The aging of the endocrine hypothalamus and its dependent endocrine glands

Hormones

Volumn 11, Issue 3, 2012, Pages 241-253

  Batrinos, Menelaos L ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Adrenals; Aging; Endocrine hypothalamus; Gonads; Hypophysis; Thyroid

Indexed keywords

ALDOSTERONE; ANDROSTENEDIONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; FOLLITROPIN; GHRELIN; GONADORELIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; LIOTHYRONINE; LUTEINIZING HORMONE; PRASTERONE; PRASTERONE SULFATE; PROLACTIN; PROLACTOSTATIN; PROOPIOMELANOCORTIN; PROTIRELIN; SEX HORMONE BINDING PROTEIN; SOMATOMEDIN C; SOMATOSTATIN; TESTOSTERONE; THYROTROPIN; THYROXINE; VASOPRESSIN;

ACTH SECRETING CELL; ADRENOPAUSE; AGING; ANDROPAUSE; CELL STIMULATION; ENDOCRINE DISEASE; ENDOCRINE FUNCTION; ENDOCRINE GLAND; FEMALE GENITAL SYSTEM; GENITAL SYSTEM FUNCTION; HORMONAL THERAPY; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; HYPOPHYSIS; HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIFESPAN; MENOPAUSE; NERVE CELL; OVARY FOLLICLE; PROLACTIN SECRETING CELL; PUBERTY; REVIEW; SLEEP; SOMATOPAUSE;

EID: 84864836268     PISSN: 11093099     EISSN: None     Source Type: Journal    
DOI: 10.14310/horm.2002.1354     Document Type: Review

References (57)

