Vitex negundo inhibits cyclooxygenase-2 inflammatory cytokine-mediated inflammation on carrageenan-induced rat hind paw edema

Pharmacognosy Research

Volumn 4, Issue 3, 2012, Pages 134-137

  Chattopadhyay, Pronobesh ^a   Hazarika, Soilyadhar ^a   Dhiman, Sunil ^a   Upadhyay, Aadesh ^a   Pandey, Anurag ^a   Karmakar, Sanjeev ^a   Singh, Lokendra ^a  

^a Defence R D Organization   (India)

Author keywords

Anti inflammatory; cyclooxygenase 2 inhibitors; Vitex negundo

Indexed keywords

CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOKINE; DICLOFENAC DIETHYLAMINE; PARAFFIN; PLACEBO; PROSTAGLANDIN SYNTHASE INHIBITOR; SALICYLIC ACID METHYL ESTER; UNCLASSIFIED DRUG; VITEX NEGUNDO EXTRACT; VITEX NEGUNDO LEAF OIL;

AEROSOL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; APPARATUS; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CLEVENGER; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; DRUG INHIBITION; DRUG INJECTION VOLUME; DRUG MECHANISM; DRUG SCREENING; ENZYME IMMUNOASSAY; ENZYME INHIBITION; HINDLIMB; INFLAMMATION; MALE; MEDIATOR; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PAW EDEMA; PLANT LEAF; PLETHYSMOGRAPH; PLETHYSMOGRAPHY; PLETHYSMOMETER; RAT; SERUM; SIGNAL TRANSDUCTION; VITEX NEGUNDO;

EID: 84864834906     PISSN: None     EISSN: 09748490     Source Type: Journal    
DOI: 10.4103/0974-8490.99072     Document Type: Article

References (24)

1. Jabeen A, Khan M, Ahmad M, Zafar M, Ahmad F. Indigenous uses of economically important flora of Margallah Hills National Park Islamabad Pakistan. Afr J Biotech 1999;8:763-84.
2. Banerji A, Chadha MS, Malshet VG. Isolation of 5-hydroxy-36-73'4'- pentamethoxyflavone from Vitex negundo. Phytochemistry 1969;8:511-2.
3. Sehgal CK, Taneja SC, Dhar KL, Atal CK. '2'-p-hydroxybenzoyl mussaenosidic acid a new iridoid glucoside from Vitex negundo. Phytochemistry 1982;21:363-6.
4. Sehgal CK, Taneja SC, Dhar KL, Atal CK. '6'-p-hydroxybenzoyl mussaenosidic acid an iridoid glucoside from Vitex negundo. Phytochemistry 1983;22:1036-8.
5. Achari B, Chowdhuri US, Dutta PK, Pakrashi SC. Two isomeric flavones from Vitex negundo. Phytochemistry 1984;23:703-4.
6. Singh V, Dayal R, Bartley J. Volatile constituents of Vitex negundo leaves. Planta Med 1999;65:580-5.
7. Tiwari OP, Tripathi YB. Antioxidant properties of different fractions of Vitex negundo Linn. Food Chem 2007;100:1170-6. (Pubitemid 44062202)
8. Devi PR, Kumari SK, Kokilavani C. Effect of Vitex negundo leaf extract on the free radicals scavengers in complete Freund's adjuvant induced arthritic rats. Indian J Clin Biochem 2007;22:143-7. (Pubitemid 46411218)
9. Azhar-Ul-Haq, Malik A, Anis I, Khan SB, Ahmed E, Ahmed Z, et al. Enzyme inhibiting lignans from Vitex negundo. Chem Pharm Bull 2004;52:1269-72. (Pubitemid 41364441)
10. Lodhi A, Choudhary I, Malik A, Ahmad S. 'a-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn. J Enzyme Inhib Med Chem 2008;23:400-5. (Pubitemid 351935062)
11. Umamaheswari M, Asok Kumar K, Somasundaram A, Sivashanmugam T, Subhadradevi V, Ravi TK. Xanthine oxidase inhibitory activity of some Indian medical plants. J Ethnopharmacol 2007;109:547-51. (Pubitemid 46084843)
12. Azhar UH, Malik A, Khan MT, Khan SB, Anwar-Ul-Haq, Ahmad A, et al. Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and their structure-activity relationship. Phytomedicine 2006;13:255-60. (Pubitemid 43255325)
13. Tandon VR, Gupta RK. Anti-inflammatory activity and mechanism of action of Vitex negundo Linn. Int J Pharmacol 2006;2:303-8.
14. Gupta RK, Tandon VR. An experimental evaluation of anticonvulsant activity of Vitex negundo. Indian J Physiol Pharmacol 2005;49:163-72.
15. Leblanc Y, Roy P, Boyce S, Brideau C, Chan CC, Charleson S, et al. SAR in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor. Bioorg Med Chem Lett 1999;9:2207-12. (Pubitemid 29371937)
16. Tan-no K, Nakajima T, Shoji T, Nakagawasai O, Niijima F, Ishikawa M, et al. Anti-inflammatory effect of property through inhibition of nitric oxide production on carrageenan-induced mouse paw edema. Biol Pharm Bull 2006;29:96-9. (Pubitemid 43036702)
17. Oku H, Ishiguro K. Cyclooxygenase-2 inhibitory 14-naphthoquinones from Impatiens balsamina L. Biol Pharm Bull 2002;25:658-60. (Pubitemid 39663266)
18. Jocelyne G, Kevin B, Robert G, Joseph M, Denis R. Carrageenaninduced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 Synthase-1. J Biol Chem 2004;279:24866-75.
19. Xie WL, Chipman JG, Robertson DL, Erikson RL, Simmons DL. Expression of a mitogen-responsive gene encoding prostaglandin syntheses is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991;88:2692-6. (Pubitemid 21916484)
20. Feldman M, McMahon AT. Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional non-steroidal antiinflammatory drugs with less gastrointestinal toxicity? Ann Intern Med 2000;132:134-43. (Pubitemid 30044181)
21. Flower RJ. Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev 1974;26:33-67.
22. Hong CH, Hur SK, Oh OJ, Kim SS, Nam KA, Lee SK. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 2002;83:153-9. (Pubitemid 36164741)
23. Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, et al. Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 2001;410:471-5. (Pubitemid 32240046)
24. Yaksh TL, Dirig DM, Conway CM, Svensson C, Luo ZD, Isakson PC. The acute antihyperalgesic action of nonsteroidal, antiinflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. J Neurol Sci 2001;21:5847-53. (Pubitemid 32737717)