Down regulation of differentiated embryonic chondrocytes 1 (DEC1) is involved in 8-methoxypsoralen-induced apoptosis in HepG2 cells

Toxicology

Volumn 301, Issue 1-3, 2012, Pages 58-65

  Peng, Yan ^a   Liu, Wei ^a   Xiong, Jing ^a   Gui, Hai Yan ^a   Feng, Xue Min ^a   Chen, Rui Ni ^a   Hu, Gang ^a   Yang, Jian ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

8 Methoxypsoralen (8 MOP); Apoptosis; Differentiated embryonic chondrocyte gene 1 (DEC1)

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DIFFERENTIATED EMBRYONIC CHONDROCYTE 1; METHOXSALEN; PROCASPASE 3; PROCASPASE 8; PROCASPASE 9; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER THERAPY; CELL STRAIN HEPG2; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CASPASE 8; CASPASE 9; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HEP G2 CELLS; HOMEODOMAIN PROTEINS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; METHOXSALEN; PHOTOSENSITIZING AGENTS; TIME FACTORS;

EID: 84864816766     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.06.022     Document Type: Article

References (33)

1. Adam W., Mielke K., Saha-Moller C.R., Moller M., Stopper H., Hutterer R., Schneider F.W., Ballmaier D., Epe B., Gasparro F.F., Chen X., Kagan J. Photochemical and photobiological studies of a furonaphthopyranone as a benzo-spaced psoralen analog in cell-free and cellular DNA. Photochem. Photobiol. 1997, 66:46-54.
2. Altieri D.C. Validating survivin as a cancer therapeutic target. Nat. Rev. Cancer 2003, 3:46-54.
3. Arlett C.F., Heddle J.A., Broughton B.C., Rogers A.M. Cell killing and mutagenesis by 8-methoxypsoralen in mammalian (rodent) cells. Clin. Exp. Dermatol. 1980, 5:147-158.
4. Arroyo M.P., Tift L. Vitiligo therapy: where are we now?. J. Drugs Dermatol. 2003, 2:404-408.
5. Chakrabarti J., Turley H., Campo L., Han C., Harris A.L., Gatter K.C., Fox S.B. The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers. Br. J. Cancer 2004, 91:954-958.
6. Chau G.Y., Lee A.F., Tsay S.H., Ke Y.R., Kao H.L., Wong F.H., Tsou A.P., Chau Y.P. Clinicopathological significance of survivin expression in patients with hepatocellular carcinoma. Histopathology 2007, 51:204-218.
7. Ehata S., Hanyu A., Hayashi M., Aburatani H., Kato Y., Fujime M., Saitoh M., Miyazawa K., Imamura T., Miyazono K. Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1. Cancer Res. 2007, 67:9694-9703.
8. Giatromanolaki A., Koukourakis M.I., Sivridis E., Turley H., Wykoff C.C., Gatter K.C., Harris A.L. DEC1 (STRA13) protein expression relates to hypoxia-inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. J. Pathol. 2003, 200:222-228.
9. Hovest M.G., Bruggenolte N., Hosseini K.S., Krieg T., Herrmann G. Senescence of human fibroblasts after psoralen photoactivation is mediated by ATR kinase and persistent DNA damage foci at telomeres. Mol. Biol. Cell 2006, 17:1758-1767.
10. Ince N., Wands J.R. The increasing incidence of hepatocellular carcinoma. N. Engl. J. Med. 1999, 340:798-799.
11. Kon N., Hirota T., Kawamoto T., Kato Y., Tsubota T., Fukada Y. Activation of TGF-beta/activin signalling resets the circadian clock through rapid induction of DEC1 transcripts. Nat. Cell Biol. 2008, 10:1463-1469.
12. Kondo J., Sato F., Fujimoto K., Kusumi T., Imanaka T., Kawamoto T., Uk B., Noshiro M., Kato Y., Sato T., Kijima H. 57Arg in the bHLH transcription factor DEC2 is essential for the suppression of CLOCK/BMAL2-mediated transactivation. Int. J. Mol. Med. 2006, 17:1053-1056.
13. Lee Y.M., Wu T.H., Chen S.F., Chung J.G. Effect of 5-methoxypsoralen (5-MOP) on cell apoptosis and cell cycle in human hepatocellular carcinoma cell line. Toxicol. In Vitro 2003, 17:279-287.
14. Legitimo A., Consolini R., Failli A., Fabiano S., Bencivelli W., Scatena F., Mosca F. In vitro treatment of monocytes with 8-methoxypsolaren and ultraviolet A light induces dendritic cells with a tolerogenic phenotype. Clin. Exp. Immunol. 2007, 148:564-572.
