Molecular profiling of oral microbiota in jawbone samples of bisphosphonate-related osteonecrosis of the jaw

Oral Diseases

Volumn 18, Issue 6, 2012, Pages 602-612

  Wei, X ^a   Pushalkar, S ^a   Estilo, C ^b   Wong, C ^a   Farooki, A ^b   Fornier, M ^b   Bohle, G ^b   Huryn, J ^b   Li, Y ^a   Doty, S ^c   Saxena, D ^a  

^a NEW YORK UNIVERSITY COLLEGE OF DENTISTRY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

16S rDNA; Bisphosphonate; Denaturing gradient gel electrophoresis; Microbial shift; Osteomyelitis; Osteonecrosis of the jaw

Indexed keywords

GENOMIC DNA;

ADULT; AGED; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM; BACTERIUM DETECTION; DENATURING GRADIENT GEL ELECTROPHORESIS; DNA EXTRACTION; EUBACTERIUM; FEMALE; FUSOBACTERIUM; HUMAN; HUMAN TISSUE; JAW; JAW OSTEONECROSIS; LACTOBACILLUS GASSERI; MALE; MOUTH FLORA; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOMYELITIS; PARVIMONAS; PHYLOGENY; PRIORITY JOURNAL; PSEUDORAMIBACTER ALACTOLYTICUS; STREPTOCOCCUS MITIS; UNINDEXED SEQUENCE;

ADULT; AGED; ANTINEOPLASTIC AGENTS; BACTERIA; BIODIVERSITY; BIOFILMS; BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS OF THE JAW; BONE DENSITY CONSERVATION AGENTS; DIPHOSPHONATES; DNA FINGERPRINTING; EUBACTERIUM; FEMALE; FUSOBACTERIUM; HUMANS; LACTOBACILLUS; MALE; MANDIBULAR DISEASES; MAXILLARY DISEASES; MIDDLE AGED; MOUTH; PEPTOSTREPTOCOCCUS; PHYLOGENY; PORPHYROMONAS; PREVOTELLA; RNA, RIBOSOMAL, 16S; STREPTOCOCCUS;

EID: 84864838010     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2012.01916.x     Document Type: Article

References (64)

