Beta3 adrenoceptors substitute the role of M 2 muscarinic receptor in coping with cold stress in the heart: Evidence from M 2KO mice

Cellular and Molecular Neurobiology

Volumn 32, Issue 5, 2012, Pages 859-869

  Benes, Jan ^a   Novakova, Martina ^a   Rotkova, Jana ^b   Farar, Vladimir ^a,b   Kvetnansky, Richard ^c   Riljak, Vladimir ^a,b   Myslivecek, Jaromir ^a,b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b TECHNICAL UNIVERSITY OF LIBEREC   (Czech Republic)

^c INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

Author keywords

Adenylyl cyclase; Beta adrenoceptors; Cold stress; Heart; Muscarinic receptors; Nitric oxide synthase

Indexed keywords

ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; MUSCARINIC M2 RECEPTOR; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CARDIOVASCULAR RESPONSE; COLD STRESS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; GENE EXPRESSION; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; HEART STRESS; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RECEPTOR BINDING;

ADAPTATION, PHYSIOLOGICAL; ADENYLATE CYCLASE; ANIMALS; BINDING SITES; CATECHOLAMINES; COLD TEMPERATURE; GENE EXPRESSION REGULATION; HEART; HEART VENTRICLES; MICE; NITRIC OXIDE SYNTHASE; PROTEIN BINDING; RECEPTOR, MUSCARINIC M2; RECEPTORS, ADRENERGIC, BETA-3; STRESS, PHYSIOLOGICAL;

ANIMALIA; MUS;

EID: 84864718022     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-011-9781-3     Document Type: Article

References (39)

