Structural insights into cholinesterases inhibition by harmane β-carbolinium derivatives: A kinetics - Molecular modeling approach

Phytochemistry

Volumn 81, Issue , 2012, Pages 24-30

  Torres, Juliana M ^a   Lira, Aline F ^a   Silva, Daniel R ^a   Guzzo, Lucas M ^a   Sant'Anna, Carlos M R ^a   Kümmerle, Arthur E ^a   Rumjanek, Victor M ^a  

^a FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Carbolines; Cholinesterase kinetics; Harmane

Indexed keywords

ACETYLCHOLINE; CARBOLINE DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DRUG DERIVATIVE; HARMAN; HARMINE;

ARTICLE; CHEMICAL MODEL; CHEMISTRY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; IC 50; KINETICS; MOLECULAR DYNAMICS; PROTEIN ANALYSIS; RUBIACEAE; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINE; CARBOLINES; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; ENZYME ACTIVATION; HARMINE; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; MOLECULAR DYNAMICS SIMULATION; PROTEIN INTERACTION MAPPING; RUBIACEAE; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84864739607     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phytochem.2012.05.004     Document Type: Article

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