Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion development in apolipoprotein E-deficient mice

Atherosclerosis

Volumn 223, Issue 2, 2012, Pages 306-313

  Wei, Hao ^a   Zhang, Wei Jian ^a   McMillen, Timothy S ^b   LeBoeuf, Renee C ^b   Frei, Balz ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Atherosclerosis; Copper chelation; Endothelial activation; Tetrathiomolybdate; Vascular inflammation

Indexed keywords

APOLIPOPROTEIN E; CERULOPLASMIN; COPPER; CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; IRON; LOW DENSITY LIPOPROTEIN; MOLYBDENUM; MONOCYTE CHEMOTACTIC PROTEIN 1; TETRATHIOMOLYBDIC ACID; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; AORTA; ARTICLE; ATHEROSCLEROSIS; CERULOPLASMIN BLOOD LEVEL; CHELATION; CONTROLLED STUDY; DIET; DISEASE COURSE; GENE EXPRESSION; HEART; HOMEOSTASIS; IRON BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; STATISTICAL SIGNIFICANCE; VASCULITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AORTA; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CELL ADHESION MOLECULES; CERULOPLASMIN; CHELATING AGENTS; COPPER; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; INFLAMMATION; INFLAMMATION MEDIATORS; IRON; LIPIDS; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLYBDENUM; MYOCARDIUM;

EID: 84864771942     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.06.013     Document Type: Article

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