1. Baker JG (2005) Evidence for a secondary state of the human {beta}3-adrenoceptor. Mol Pharmacol 68:1645-1655 (Pubitemid 41654348)
2. Brodde OE, Bruck H, Leineweber K (2006) Cardiac adrenoceptors: physiological and pathophysiological relevance. J Pharmacol Sci 100:323-337 (Pubitemid 44609527)
3. Chamberlain PD, Jennings KH, Paul F, Cordell J, Berry A, Holmes SD, Park J, Chambers J, Sennitt MV, Stock MJ, Cawthorne MA, Young PW, Murphy GJ (1999) The tissue distribution of the human beta3-adrenoceptor studied using a monoclonal antibody: direct evidence of the beta3-adrenoceptor in human adipose tissue, atrium and skeletal muscle. Int J Obes Relat Metab Disord 23:1057-1065 (Pubitemid 29476208)
4. Chesley A, Lundberg MS, Asai T, Xiao RP, Ohtani S, Lakatta EG, Crow MT (2000) The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3′-kinase. Circ Res 87:1172-1179
5. Communal C, Singh K, Sawyer DB, Colucci WS (1999) Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein. Circulation 100:2210-2212
6. De Matteis R, Arch JR, Petroni ML, Ferrari D, Cinti S, Stock MJ (2002) Immunohistochemical identification of the beta(3)-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine. Int J Obes Relat Metab Disord 26:1442-1450 (Pubitemid 36005774)
7. Fisher JT, Vincent SG, Gomeza J, Yamada M, Wess J (2004) Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J 18:711-713
8. Gauthier CLV, Kobzik L, Trochu JN, Khandoudi N, Bril A, Balligand JL, Le Marec H (1998) The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. J Clin Invest 1998:1377-1384 (Pubitemid 28467566)
9. Gauthier C, Tavernier G, Trochu JN, Leblais V, Laurent K, Langin D, Escande D, Le Marec H (1999) Interspecies differences in the cardiac negative inotropic effects of beta(3)-adrenoceptor agonists. J Pharmacol Exp Ther 290:687-693 (Pubitemid 29344563)
10. Gauthier C, Langin D, Balligand J-L (2000) b3-adrenoceptors in the cardiovascular system. Trends Pharmacol Sci 21:426-431
11. Gomeza J, Shannon H, Kostenis E, Felder C, Zhang L, Brodkin J, Grinberg A, Sheng H, Wess J (1999) Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci USA 96:1692-1697 (Pubitemid 29098513)
12. Gomeza J, Zhang L, Kostenis E, Felder CC, Bymaster FP, Brodkin J, Shannon H, Xia B, Duttaroy A, Deng CX, Wess J (2001) Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice. Life Sci 68:2457-2466 (Pubitemid 32455682)
13. Hamilton BS, Doods HN (2008) Identification of potent agonists acting at an endogenous atypical [beta]3-adrenoceptor state that modulate lipolysis in rodent fat cells. Eur J Pharmacol 580: 55-62
14. Hoffert JD, Chou CL, Fenton RA, Knepper MA (2005) Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct. J Biol Chem 280:13624-13630 (Pubitemid 40517256)
15. Krizanova O, Myslivecek J, Tillinger A, Jurkovicova D, Kubovcakova L (2007) Adrenergic and calcium modulation of the heart in stress: from molecular biology to function. Stress (Amsterdam, Netherlands) 10:173-184 (Pubitemid 46789473)
16. Lands AM, Arnold A, McAuliff JP, Luduena FP, Brown TG Jr (1967) Differentiation of receptor systems activated by sympathomimetic amines. Nature 214:597-598
17. Lee NH, Fraser CM (1993) Cross-talk between m1 muscarinic acetylcholine and beta 2-adrenergic receptors. cAMP and the third intracellular loop of m1 muscarinic receptors confer heterologous regulation. J Biol Chem 268:7949-7957 (Pubitemid 23120375)
18. Li H, Liu Y, Huang H, Tang Y, Yang B, Huang C (2010) Activation of beta3-adrenergic receptor inhibits ventricular arrhythmia in heart failure through calcium handling. Tohoku J Exp Med 222:167-174
19. Moens AL, Yang R, Watts VL, Barouch LA (2010) Beta 3-adrenoreceptor regulation of nitric oxide in the cardiovascular system. J Mol Cell Cardiol 48:1088-1095
20. Moniotte S, Kobzik L, Feron O, Trochu JN, Gauthier C, Balligand JL (2001) Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium. Circulation 103:1649-1655 (Pubitemid 32246612)
21. Moscona-Amir E, Henis YI, Sokolovsky M (1988) Guanosine 5′-triphosphate binding protein (Gi) and two additional pertussis toxin substrates associated with muscarinic receptors in rat heart myocytes: characterization and age dependency. Biochemistry 27:4985-4991
22. Muzzin P, Boss O, Mathis N, Revelli JP, Giacobino JP, Willcocks K, Badman GT, Cantello BC, Hindley RM, Cawthorne MA (1994) Characterization of a new, highly specific, beta 3-adrenergic receptor radioligand, [3H]SB 206606. Mol Pharmacol 46: 357-363 (Pubitemid 24271433)
23. Myslivecek J, Trojan S, Tucek S (1996) Biphasic changes in the density of muscarinic and beta-adrenergic receptors in cardiac atria of rats treated with diisopropylfluorophosphate. Life Sci 58:2423-2430 (Pubitemid 26198116)
24. Myslivecek J, Lisa V, Trojan S, Tucek S (1998) Heterologous regulation of muscarinic and beta-adrenergic receptors in rat cardiomyocytes in culture. Life Sci 63:1169-1182 (Pubitemid 29369122)
25. Myslivecek J, Ricny J, Palkovits M, Kvetnansky R (2004) The effects of short-term immobilization stress on muscarinic receptors, beta-adrenoceptors, and adenylyl cyclase in different heart regions. Ann N Y Acad Sci 1018:315-322 (Pubitemid 38951422)
26. Myslivecek J, Novakova M, Palkovits M, Krizanova O, Kvetnansky R (2006) Distribution of mRNA and binding sites of adrenoceptors and muscarinic receptors in the rat heart. Life Sci 79: 112-120 (Pubitemid 43737063)
27. Myslivecek J, Duysen EG, Lockridge O (2007) Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice. Naunyn-Schmiedeberg's Arch Pharmacol 376:83-92
28. Myslivecek J, Tillinger A, Novakova M, Kvetňanský R (2008) Regulation of adrenoceptor and muscarinic receptor gene expression after single and repeated stress. Ann N Y Acad Sci 1148:367-376
29. Nantel F, Bonin H, Emorine LJ, Zilberfarb V, Strosberg AD, Bouvier M, Marullo S (1993) The human beta 3-adrenergic receptor is resistant to short term agonist-promoted desensitization. Mol Pharmacol 43:548-555 (Pubitemid 23112732)
30. Paraschos A, Karliner JS (1994) Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes. Naunyn-Schmiedeberg's Arch Pharmacol 350:267-276 (Pubitemid 24282903)
31. Schulz R, Rassaf T, Massion PB, Kelm M, Balligand JL (2005) Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis. Pharmacol Ther 108:225-256 (Pubitemid 41691866)
32. Tavernier G, Toumaniantz G, Erfanian M, Heymann MF, Laurent K, Langin D, Gauthier C (2003) beta3-Adrenergic stimulation produces a decrease of cardiac contractility ex vivo in mice overexpressing the human beta3-adrenergic receptor. Cardiovasc Res 59:288-296 (Pubitemid 37272023)
33. Tillinger A, Mysliveček J, Nováková M, Krizanova O, Kvetňanský R (2008) Gene Expression of Adrenoceptors in the Hearts of Cold-Acclimated Rats Exposed to a Novel Stressor. Ann N Y Acad Sci 1148:393-399
34. Wang H, Lu Y, Wang Z (2007) Function of cardiac M3 receptors. Auton Autacoid Pharmacol 27:1-11
35. Wess J, Duttaroy A, Zhang W, Gomeza J, Cui Y, Miyakawa T, Bymaster FP, McKinzie L, Felder CC, Lamping KG, Faraci FM, Deng C, Yamada M (2003) M1-M5 muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cholinergic system. Recept Channels 9:279-290 (Pubitemid 37069448)
36. Wess J, Eglen RM, Gautam D (2007) Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev 6:721-733 (Pubitemid 47342315)
37. Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG (1999) Recent advances in cardiac beta(2)-adrenergic signal transduction. Circ Res 85:1092-1100
38. Xiao RP, Zhu W, Zheng M, Cao C, Zhang Y, Lakatta EG, Han Q (2006) Subtype-specific alpha1- and beta- adrenoceptor signaling in the heart. Trends Pharmacol Sci 27:330-337 (Pubitemid 43850004)
39. Zhao J, Su Y, Zhang Y, Pan Z, Yang L, Chen X, Liu Y, Lu Y, Du Z, Yang B (2010) Activation of cardiac muscarinic M3 receptors induces delayed cardioprotection by preserving phosphorylated connexin43 and up-regulating cyclooxygenase-2 expression. Br J Pharmacol 159:1217-1225