Development of a pharmaceutical hepatotoxicity biomarker panel using a discovery to targeted proteomics approach

Molecular and Cellular Proteomics

Volumn 11, Issue 8, 2012, Pages 394-410

  Collins, Ben C ^a,e   Miller, Christine A ^b   Sposny, Alexandra ^c   Hewitt, Phillip ^c   Wells, Martin ^d   Gallagher, William M ^a   Pennington, Stephen R ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b AGILENT TECHNOLOGIES   (United States)

^c Merck Serono GmbH   (Germany)

^d Nonlinear Dynamics   (United Kingdom)

^e ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATION EXCHANGE; CELL LYSATE; CONTROLLED STUDY; FRACTIONATION; GEL ELECTROPHORESIS; LIQUID CHROMATOGRAPHY; LIVER; LIVER INJURY; LIVER TOXICITY; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; RAT;

AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ANIMALS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; GENE EXPRESSION PROFILING; LIVER; MOLECULAR SEQUENCE DATA; NITRO COMPOUNDS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDES; PHENYL ETHERS; PPAR ALPHA; PROTEOME; PROTEOMICS; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

ANIMALIA; RATTUS;

EID: 84864810275     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M111.016493     Document Type: Article

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