1. Aghaloo TL, Felsenfeld AL, Tetradis S (2010). Osteonecrosis of the jaw in a patient on denosumab. J Oral Maxillofac Surg 68: 959-963.
2. Allen M, Burr D (2009). The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data. J Oral Maxillofac Surg 67: 61-70.
3. Aspenberg P (2006). Osteonecrosis of the jaw: what do bisphosphonates do? Expert Opin Drug Saf 5: 743-745.
4. Bi Y, Gao Y, Ehirchiou D et al (2010). Bisphosphonates cause osteonecrosis of the jaw-like disease in mice. Am J Pathol 177: 280-290.
5. Bisiaux-Salauze B, Perez C, Sebald M, Petit JC (1990). Bacteremias caused by Selenomonas artemidis and Selenomonas infelix. J Clin Microbiol 28: 140-142.
6. Brinig M, Lepp P, Ouverney C, Armitage G, Relman D (2003). Prevalence of bacteria of division TM7 in human subgingival plaque and their association with disease. Appl Environ Microbiol 69: 1687-1694.
7. Carlier J-P, K'Ouas GN, Bonne I, Lozniewski A, Mory F (2004). Oribacterium sinus gen. nov., sp. nov., within the family 'Lachnospiraceae' (phylum Firmicutes). Int J Syst Evol Microbiol 54: 1611-1615.
8. Carlier J-P, K'Ouas G, Han XY (2007). Moryella indoligenes gen. nov., sp. nov., an anaerobic bacterium isolated from clinical specimens. Int J Syst Evol Microbiol 57: 725-729.
9. Cremers S, Farooki A (2011). Biochemical markers of bone turnover in osteonecrosis of the jaw in patients with osteoporosis and advanced cancer involving the bone. Ann N Y Acad Sci 1218: 80-87.
10. DeSantis TZ, Hugenholtz P, Larsen N et al (2006a). Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol 72: 5069-5072.
11. DeSantis T, Hugenholtz P, Keller K et al (2006b). NAST: a multiple sequence alignment server for comparative analysis of 16S rRNA genes. Nucleic Acids Res 34: 394-399.
12. Dewhirst FE, Chen T, Izard J et al (2010). The human oral microbiome. J Bacteriol 192: 5002-5017.
13. Durie B, Katz M, Crowley J (2005). Osteonecrosis of the jaw and bisphosphonates. N Engl J Med 353: 99-102, discussion 99-102.
14. Estilo CL, Van Poznak CH, Wiliams T et al (2008). Osteonecrosis of the maxilla and mandible in patients with advanced cancer treated with bisphosphonate therapy. Oncologist 13: 911-920.
15. Filleul O, Crompot E, Saussez S (2010). Bisphosphonate-induced osteonecrosis of the jaw: a review of 2, 400 patient cases. J Cancer Res Clin Onocol 136: 1117-1124.
16. Fine D, Furgang D, Schreiner H et al (1999). Phenotypic variation in Actinobacillus actinomycetemcomitans during laboratory growth: implications for virulence. Microbiology 145(Pt 6): 1335-1347.
17. Gomes BPFA, Jacinto RC, Pinheiro ET et al (2005). Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella intermedia and Prevotella nigrescens in endodontic lesions detected by culture and by PCR. Oral Microbiol Immunol 20: 211-215.
18. Good I (1953). The population frequencies of species and the estimation of population parameters. Biometrika 40: 237-264.
19. Grötz K, Walter C, Küttner C, Al-Nawas B (2007). [Relevance of bisphosphonate long-term therapy in radiation therapy of endosteal jaw metastases]. Strahlenther Onkol 183: 190-194.
20. Hammer Ø, Harper D, Ryan P (2001). PAST: Paleontological Statistics Software Package for Education and data analysis. Palaeontologia Electronica 4: 9.
21. Hansen T, Kunkel M, Weber A, James Kirkpatrick C (2006). Osteonecrosis of the jaws in patients treated with bisphosphonates - histomorphologic analysis in comparison with infected osteoradionecrosis. J Oral Pathol Med 35: 155-160.
22. Heitz-Mayfield LJ, Lang NP (2010). Comparative biology of chronic and aggressive periodontitis vs. peri-implantitis. Periodontol 2000: 53. 167-81.
23. Hoefert S, Eufinger H (2011). Relevance of a prolonged preoperative antibiotic regime in the treatment of bisphosphonate-related osteonecrosis of the jaw. J Oral Maxillofac Surg 69: 362-380.
24. Hoefert S, Schmitz I, Tannapfel A, Eufinger H (2010). Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw: a possible pathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jaw based on scanning electron microscopy findings. Clin Oral Investig 14: 271-284.
25. Ji X, Pushalkar S, Li Y, Glickman R, Fleisher K, Saxena D (2012). Antibiotic effects on bacterial profile in osteonecrosis of the jaw. Oral Dis 18: 85-95.
26. Kaplan I, Anavi K, Anavi Y et al (2009). The clinical spectrum of actinomyces-associated lesions of the oral mucosa and jawbones: correlations with histomorphometric analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108: 738-746.
27. Kemp P, Aller Y (2004). Estimating prokaryotic diversity: when are 16S rDNA libraries large enough? Limnol Oceanogr Methods 2: 114-125.
28. Kos M (2011). Bisphosphonates promote jaw osteonecrosis through facilitating bacterial colonisation. Med Hypotheses 77: 214-215.
29. Kos M, Luczak K (2009). Bisphosphonates promote jaw osteonecrosis through facilitating bacterial colonisation. Bio Hypotheses 2: 34-36.
30. Kosmidis CI, Chandrasekar PH (2012). Management of gram-positive bacterial infections in cancer patients. Leuk Lymphoma 53: 8-18.
31. Krebs CJ (1989). Ecol methodol. Harper & Row: New York, NY.
32. Kumar P, Griffen A, Moeschberger M, Leys E (2005). Identification of candidate periodontal pathogens and beneficial species by quantitative 16S clonal analysis. J Clin Microbiol 43: 3944-3955.
