Intracellular metal ion chelators inhibit TNFα-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells

Free Radical Biology and Medicine

Volumn 34, Issue 6, 2003, Pages 674-682

  Zhang, Wei Jian ^a   Frei, Balz ^a  

^a OREGON STATE UNIVERSITY   (United States)

Author keywords

Atherosclerosis; Cell adhesion molecules; Endothelium; Metal ions; Signal transduction

Indexed keywords

2,9 DIMETHYL 1,10 PHENANTHROLINE; BATHOCUPROINEDISULFONIC ACID; CELL ADHESION MOLECULE; CHELATING AGENT; COPPER; CYCLOHEXIMIDE; CYTOKINE; DEFEROXAMINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON REGULATORY FACTOR 1; IRON; IRON CHELATING AGENT; MESSENGER RNA; METAL ION; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PYRROLIDINE DITHIOCARBAMATE; SULFONIC ACID DERIVATIVE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; TRANSITION ELEMENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; UPREGULATION; VASCULAR ENDOTHELIUM;

EID: 0037443807     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)01375-8     Document Type: Article

References (47)

1. Ross R. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340:1999;115-126.
2. Carlos T.M., Harlan J.M. Leukocyte-endothelial adhesion molecules. Blood. 84:1994;2068-2101.
3. Cybulsky M.I., Gimbrone M.A. Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 251:1991;788-791.
4. Van der Wal A.C., Das P.K., Tigges A.J., Becker A.E. Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions. Am. J. Pathol. 141:1992;1427-1433.
5. Cybulsky M.I., Iiyama K., Li H., Zhu S., Chen M., Iiyama M., Davis V., Gutierrez-Ramos J.C., Connelly P.W., Milstone D.S. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J. Clin. Invest. 107:2001;1255-1262.
6. Collins R.G., Velji R., Guevara N.V., Hicks M.J., Chan L., Beaudet A.L. P-selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J. Exp. Med. 191:2000;189-194.
7. Nageh M.F., Sandberg E.T., Marotti K.R., Lin A.H., Melchior E.P., Bullard D.C., Beaudet A.L. Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 17:1997;1517-1520.
8. Sullivan J.L. Iron and sex difference in heart disease risk. Lancet. 1:1981;1293-1294.
9. Salonen J.T., Nyyssonen K., Korpela H., Tuomilehto J., Seppanen R., Salonen R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation. 86:1992;803-811.
10. Kiechl S., Willeit J., Egger G., Poewe W., Oberhollenzer F. Body iron stores and the risk of carotid atherosclerosis prospective results from the Bruneck study . Circulation. 96:1997;3300-3307.
11. Pang J.H., Jiang M.J., Chen Y.L., Wang F.W., Wang D.L., Chu S.H., Chau L.Y. Increased ferritin gene expression in atherosclerotic lesions. J. Clin. Invest. 97:1996;2204-2212.
12. Araujo J.A., Romano E.L., Brito B.E., Parthe V., Romano M., Bracho M., Montano R.F., Cardier J. Iron overload augments the development of atherosclerotic lesions in rabbits. Arterioscler. Thromb. Vasc. Biol. 15:1995;1172-1180.
13. Lee T.S., Shiao M.S., Pan C.C., Chau L.Y. Iron-deficient diet reduces atherosclerotic lesions in apoE-deficient mice. Circulation. 99:1999;1222-1229.
14. Dabbagh A.J., Shwaery G.T., Keaney J.F. Jr., Frei B. Effect of iron overload and iron deficiency on atherosclerosis in the hypercholesterolemic rabbit. Arterioscler. Thromb. Vasc. Biol. 17:1997;2638-2645.
15. Kirk E.A., Heinecke J.W., LeBoeuf R.C. Iron overload diminishes atherosclerosis in apoE-deficient mice. J. Clin. Invest. 107:2001;1545-1553.
16. Martin A., Frei B. Both intracellular and extracellular vitamin C inhibit atherogenic modification of LDL by human vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 17:1997;1583-1590.
17. Leake D.S., Rankin S.M. The oxidative modification of low-density lipoproteins by macrophages. Biochem. J. 270:1990;741-748.
18. Heinecke J.W., Rosen H., Chait A. Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture. J. Clin. Invest. 74:1984;1890-1894.
19. Kok F.J., Van Duijn C.M., Hofman A., Van der Voet G.B., De Wolff F.A., Paays C.H., Valkenburg H.A. Serum copper and zinc and the risk of death from cancer and cardiovascular disease. Am. J. Epidemiol. 128:1988;352-359.
20. Salonen J.T., Salonen R., Korpela H., Suntioinen S., Tuomilehto J. Serum copper and the risk of acute myocardial infarction a prospective population study in men in eastern Finland . Am. J. Epidemiol. 134:1991;268-276.
21. Swain J., Gutteridge J.M. Prooxidant iron and copper, with ferroxidase and xanthine oxidase activities in human atherosclerotic material. FEBS Lett. 368:1995;513-515.
22. Ploplis V.A., Cornelissen I., Sandoval-Cooper M.J., Weeks L., Noria F.A., Castellino F.J. Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1. Am. J. Pathol. 158:2001;107-117.
