Extreme Longevity is associated with increased serum thyrotropin

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 4, 2009, Pages 1251-1254

  Atzmon, Gil ^a   Barzilai, Nir ^a   Hollowell, Joseph G ^b   Surks, Martin I ^a   Gabriely, Ilan ^a,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c Belfer Building ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYROTROPIN; THYROXINE;

AGED; AGING; ARTICLE; CONTROLLED STUDY; FEMALE; HEALTH SURVEY; HUMAN; JEW; LONGEVITY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

EID: 65249161844     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-2325     Document Type: Article

References (20)

1. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE 2002 Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87:489-499
2. Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT 2005 Consensus statement 1: subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society. Thyroid 15:24-28; response, 32-33
3. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, Franklyn JA, HershmanJM, BurmanKD, Denke MA, GormanC, Cooper RS, WeissmanNJ 2004 Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 291:228 -238
4. Biondi B, Cooper DS 2008 The clinical significance of subclinical thyroid dysfunction. Endocr Rev 29:76-131
5. Buffenstein R, Pinto M 15 July 2008 Endocrine function in naturally long- living small mammals. Mol Cell Endocrinol 299:101-111
6. Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frolich M, Westendorp RG 2004 Thyroid status, disability and cognitive function, and survival in old age. JAMA 292:2591-2599
7. Ravaglia G, Forti P, Maioli F, Nesi B, Pratelli L, Savarino L, Cucinotta D, Cavalli G 2000 Blood micronutrient and thyroid hormone concentrations in the oldest-old. J Clin Endocrinol Metab 85:2260 -2265
8. Barzilai N, AtzmonG, Schechter C, Schaefer EJ, Cupples AL, LiptonR, Cheng S, Shuldiner AR 2003 Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 290:2030 -2040
9. BarzilaiN,GabrielyI,GabrielyM,IankowitzN,SorkinJD 2001 Offspring of centenarians have a favorable lipid profile. J Am Geriatr Soc 49:76-79
10. Surks MI, Hollowell JG 2007 Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metab 92:4575-4582
11. Boucai L, Surks MI 25 August 2008 Reference limits of serum thyrotropin (TSH) and free thyroxine (free T4) are significantly influenced by race and age in an urban outpatient practice of medicine. Clin Endocrinol (Oxf) 10.1111/j. 1365-2265.2008.03390.x
12. Mariotti S, Franceschi C, Cossarizza A, Pinchera A 1995 The aging thyroid. Endocr Rev 16:686 -715
13. Tietz NW, Shuey DF, Wekstein DR 1992 Laboratory values in fit aging individuals-sexagenarians through centenarians. Clin Chem 38:1167-1185
14. van den Beld AW, Visser TJ, Feelders RA, Grobbee DE, Lamberts SW 2005 Thyroid hormone concentrations, disease, physical function, and mortality in elderly men. J Clin Endocrinol Metab 90:6403-6409
15. Magri F, Muzzoni B, Cravello L, Fioravanti M, Busconi L, Camozzi D, Vignati G, Ferrari E 2002 Thyroid function in physiological aging and in centenarians: possible relationships with some nutritional markers. Metabolism 51:105-109
16. Bartke A, Brown-Borg H 2004 Life extension in the dwarf mouse. Curr Top Dev Biol 63:189-225
17. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A 1996 Dwarf mice and the ageing process. Nature 384:33
18. Ladenson PW 2008 Cardiovascular consequences of subclinical thyroid dysfunction: More smoke but no fire. Ann Intern Med 148:880 -881
19. Ochs N, Aur R, Bauer DC, Nanchen D, Gussekloo J, Cornuz J, Rodondi N 2008 Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality. Ann Intern Med 148:8321-8845
20. Razvi S, Shakoor A, Vanderpump M, Weaver JU, Pearce SHS 2008 The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis. J Clin Endocrinol Metab 93:2998 -3007