1. Carlson E, Gillin J, Gorden P, Snyder F, 1972 Absence of sleep-related growth hormone peaks in aged. J Clin Endocrinol Metab 34: 1102.
2. Finkelstein JW, Roffwarg HP, Boyar RM, Kream J, Hellman L, 1972 Age-related change in the twenty-four hour spontaneous secretion of growth hormone. J Clin Endocrinol Metab 35: 665-670.
3. Rudman D, Kutner MH, Rogers OM, et al, 1981 Impaired growth hormone secretion in the adult population. J Clin Invest 67: 1361-1369.
4. Zadik Z, Chalew A, McCarter RJ, et al, 1985 The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab 60: 513-516.
5. Vermeulen A, 1987 Nyctohemeral growth hormone profiles in young and aged men: Correlation with somatomedin-C levels. J Clin Endocrinol Metab 64: 884-888.
6. Ho KY, Ewans WS, Blizzard RM, et al, 1987 Effects of sex and age on the 24-hour profile of growth hormone secretion in Man: Importance of endogenous estradiol concentrations. J Clin Endocrinol Metab 64: 51-56.
7. Tranmanesh A, Lizarralde G, Veldhuis JD, 1991 Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab 73: 1081-1088.
8. Corpas E, Harman SM, Blackman MR, 1993 Human growth hormone and human aging. Endocrine Rev 14: 20-39.
9. Lang I, Schernthaner G, Pietschmann P, 1987 Effects of sex and age on growth hormone response to growth hormone-releasing hormone in healthy individuals. J Clin Endocrinol Metab 65: 535-554.
10. Iovino ME, Monteleone P, Steardo L, 1989 Repetitive growth hormone-releasing hormone administration restores the attenuated growth hormone (GH) response to GH-releasing hormone testing in normal aging. J Clin Endocrinol Metab 69: 910-913.
11. Vekeman S, Robyn C, 1995 Influence of age on serum prolactin levels in women and men. Brit Med J 4: 738-739.
12. Yamaji T, Shimamoto K, Ishibashi M, 1976 Effect of age and sex on circulating and pituitary prolactin levels in human. Acta Endocrinol 83: 711-719.
13. Blackman MR, Kowatch MA, Wehmann RE, Harman SM, 1986 Basal serum prolactin levels and prolactin responses to constant infusions of thyrotropin releasing hormone in healthy aging men. J Gerontol 41: 699-705.
14. Sawin CT, Carlson HE, Geller A, et al, 1989 Serum prolactin and aging: basal values and changes with estrogen use and hypothyroidism. J Gerontol 44:M131-M135.
15. Greenspan SL, Klibanski A, Rowe JW, Elahi D, 1990 Age alters pulsatile prolactin release: Influence of dopaminergic inhibition. Am J Physiol 258:E799-804.
16. Feldman HA, Longcope C, Derby CA, et al, 2002 Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 87: 589-598.
17. Mariotti S, Franceschi C, Cossarizza A, Pinchera ND, 1993 The aging thyroid. Endocrine Rev 16: 686-715.
18. Peeters RP, 2008 Thyroid hormones and aging. Hormones (Athens) 7: 28-35.
19. Surks M, Ortiz E, Daniels GH, 2004 Subclinical thyroid disease. JAMA 291: 228-238.
20. Parle JV, Franklyn JA, Cross KW, et al, 1991 Prevalence and follow-up of abnormal thyrotrophin (TSH) concentrations in the elderly in the United Kingdom. Clin Endocrinol 34: 77-83.
21. Surks M, Hollowell G, et al, 2007 Age-specific distribution of serum thyrotropin and antithyroid antibodies in the U.S. population: Implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metab 92: 4575-4582.
22. Erfurth EM, Norden NE, Hedner P, et al, 1984 Normal reference interval for thyrotropin response to thyroliberin: Dependence on age, sex, free thyroxin index, and basal concentrations of thyrotropin. Clin Chem 30: 196-199.
23. Van Coevorden A, Laurent E, Decoster C, et al, 1989 Decreased basal and stimulated thyroropin secretion in healthy elderly men. J Clin Endocrinol Metab 69:177-185.
24. Barreca T, Franceschini R, Messina V, et al, 1983 24-hour thyroid-stimulating hormone secretory pattern in elderly men. Gerontology 31: 119-123.
25. Van den Beld AW, Visser TJ, Feelders RA, et al, 2005 Thyroid hormone concentrations, disease, physical function, and mortality in elderly men. J Clin Endocrinol Metab 90:6403-6409.
26. Mariotti S, Barbesino B, Caturegli P, et al, 1993 Complex alteration of thyroid function in healthy centenarians. J Clin Endocrinol Metab 77: 1130-1134.
27. Atzmon G, Barzilai N, Hollowell JG, et al, 2009 Extreme longevity is associated with increased serum thyrotropin. J Clin Endocrinol Metab 94: 1251-1254.
28. Longcope C 1986 Adrenal and gonadal androgen secretion in normal females. Clin Endocrinol Metab 15:213-228.
29. Sulcova J, Hill M, Hampl R, Starka L 1997 Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects. J Endocrinol 54: 57-62.
30. Nafziger AN, Bowlin ST, Jenkins PL, et al, 1998 Longitudinal changes in dehydroepiandrosterone concentrations in men and women. J Lab Clin Med 131: 316-323.
