW, Cross AH, et al. Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 2005; 26: 132-40.
30. Sun SW, Neil JJ, Song SK. Relative indices of water diffusion anisotropy are equivalent in live and formalin-fixed mouse brains. Magn Reson Med 2003; 50: 743-8.
31. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998; 338: 278-85.
32. Tsunoda I, Fujinami RS. Inside-out versus outside-in models for virus induced demyelination: axonal damage triggering demyelination. Springer Semin Immunopathol 2002; 24: 105-25.
33. Xue R, van Zijl PC, Crain BJ, Solaiyappan M, Mori S. In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging. Magn Reson Med 1999; 42: 1123-7.