Autotaxin in liver fibrosis

Clinica Chimica Acta

Volumn 413, Issue 23-24, 2012, Pages 1817-1821

  Ikeda, Hitoshi ^a   Yatomi, Yutaka ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Autotaxin; Liver fibrosis; Lysophosphatidic acid; Lysophospholipase D

Indexed keywords

AUTOTAXIN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; PHARMACOLOGICAL BIOMARKER; PHOSPHOLIPASE D; ALKYLGLYCEROPHOSPHOETHANOLAMINE PHOSPHODIESTERASE; LYSOPHOSPHOLIPID; PHOSPHODIESTERASE;

APOPTOSIS; CELL PROLIFERATION; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME SYNTHESIS; HEPATIC STELLATE CELL; HUMAN; HYDROLYSIS; IN VIVO STUDY; LIVER CELL CARCINOMA; LIVER FIBROSIS; NONHUMAN; PRIORITY JOURNAL; PRURITUS; REVIEW; BIOSYNTHESIS; BLOOD; ENZYMOLOGY; LIVER CIRRHOSIS; METABOLISM; PATHOLOGY; STELLATE CELL;

CARCINOMA, HEPATOCELLULAR; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; LYSOPHOSPHOLIPIDS; PHOSPHORIC DIESTER HYDROLASES; PRURITUS;

EID: 84864803143     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2012.07.014     Document Type: Review

References (56)