31. Salvini S, Stampfer MJ, Barbieri RL, Hennekens CH, 1992 Effects of age, smoking and vitamins on plasma DHEA-S levels: A cross-sectional study in men. J Clin Endocrinol Metab 74: 139-143.
32. Orentreich N, Brind JL, Vogelman JH, Andres R, Baldwin H, 1992 Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men. J Clin Endocrinol Metab 75: 1002-1004.
33. Ravaglia G, Forti P, Maioli F, et al, 1996 The relationship of dehydroepiadrosterone sulfate (DHEA-S) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds. J Clin Endocrinol Metab 3: 1173-1178.
34. Cumming DC, Rebar RW, Hopper BR, Yen SSC, 1982 Evidence for an influence of the ovary on circulating dehydroepiandrosterone sulfate levels. J Clin Endocrinol Metab 54: 1069.
35. Veldhuis JD, 1999 Recent insights into neuroendocrine mechanisms of aging of the human male hypothalamicpituitary-gonadal axis. J Andrology 20: 1-17.
36. Morley JE, Kaiser FE, Perry II HM, et al, 1987 Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 46: 410-413.
37. Vermeulen A, Kaufman JM, Giagulli VA, 1996 Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 81: 1821-1826.
38. Kaufman JM, Vermeulen A 1999 Androgens in male senescence. In Testosterone Action Deficiency Substitution Eds Nieschlag E, Behre HM, Springer Verlag Berlin, pp, 437-471.
39. Kaufman JM, Vermeulen A, 1997 Declining gonadal function in olderly men. Bailliere's Endocrinol Metab 11:2 89-309.
40. Ferrini RL, Barrett-Connor E, 1998 Sex hormones and age: A cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men. Am J Epidemiol 147: 750-754.
41. Harman SM, Metter EJ, Tobin JD, et al, 2001 Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 86: 724-731.
42. Barrett-Connor E, von Muhlen DG, Kritz-Silverstein D, 1999 Bioavailable testosterone and depressed mood in older men: The Rancho Bernardo Study. J Clin Endocrinol Metab 84: 573-577.
43. Zumoff B, Strain CW, Kream J, et al, 1982 Age variation of the 24-hour mean plasma concentrations of androgens, estrogens, and gonadotropins in normal adult men. J Clin Endocrinol Metab 54: 534-538.
44. Herman SM, Tsitouras PD, 1980 Reproductive hormones in aging men I. Measurement of sex steroids, basal luteinizing hormone and Leydig cell response to human chorionic gonadotropin. J Clin Endocrinol 51: 35-40.
45. Nankin HR, Lin T, Murono EP, Osterman J, 1981 The aging Leydig cell II, Gonadotropin stimulation in men. J Androl 2: 181-189.
46. Nieschlag E, Lammers U, Freischem CW, et al, 1982 Reproductive function in young fathers and grand fathers. J Clin Endocrinol Metab 55: 676-681.
47. Kaufman JM, Giri M, Deslypene GP, Thomas G, Vermulen A, 1991 Influence of age on the responsiveness of gonadotropins to luteinizing hormone releasing hormone in males. J Clin Endocrinol 57: 1255-1260.
48. Deslypere JP, Kaufman JM, Vermeulen J, et al, 1987 Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men. J Clin Endocrinol Metab 64: 68-74.
49. Mulligan T, Iranmanesh A, Georgious S, et al, 1995 Amplified nocturnal luteinizing hormone (LH) secretory burst sequency with selective attenuation of pulsatile (but not basal) testosterone secretion in healthy aging men: possible Leydig cell desensitization to endogenous LH signaling a clinical research center study. J Clin Endocrinol Metab 80: 3025-3031.
50. Urban RJ, Evans WS, Rogol AD, et al, 1998 Contemporary aspects of discrete peak detections algorithm I. The paradigm of the luteinizing hormone pulse signal in men. Endocrinol Rev 9: 3-37.
51. Bremmer WJ, Vitiello MV, Prinz PW, 1983 Loss of circadian rhythmcity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 56: 1278-1281.
52. Tenover JS, Matsumoto AM, Clifton DK, et al, 1998 Age related alteration in the circadian rhythm of pulsatile Luteinizing hormone and testosterone secretion in healthy men. J Gerontol 43: M163-169.
53. McEwan BS, 2001 Invited review. Estrogens effects on the brain: Multiple sites and molecular mechanisms. J Apl Physiol 91: 2785-2801.
54. Eustratiadou M, Tamvakopoulou E, Panitsa-Faflia CH, Batrinos M, 1975 Frequency of atrophic vaginal smears in 1000 postmenopausal women more than 50 years old. Minerva Medica Greca 3; 152-159. (in Greek)
55. Burger HG, Dudley EC, Cui J, Dennerstein L, Hopper JL, 2000 A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. J Clin Endocrinol Metab 85: 2832-2838.
56. Batrinos ML, Panitsa-Fafla CH, Pitoulis SP, et al, 1979 The clinical features of the menopause and its relation to the length of pregnancies and lactation. Maturitas 1: 261-268.
57. Atwood CS, Meethal SV, Liu T, et al, 2005 Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence. J Neuropathol Exp Neurol 64: 93-103.