15. Li Y., Xie M., Yang J., Yang D., Deng R., Wan Y., Yan B. The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. Oncogene 2006, 25:3296-3306.
16. Li Y., Zhang H., Xie M., Hu M., Ge S., Yang D., Wan Y., Yan B. Abundant expression of DEC1/Stra13/Sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation. Biochem. J. 2002, 367:413-422.
17. Liu Y., Sato F., Kawamoto T., Fujimoto K., Morohashi S., Akasaka H., Kondo J., Wu Y., Noshiro M., Kato Y., Kijima H. Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells. Genes Cells 2010, 15:315-325.
18. Martelli A.M., Cappellini A., Tazzari P.L., Billi A.M., Tassi C., Ricci F., Fala F., Conte R. Caspase-9 is the upstream caspase activated by 8-methoxypsoralen and ultraviolet-A radiation treatment of Jurkat T leukemia cells and normal T lymphocytes. Haematologica 2004, 89:471-479.
19. Miyazaki K., Kawamoto T., Tanimoto K., Nishiyama M., Honda H., Kato Y. Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. J. Biol. Chem. 2002, 277:47014-47021.
20. Nakashima A., Kawamoto T., Honda K.K., Ueshima T., Noshiro M., Iwata T., Fujimoto K., Kubo H., Honma S., Yorioka N., Kohno N., Kato Y. DEC1 modulates the circadian phase of clock gene expression. Mol. Cell. Biol. 2008, 28:4080-4092.
21. Nicholson D.W., Ali A., Thornberry N.A., Vaillancourt J.P., Ding C.K., Gallant M., Gareau Y., Griffin P.R., Labelle M., Lazebnik Y.A., Et A. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995, 376:37-43.
22. Palmer D.H. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 2008, 359:2498-2499.
23. Panno M.L., Giordano F., Palma M.G., Bartella V., Rago V., Maggiolini M., Sisci D., Lanzino M., De Amicis F., Ando S. Evidence that bergapten, independently of its photoactivation, enhances p53 gene expression and induces apoptosis in human breast cancer cells. Curr. Cancer Drug Targets 2009, 9:469-481.
24. Patel T., Gores G.J., Kaufmann S.H. The role of proteases during apoptosis. FASEB J. 1996, 10:587-597.
25. Sato F., Bhawal U.K., Kawamoto T., Fujimoto K., Imaizumi T., Imanaka T., Kondo J., Koyanagi S., Noshiro M., Yoshida H., Kusumi T., Kato Y., Kijima H. Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression. Genes Cells 2008, 13:131-144.
26. Sato F., Kawamoto T., Fujimoto K., Noshiro M., Honda K.K., Honma S., Honma K., Kato Y. Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur. J. Biochem. 2004, 271:4409-4419.
27. Sun S.Y., Yue P., Wu G.S., El-Deiry W.S., Shroot B., Hong W.K., Lotan R. Implication of p53 in growth arrest and apoptosis induced by the synthetic retinoid CD437 in human lung cancer cells. Cancer Res. 1999, 59:2829-2833.
28. Thin T.H., Li L., Chung T.K., Sun H., Taneja R. Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis. EMBO Rep. 2007, 8:401-407.
29. Wackernagel A., Hofer A., Legat F., Kerl H., Wolf P. Efficacy of 8-methoxypsoralen vs. 5-methoxypsoralen plus ultraviolet A therapy in patients with mycosis fungoides. Br. J. Dermatol. 2006, 154:519-523.
30. Ward D.M. Extracorporeal photopheresis: how, when, and why. J. Clin. Apheresis 2011, 26:276-285.
31. Yamada K., Kawata H., Shou Z., Mizutani T., Noguchi T., Miyamoto K. Insulin induces the expression of the SHARP-2/Stra13/DEC1 gene via a phosphoinositide 3-kinase pathway. J. Biol. Chem. 2003, 278:30719-30724.
32. Yang X.O., Angkasekwinai P., Zhu J., Peng J., Liu Z., Nurieva R., Liu X., Chung Y., Chang S.H., Sun B., Dong C. Requirement for the basic helix-loop-helix transcription factor DEC2 in initial TH2 lineage commitment. Nat. Immunol. 2009, 10:1260-1266.
33. Zhu Z.B., Chen Y., Makhija S.K., Lu B., Wang M., Rivera A.A., Yamamoto M., Wang S., Siegal G.P., Curiel D.T., McDonald J.M. Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinoma. Int. J. Oncol. 2006, 29:1319-1329.