23. Ferns G.A., Lamb D.J., Taylor A. The possible role of copper ions in atherogenesis the Blue Janus . Atherosclerosis. 133:1997;139-152.
24. Klaassen C.D. Heavy metals and heavy-metal antagonist. Gilman A.G., Goodman L.S., Gilman A. The pharmacological basis of therapeutics. 1985;1605-1627 Macmillan, New York.
25. de Mello Filho A.C., Meneghini R. Protection of mammalian cells by o-phenanthroline from lethal and DNA-damaging effects produced by active oxygen species. Biochim. Biophys. Acta. 847:1985;82-89.
26. Applebaum Y.J., Kuvin J., Borman J.B., Uretzky G., Chevion M. The protective role of neocuproine against cardiac damage in isolated perfused rat hearts. Free Radic. Biol. Med. 8:1990;133-143.
27. Collins T., Read M.A., Neish A.S., Whitley M.Z., Thanos D., Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules NF-kappa B and cytokine-inducible enhancers . FASEB J. 9:1995;899-909.
28. Neish A.S., Williams A.J., Palmer H.J., Whitley M.Z., Collins T. Functional analysis of the human vascular cell adhesion molecule 1 promoter. J. Exp. Med. 176:1992;1583-1593.
29. Neish A.S., Khachigian L.M., Park A., Baichwal V.R., Collins T. Sp1 is a component of the cytokine-inducible enhancer in the promoter of vascular cell adhesion molecule-1. J. Biol. Chem. 270:1995;28903-28909.
30. Zhang W.J., Frei B. Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells. FASEB J. 15:2001;2423-2432.
31. Zhang W.J., Wojta J., Binder B.R. Notoginsenoside R1 counteracts endotoxin-induced activation of endothelial cells in vitro and endotoxin-induced lethality in mice in vivo. Arterioscler. Thromb. Vasc. Biol. 17:1997;465-474.
32. Marui N., Offermann M.K., Swerlick R., Kunsch C., Rosen C.A., Ahmad M., Alexander R.W., Medford R.M. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J. Clin. Invest. 92:1993;1866-1874.
33. Halliwell B. Use of desferrioxamine as a 'probe' for iron-dependent formation of hydroxyl radicals. Evidence for a direct reaction between desferal and the superoxide radical. Biochem. Pharmacol. 34:1985;229-233.
34. De Caterina R., Libby P., Peng H.B., Thannickal V.J., Rajavashisth T.B., Gimbrone M.A. Jr., Shin W.S., Liao J.K. Nitric oxide decreases cytokine-induced endothelial activation. J. Clin. Invest. 96:1995;60-68.
35. Halliwell B., Gutteridge J.M.C. Role of free radicals and catalytic metal ions in human disease an overview . Methods Enzymol. 186:1990;1-85.
36. Morel D.W., DiCorleto P.E., Chisolm G.M. Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation. Arteriosclerosis. 4:1984;357-364.
37. Bolli R., Jeroudi M.O., Patel P.S., Aruoma O.I., Halliwell B., Lai E.K., McCay P.B. Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion evidence that myocardial 'stunning' is a manifestation of reperfusion injury . Circ. Res. 65:1989;607-622.
38. Sellke F.W., Shafique T., Ely D.L., Weintraub R.M. Coronary endothelial injury after cardiopulmonary bypass and ischemic cardioplegia is mediated by oxygen-derived free radicals. Circulation. 88:1993;II395-II400.
39. Duffy S.J., Biegelsen E.S., Holbrook M., Russell J.D., Gokce N., Keaney J.F. Jr., Vita J.A. Iron chelation improves endothelial function in patients with coronary artery disease. Circulation. 103:2001;2799-2804.
40. Rae T.D., Schmidt P.J., Pufahl R.A., Culotta V.C., O'Halloran T.V. Undetectable intracellular free copper the requirement of a copper chaperone for superoxide dismutase . Science. 284:1999;805-808.
41. Barbouti A., Doulias P.T., Zhu B.Z., Frei B., Galaris D. Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage. Free Radic. Biol. Med. 31:2001;490-498.
42. Schreck R., Albermann K., Baeuerle P.A. Nuclear factor B an oxidative stress-responsive transcription factor of eukaryotic cells . Free Radic. Res. Commun. 17:1992;221-237.
43. 2 in NF-kappaB activation by either cytokine in both primary and transformed endothelial cells. J. Biol. Chem. 272:1997;25941-25950.
44. Faruqi R., de la Motte C., DiCorleto P.E. Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells. J. Clin. Invest. 94:1994;592-600.
45. Ahmad M., Theofanidis P., Medford R.M. Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha. J. Biol. Chem. 273:1998;4616-4621.
46. Tummala P.E., Chen X.L., Medford R.M. NF-kappa B independent suppression of endothelial vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 gene expression by inhibition of flavin binding proteins and superoxide production. J. Mol. Cell. Cardiol. 32:2000;1499-1508.
47. Lee Y.W., Kuhn H., Hennig B., Neish A.S., Toborek M. IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells. J. Mol. Cell. Cardiol. 33:2001;83-94.