1. Moolenaar, W.H., Lysophospholipids in the limelight: autotaxin takes center stage. J Cell Biol 158 (2002), 197–199.
2. Moolenaar, W.H., van Meeteren, L.A., Giepmans, B.N., The ins and outs of lysophosphatidic acid signaling. Bioessays 26 (2004), 870–881.
3. Kishimoto, T., Matsuoka, T., Imamura, S., Mizuno, K., A novel colorimetric assay for the determination of lysophosphatidic acid in plasma using an enzymatic cycling method. Clin Chim Acta 333 (2003), 59–67.
4. Aoki, J., Taira, A., Takanezawa, Y., et al. Serum lysophosphatidic acid is produced through diverse phospholipase pathways. J Biol Chem 277 (2002), 48737–48744.
5. Stracke, M.L., Krutzsch, H.C., Unsworth, E.J., et al. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J Biol Chem 267 (1992), 2524–2529.
6. Stracke, M.L., Clair, T., Liotta, L.A., Autotaxin, tumor motility-stimulating exophosphodiesterase. Adv Enzyme Regul 37 (1997), 135–144.
7. Tokumura, A., Majima, E., Kariya, Y., et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem 277 (2002), 39436–39442.
8. Umezu-Goto, M., Kishi, Y., Taira, A., et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol 158 (2002), 227–233.
9. Tanaka, M., Okudaira, S., Kishi, Y., et al. Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J Biol Chem 281 (2006), 25822–25830.
10. van Meeteren, L.A., Ruurs, P., Stortelers, C., et al. Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol 26 (2006), 5015–5022.
11. Watanabe, N., Ikeda, H., Nakamura, K., et al. Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C. J Clin Gastroenterol 41 (2007), 616–623.
12. Watanabe, N., Ikeda, H., Nakamura, K., et al. Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity. Life Sci 81 (2007), 1009–1015.
13. Rockey, D.C., Housset, C.N., Friedman, S.L., Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. J Clin Invest 92 (1993), 1795–1804.
14. Ikeda, K., Wakahara, T., Wang, Y.Q., Kadoya, H., Kawada, N., Kaneda, K., In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation. Hepatology 29 (1999), 1760–1767.
15. Friedman, S.L., Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275 (2000), 2247–2250.
16. Abdel-Aziz, G., Lebeau, G., Rescan, P.Y., et al. Reversibility of hepatic fibrosis in experimentally induced cholestasis in rat. Am J Pathol 137 (1990), 1333–1342.
17. Shiratori, Y., Imazeki, F., Moriyama, M., et al. Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med 132 (2000), 517–524.
18. Iredale, J.P., Benyon, R.C., Pickering, J., et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 102 (1998), 538–549.
19. Issa, R., Williams, E., Trim, N., et al. Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut 48 (2001), 548–557.
20. Wright, M.C., Issa, R., Smart, D.E., et al. Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. Gastroenterology 121 (2001), 685–698.
21. Ikeda, H., Yatomi, Y., Yanase, M., et al. Effects of lysophosphatidic acid on proliferation of stellate cells and hepatocytes in culture. Biochem Biophys Res Commun 248 (1998), 436–440.
22. Yanase, M., Ikeda, H., Matsui, A., et al. Lysophosphatidic acid enhances collagen gel contraction by hepatic stellate cells: association with rho-kinase. Biochem Biophys Res Commun 277 (2000), 72–78.
23. Yanase, M., Ikeda, H., Ogata, I., et al. Functional diversity between Rho-kinase- and MLCK-mediated cytoskeletal actions in a myofibroblast-like hepatic stellate cell line. Biochem Biophys Res Commun 305 (2003), 223–228.
24. Ikeda, H., Nagashima, K., Yanase, M., et al. Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol, 2003, G880–G886.
25. Choi, J.W., Lee, C.W., Chun, J., Biological roles of lysophospholipid receptors revealed by genetic null mice: an update. Biochim Biophys Acta 1781 (2008), 531–539.
26. Choi, J.W., Herr, D.R., Noguchi, K., et al. LPA receptors: subtypes and biological actions. Annu Rev Pharmacol Toxicol 50 (2010), 157–186.
27. Tager, A.M., LaCamera, P., Shea, B.S., et al. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med 14 (2008), 45–54.
28. Jansen, S., Andries, M., Vekemans, K., Vanbilloen, H., Verbruggen, A., Bollen, M., Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells. Cancer Lett 284 (2009), 216–221.
29. Muro, H., Shirasawa, H., Kosugi, I., Nakamura, S., Defect of Fc receptors and phenotypical changes in sinusoidal endothelial cells in human liver cirrhosis. Am J Pathol 143 (1993), 105–120.
30. Ueno, T., Inuzuka, S., Torimura, T., et al. Serum hyaluronate reflects hepatic sinusoidal capillarization. Gastroenterology 105 (1993), 475–481.
31. Manning, D.S., Afdhal, N.H., Diagnosis and quantitation of fibrosis. Gastroenterology 134 (2008), 1670–1681.
32. Nakamura, K., Ohkawa, R., Okubo, S., et al. Measurement of lysophospholipase D/autotaxin activity in human serum samples. Clin Biochem 40 (2007), 274–277.
33. Baker, D.L., Morrison, P., Miller, B., et al. Plasma lysophosphatidic acid concentration and ovarian cancer. JAMA 287 (2002), 3081–3082.
34. Nakamura, K., Igarashi, K., Ide, K., et al. Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation. Clin Chim Acta 388 (2008), 51–58.
35. Nakagawa, H., Ikeda, H., Nakamura, K., et al. Autotaxin as a novel serum marker of liver fibrosis. Clin Chim Acta 412 (2011), 1201–1206.
36. Nakamura, K., Nangaku, M., Ohkawa, R., et al. Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome. Clin Chem Lab Med 46 (2008), 150–151.
37. Iwasawa, Y., Fujii, T., Nagamatsu, T., et al. Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta. Am J Reprod Immunol 62 (2009), 90–95.
38. Masuda, A., Fujii, T., Iwasawa, Y., et al. Serum autotaxin measurements in pregnant women: application for the differentiation of normal pregnancy and pregnancy-induced hypertension. Clin Chim Acta 412 (2011), 1944–1950.
39. Masuda, A., Nakamura, K., Izutsu, K., et al. Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma. Br J Haematol 143 (2008), 60–70.
40. Nakai, Y., Ikeda, H., Nakamura, K., et al. Specific increase in serum autotaxin activity in patients with pancreatic cancer. Clin Biochem 44 (2011), 576–581.
41. Kremer, A.E., Martens, J.J., Kulik, W., et al. Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology 139 (2010), 1008–1018 [1018 e1001].
42. Albers, H.M., Dong, A., van Meeteren, L.A., et al. Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc Natl Acad Sci U S A 107 (2010), 7257–7262.
43. Llovet, J.M., Burroughs, A., Bruix, J., Hepatocellular carcinoma. Lancet 362 (2003), 1907–1917.
44. Yoshioka, K., Matsumura, F., Akedo, H., Itoh, K., Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells. J Biol Chem 273 (1998), 5146–5154.
45. Genda, T., Sakamoto, M., Ichida, T., et al. Cell motility mediated by rho and Rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma. Hepatology 30 (1999), 1027–1036.
46. Ayaki, M., Mukai, M., Imamura, F., et al. Cooperation of fibronectin with lysophosphatidic acid induces motility and transcellular migration of rat ascites hepatoma cells. Biochim Biophys Acta 1495 (2000), 40–50.
47. Baumforth, K.R., Flavell, J.R., Reynolds, G.M., et al. Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells. Blood 106 (2005), 2138–2146.
48. Kishi, Y., Okudaira, S., Tanaka, M., et al. Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J Biol Chem 281 (2006), 17492–17500.
49. Hoelzinger, D.B., Mariani, L., Weis, J., et al. Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. Neoplasia 7 (2005), 7–16.
50. Yang, Y., Mou, L., Liu, N., Tsao, M.S., Autotaxin expression in non-small-cell lung cancer. Am J Respir Cell Mol Biol 21 (1999), 216–222.
51. Stassar, M.J., Devitt, G., Brosius, M., et al. Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization. Br J Cancer 85 (2001), 1372–1382.
52. Debies, M.T., Welch, D.R., Genetic basis of human breast cancer metastasis. J Mammary Gland Biol Neoplasia 6 (2001), 441–451.
53. Kehlen, A., Englert, N., Seifert, A., et al. Expression, regulation and function of autotaxin in thyroid carcinomas. Int J Cancer 109 (2004), 833–838.
54. Zhang, G., Zhao, Z., Xu, S., Ni, L., Wang, X., Expression of autotaxin mRNA in human hepatocellular carcinoma. Chin Med J (Engl) 112 (1999), 330–332.
55. Mazzocca, A., Dituri, F., Lupo, L., Quaranta, M., Antonaci, S., Giannelli, G., Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts. Hepatology 54 (2011), 920–930.
56. Ikeda, H., Enooku, K., Ohkawa, R., Koike, K., Yatomi, Y., Plasma lysophosphatidic acid levels and hepatocellular carcinoma. Hepatology, 2012 Jun 18 http://dx.doi.org/10.1002/hep.25886 [Epub ahead of print].