33. Kumar SK, Gorur A, Schaudinn C, Shuler CF, Costerton JW, Sedghizadeh PP (2010). The role of microbial biofilms in osteonecrosis of the jaw associated with bisphosphonate therapy. Curr Osteoporos Rep 8: 40-48.
34. Lane D (1991). 16S/23S rRNA sequencing. In: Stackebrandt E, Goodfellow M, eds Nucleic acid techniques in bacterial systematics. John Wiley & Sons: New York, NY, pp. 115-175.
35. Ledder RG, Gilbert P, Huws SA et al (2007). Molecular analysis of the subgingival microbiota in health and disease. Appl Environ Microbiol 73: 516-523.
36. Lesclous P, Abi NS, Carrel JP et al (2009). Bisphosphonate-associated osteonecrosis of the jaw: a key role of inflammation? Bone 45: 843-852.
37. Levy P-Y, Fenollar F, Stein A, Borrione F, Raoult D (2009). Finegoldia magna: a forgotten pathogen in prosthetic joint infection rediscovered by molecular biology. Clin Infect Dis 49: 1244-1247.
38. Li Y, Ku C, Xu J, Saxena D, Caufield P (2005). Survey of oral microbial diversity using PCR-based denaturing gradient gel electrophoresis. J Dent Res 84: 559-564.
39. Li Y, Saxena D, Barnes V, Trivedi H, Ge Y, Xu T (2006). Polymerase chain reaction-based denaturing gradient gel electrophoresis in the evaluation of oral microbiota. Oral Microbiol Immunol 21: 333-339.
40. Li Y, Ge Y, Saxena D, Caufield P (2007). Genetic profiling of the oral microbiota associated with severe early-childhood caries. J Clin Microbiol 45: 81-87.
41. Maidak B, Cole J, Lilburn T et al (2001). The RDP-II (Ribosomal Database Project). Nucleic Acids Res 29: 173-174.
42. Naik NH, Russo TA (2009). Bisphosphonate-related osteonecrosis of the jaw: the role of actinomyces. Clin Infect Dis 49: 1729-1732.
43. Olson JB, Harmody DK, Bej AK, McCarthy PJ (2007). Tsukamurella spongiae sp. nov., a novel actinomycete isolated from a deep-water marine sponge. Int J Syst Evol Microbiol 57: 1478-1481.
44. Otto S, Hafner S, Mast G et al (2010). Bisphosphonate-related osteonecrosis of the jaw: is pH the missing part in the pathogenesis puzzle? J Oral Maxillofac Surg 68: 1158-1161.
45. Ouverney C, Armitage G, Relman D (2003). Single-cell enumeration of an uncultivated TM7 subgroup in the human subgingival crevice. Appl Environ Microbiol 69: 6294-6298.
46. Paster B, Boches S, Galvin J et al (2001). Bacterial diversity in human subgingival plaque. J Bacteriol 183: 3770-3783.
47. Pei Z, Bini E, Yang L, Zhou M, Francois F, Blaser M (2004). Bacterial biota in the human distal esophagus. Proc Natl Acad Sci U S A 101: 4250-4255.
48. Reid IR (2009). Osteonecrosis of the jaw: who gets it, and why? Bone 44: 4-10.
49. Ricucci D, Siqueira J (2008). Anatomic and microbiologic challenges to achieving success with endodontic treatment: a case report. J Endod 34: 1249-1254.
50. Rokadiya S, Malden N (2008). An implant periapical lesion leading to acute osteomyelitis with isolation of Staphylococcus aureus. Br Dent J 205: 489-491.
51. Ruggiero S, Mehrotra B, Rosenberg T, Engroff S (2004). Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg 62: 527-534.
52. Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B (2009). American association of oral and maxillofacial surgeons position paper on bisphosphonate-related osteonecrosis of the Jawsâ€"2009 update. J Oral Maxillofac Surg 67: 2-12.
53. Rupf S, Merte K, Eschrich K (1999). Quantification of bacteria in oral samples by competitive polymerase chain reaction. J Dent Res 78: 850-856.
54. Sakamoto M, Siqueira JF Jr, Rôças IN, Benno Y (2008). Molecular analysis of the root canal microbiota associated with endodontic treatment failures. Oral Microbiol Immunol 23: 275-281.
55. Sedghizadeh P, Kumar S, Gorur A, Schaudinn C, Shuler C, Costerton J (2008). Identification of microbial biofilms in osteonecrosis of the jaws secondary to bisphosphonate therapy. J Oral Maxillofac Surg 66: 767-775.
56. Sedghizadeh P, Kumar S, Gorur A, Schaudinn C, Shuler C, Costerton J (2009). Microbial biofilms in osteomyelitis of the jaw and osteonecrosis of the jaw secondary to bisphosphonate therapy. J Am Dent Assoc 140: 1259-1265.
57. Sehbai A, Mirza M, Ericson S, Marano G, Hurst M, Araham J (2007). Osteonecrosis of the jaw associated with bisphosphonate therapy: tips for the practicing oncologist. Community Oncol 4: 47-52.
58. Sheffield V, Cox D, Lerman L, Myers R (1989). Attachment of a 40-base-pair G+C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes. Proc Natl Acad Sci U S A 86: 232-236.
59. Slots J, Ting M (1999). Actinobacillus actinomycetemcomitans and porphyromonas gingivalis in human periodontal disease: occurrence and treatment. Periodontol 2000(20): 82-121.
60. Street J, Bao M, deGuzman L et al (2002). Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci U S A 99: 9656-9661.
61. Tonetti M, Mombelli A (1999). Early-onset periodontitis. Ann Periodontol 4: 39-53.
62. Vassiliou V, Tselis N, Kardamakis D (2010). Osteonecrosis of the jaws: clinicopathologic and radiologic characteristics, preventive and therapeutic strategies. Strahlenther Onkol 186: 367-373.
63. Vickerman M, Brossard K, Funk D, Jesionowski A, Gill S (2007). Phylogenetic analysis of bacterial and archaeal species in symptomatic and asymptomatic endodontic infections. J Med Microbiol 56: 110-118.
64. Woo S, Hellstein J, Kalmar J (2006). Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann Intern Med 144: 753-761.