Inhibition of secreted phospholipase A2 by proanthocyanidins: A comparative enzymological and in silico modeling study

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 30, 2012, Pages 7417-7420

  Lambert, Joshua D ^a   Yennawar, Neela ^b   Gu, Yeyi ^a   Elias, Ryan J ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

in silico modeling; inflammation; phospholipase A2; proanthocyanidin

Indexed keywords

ACTIVE SITE; ARACHIDONIC ACIDS; HYDROPHOBIC TUNNEL; IN-SILICO; INFLAMMATION; INHIBITORY ACTIVITY; MODELING STUDIES; N-TERMINALS; PHOSPHOLIPASE A; PROANTHOCYANIDINS; STRUCTURAL BASIS; TETRAMERS; VAN DER WAALS INTERACTIONS;

PHOSPHOLIPIDS; VAN DER WAALS FORCES;

OLIGOMERS;

PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PROANTHOCYANIDIN;

ARTICLE; CHEMISTRY; COMPUTER SIMULATION; SECRETION (PROCESS); STRUCTURE ACTIVITY RELATION;

COMPUTER SIMULATION; PHOSPHOLIPASE A2 INHIBITORS; PHOSPHOLIPASES A2; PROANTHOCYANIDINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864755818     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf302308k     Document Type: Article

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