Insights from free-energy calculations: Protein conformational equilibrium, driving forces, and ligand-binding modes

Biophysical Journal

Volumn 103, Issue 2, 2012, Pages 342-351

  Huang, Yu Ming M ^a   Chen, Wei ^b   Potter, Michael J ^b   Chang, Chia En A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Verachem   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; IMIDAZOLE DERIVATIVE; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 14; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS;

AMINO ACID SEQUENCE; HUMANS; IMIDAZOLES; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 14; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIDINES; THERMODYNAMICS;

EID: 84864757178     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2012.05.046     Document Type: Article

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