Transcriptional activity of paired homeobox Pax6 is enhanced by histone acetyltransferase Tip60 during mouse retina development

Biochemical and Biophysical Research Communications

Volumn 424, Issue 3, 2012, Pages 427-432

  Kim, Chul Hong ^a   Kim, Jung Woong ^a   Jang, Sang Min ^a   An, Joo Hee ^a   Song, Ki Hyun ^a   Choi, Kyung Hee ^a  

^a Chung Ang University   (South Korea)

Author keywords

Pax6; Protein protein interaction; Retinogenesis; Tip60; Transcriptional regulation

Indexed keywords

CELL DNA; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE TIP60; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; GENE INTERACTION; GENE TARGETING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RETINA DEVELOPMENT; TRANSCRIPTION INITIATION; ZINC FINGER MOTIF;

ANIMALS; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEK293 CELLS; HISTONE ACETYLTRANSFERASES; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, INBRED ICR; PAIRED BOX TRANSCRIPTION FACTORS; REPRESSOR PROTEINS; RETINA; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

ANIMALIA;

EID: 84864777036     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.126     Document Type: Article

References (35)

1. Halder G., Callaerts P., Gehring W.J. New perspectives on eye evolution. Curr. Opin. Genet. Dev. 1995, 5:602-609.
2. Chow R.L., Altmann C.R., Lang R.A., Hemmati-Brivanlou A. Pax6 induces ectopic eyes in a vertebrate. Development 1999, 126:4213-4222.
3. Davis-Silberman N., Kalich T., Oron-Karni V., Marquardt T., Kroeber M., Tamm E.R., Ashery-Padan R. Genetic dissection of Pax6 dosage requirements in the developing mouse eye. Hum. Mol. Genet. 2005, 14:2265-2276.
4. van Heyningen V., Williamson K.A. PAX6 in sensory development. Hum. Mol. Genet. 2002, 11:1161-1167.
5. Glaser T., Jepeal L., Edwards J.G., Young S.R., Favor J., Maas R.L. PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects. Nat. Genet. 1994, 7:463-471.
6. Tang H.K., Singh S., Saunders G.F. Dissection of the transactivation function of the transcription factor encoded by the eye developmental gene PAX6. J. Biol. Chem. 1998, 273:7210-7221.
7. Jun S., Desplan C. Cooperative interactions between paired domain and homeodomain. Development 1996, 122:2639-2650.
8. Jordan T., Hanson I., Zaletayev D., Hodgson S., Prosser J., Seawright A., Hastie N., van Heyningen V. The human PAX6 gene is mutated in two patients with aniridia. Nat. Genet. 1992, 1:328-332.
9. Azuma N., Nishina S., Yanagisawa H., Okuyama T., Yamada M. PAX6 missense mutation in isolated foveal hypoplasia. Nat. Genet. 1996, 13:141-142.
10. Mirzayans F., Pearce W.G., MacDonald I.M., Walter M.A. Mutation of the PAX6 gene in patients with autosomal dominant keratitis. Am. J. Hum. Genet. 1995, 57:539-548.
11. Azuma N., Hotta Y., Tanaka H., Yamada M. Missense mutations in the PAX6 gene in aniridia. Invest. Ophthalmol. Vis. Sci. 1998, 39:2524-2528.
12. Singh S., Chao L.Y., Mishra R., Davies J., Saunders G.F. Missense mutation at the C-terminus of PAX6 negatively modulates homeodomain function. Hum. Mol. Genet. 2001, 10:911-918.
13. Singh S., Tang H.K., Lee J.Y., Saunders G.F. Truncation mutations in the transactivation region of PAX6 result in dominant-negative mutants. J. Biol. Chem. 1998, 273:21531-21541.
14. Tzoulaki I., White I.M., Hanson I.M. PAX6 mutations: genotype-phenotype correlations. BMC Genet. 2005, 6:27.
15. Kamine J., Elangovan B., Subramanian T., Coleman D., Chinnadurai G. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 1996, 216:357-366.
16. Yang X.J. The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res. 2004, 32:959-976.
17. Sapountzi V., Logan I.R., Robson C.N. Cellular functions of TIP60. Int. J. Biochem. Cell Biol. 2006, 38:1496-1509.
18. Brady M.E., Ozanne D.M., Gaughan L., Waite I., Cook S., Neal D.E., Robson C.N. Tip60 is a nuclear hormone receptor coactivator. J. Biol. Chem. 1999, 274:17599-17604.
19. Cao X., Sudhof T.C. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 2001, 293:115-120.
20. Kim J.W., Jang S.M., Kim C.H., An J.H., Kang E.J., Choi K.H. Tip60 regulates myoblast differentiation by enhancing the transcriptional activity of MyoD via their physical interactions. FEBS J. 2011, 278:4394-4404.
21. Kim J.W., Jang S.M., Kim C.H., An J.H., Choi K.H. Transcriptional activity of neural retina leucine zipper (Nrl) is regulated by c-Jun N-terminal kinase and Tip60 during retina development. Mol. Cell. Biol. 2012, 32:1720-1732.
22. Tang Y., Luo J., Zhang W., Gu W. Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol. Cell 2006, 24:827-839.
23. Gavaravarapu S., Kamine J. Tip60 inhibits activation of CREB protein by protein kinase A. Biochem. Biophys. Res. Commun. 2000, 269:758-766.
24. Xiao H., Chung J., Kao H.Y., Yang Y.C. Tip60 is a co-repressor for STAT3. J. Biol. Chem. 2003, 278:11197-11204.
25. Hlubek F., Lohberg C., Meiler J., Jung A., Kirchner T., Brabletz T. Tip60 is a cell-type-specific transcriptional regulator. J. Biochem. 2001, 129:635-641.
26. Kim J.W., Song P.I., Jeong M.H., An J.H., Lee S.Y., Jang S.M., Song K.H., Armstrong C.A., Choi K.H. TIP60 represses transcriptional activity of p73beta via an MDM2-bridged ternary complex. J. Biol. Chem. 2008, 283:20077-20086.
27. Thomas T., Loveland K.L., Voss A.K. The genes coding for the MYST family histone acetyltransferases, Tip60 and Mof, are expressed at high levels during sperm development. Gene Expr. Patterns 2007, 7:657-665.
28. Young R.W. Cell differentiation in the retina of the mouse. Anat. Rec. 1985, 212:199-205.
29. Tuoc T.C., Stoykova A. Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. Genes Dev. 2008, 22:1972-1986.
30. Epstein J.A., Glaser T., Cai J., Jepeal L., Walton D.S., Maas R.L. Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing. Genes Dev. 1994, 8:2022-2034.
31. Kim E.A., Noh Y.T., Ryu M.J., Kim H.T., Lee S.E., Kim C.H., Lee C., Kim Y.H., Choi C.Y. Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2. J. Biol. Chem. 2006, 281:7489-7497.
32. Bopp D., Burri M., Baumgartner S., Frigerio G., Noll M. Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila. Cell 1986, 47:1033-1040.
33. Xu H.E., Rould M.A., Xu W., Epstein J.A., Maas R.L., Pabo C.O. Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes Dev. 1999, 13:1263-1275.
34. Wilson D.S., Guenther B., Desplan C., Kuriyan J. High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA. Cell 1995, 82:709-719.
35. Bruun J.A., Thomassen E.I., Kristiansen K., Tylden G., Holm T., Mikkola I., Bjorkoy G., Johansen T. The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions. Nucleic Acids Res. 2005, 33:2661-2675.