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Comparative analysis of chicken Hoxb-4 regulation in transgenic mice
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Morrison A, Chaudhuri C, Ariza-McNaughton L, Muchamore I, Kuroiwa A, Krumlauf R. Comparative analysis of chicken Hoxb-4 regulation in transgenic mice. Mech Dev. 53:1995;47-59.
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Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo
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Conlon, R.A.1
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Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells
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Simeone A, Acampora D, Nigro V, Faiella A, D'Esposisto M, Stornaiulo A, Mavilio F, Boncinelli E. Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells. Mech Dev. 33:1991;215-227.
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Mavilio, F.7
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7
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Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells
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Simeone A, Acampora D, Arcioni L, Andrews PW, Boncinelli E, Mavilio F. Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Nature. 346:1990;763-766.
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Simeone, A.1
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8
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0028150628
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Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1
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Studer M, Popperl H, Marshall H, Kuroiwa A, Krumlauf R. Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1. Science. 265:1994;1728-1732.
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Studer, M.1
Popperl, H.2
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0028419153
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The retinoid signalling pathway: Molecular and genetic analysis
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Chambon P. The retinoid signalling pathway: molecular and genetic analysis. Semin Cell Biol. 5:1994;115-125.
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Chambon, P.1
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0028065238
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A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
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Marshall H, Studer M, Popperl H, Aparicio S, Kuroiwa A, Brenner S, Krumlauf R. A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1. Nature. 370:1994;567-571.
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Marshall, H.1
Studer, M.2
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Brenner, S.6
Krumlauf, R.7
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11
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0026794938
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Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6
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Langston AW, Gudas LJ. Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6. Mech Dev. 38:1992;217-228.
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Langston, A.W.1
Gudas, L.J.2
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12
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0028897837
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Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila
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of special interest. An exhaustive study, focusing in great detail on the regulatory elements of the Hoxa-1 and Hoxa-2 genes and which provides the first in vivo evidence for a direct role of retinoids in HoxA gene regulation and, in addition, describes an evolutionarily conserved enhancer element which functions in mouse and Drosophila.
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Frasch M, Chen X, Lufkin T. Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila. of special interest Development. 121:1995;957-974 An exhaustive study, focusing in great detail on the regulatory elements of the Hoxa-1 and Hoxa-2 genes and which provides the first in vivo evidence for a direct role of retinoids in HoxA gene regulation and, in addition, describes an evolutionarily conserved enhancer element which functions in mouse and Drosophila.
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(1995)
Development
, vol.121
, pp. 957-974
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Frasch, M.1
Chen, X.2
Lufkin, T.3
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13
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0027103903
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Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity
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Marshall H, Nonchev S, Sham MH, Muchamore I, Lumsden A, Krumlauf R. Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity. Nature. 360:1992;737-741.
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Nature
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Marshall, H.1
Nonchev, S.2
Sham, M.H.3
Muchamore, I.4
Lumsden, A.5
Krumlauf, R.6
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14
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0027536252
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The zinc finger gene Krox20 regulates HoxB2 (Hox-2.8) during hindbrain segmentation
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Sham MH, Vesque C, Nonchev S, Marshall H, Frain M, Gupta RD, Whiting J, Wilkinson D, Charnay P, Krumlauf R. The zinc finger gene Krox20 regulates HoxB2 (Hox-2.8) during hindbrain segmentation. Cell. 72:1993;183-196.
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Sham, M.H.1
Vesque, C.2
Nonchev, S.3
Marshall, H.4
Frain, M.5
Gupta, R.D.6
Whiting, J.7
Wilkinson, D.8
Charnay, P.9
Krumlauf, R.10
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15
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0026005506
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Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression
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Whiting J, Marshall H, Cook M, Krumlauf R, Rigby PWJ, Stott D, Alleman RK. Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes Dev. 5:1991;2048-2059.
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Whiting, J.1
Marshall, H.2
Cook, M.3
Krumlauf, R.4
Rigby, P.W.J.5
Stott, D.6
Alleman, R.K.7
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16
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13344278018
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Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20
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of outstanding interest. A very impressive genetic and biochemical analysis of the role of the zinc-finger gene Krox20 in the direct regulation of Hox genes. In this study, the authors identify binding sites for Krox20 in a Hoxa-2 enhancer that drives expression in r3 and r5. They demonstrate further that the Krox20 binding sites are critical for expression in the developing hindbrain where Knox20 is expressed normally and that misexpression of Krox20 in other regions of the CNS can activate transgene expression via this enhancer.
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Nonchev S, Vesque C, Maconochie M, Seitanidou T, Ariza-McNaughton L, Frain M, Marshall H, Sham MH, Krumlauf R, Charnay P. Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20. of outstanding interest Development. 122:1995;543-554 A very impressive genetic and biochemical analysis of the role of the zinc-finger gene Krox20 in the direct regulation of Hox genes. In this study, the authors identify binding sites for Krox20 in a Hoxa-2 enhancer that drives expression in r3 and r5. They demonstrate further that the Krox20 binding sites are critical for expression in the developing hindbrain where Knox20 is expressed normally and that misexpression of Krox20 in other regions of the CNS can activate transgene expression via this enhancer.
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(1995)
Development
, vol.122
, pp. 543-554
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Nonchev, S.1
Vesque, C.2
Maconochie, M.3
Seitanidou, T.4
Ariza-McNaughton, L.5
Frain, M.6
Marshall, H.7
Sham, M.H.8
Krumlauf, R.9
Charnay, P.10
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17
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0029055810
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Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
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of outstanding interest. This is truly a landmark paper, providing the first genetic evidence for an evolutionarily conserved role of the Pbx/exd family in Hox gene function. Here, the authors demonstrate in mice and Drosophila a conserved positive autoregulatory loop which is dependent on labial family members and that binding of Hoxb-1 protein in vitro to an enhancer which drives expression in r4 is dependent upon Pbxlexd.
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Pöpperl H, Bienz M, Studer M, Chan SK, Aparicio S, Brenner S, Mann RS, Krumlauf R. Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx. of outstanding interest Cell. 81:1995;1031-1042 This is truly a landmark paper, providing the first genetic evidence for an evolutionarily conserved role of the Pbx/exd family in Hox gene function. Here, the authors demonstrate in mice and Drosophila a conserved positive autoregulatory loop which is dependent on labial family members and that binding of Hoxb-1 protein in vitro to an enhancer which drives expression in r4 is dependent upon Pbxlexd.
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(1995)
Cell
, vol.81
, pp. 1031-1042
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Pöpperl, H.1
Bienz, M.2
Studer, M.3
Chan, S.K.4
Aparicio, S.5
Brenner, S.6
Mann, R.S.7
Krumlauf, R.8
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18
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0026066608
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PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1
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Monica K, Galili N, Nourse J, Saltman D, Clearly ML. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol. 11:1991;6149-6157.
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Mol Cell Biol
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Monica, K.1
Galili, N.2
Nourse, J.3
Saltman, D.4
Clearly, M.L.5
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19
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0027197205
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Dpbx, a new homeobox gene closely related to the human proto-oncogene pbx1 molecular structre and developmental expression
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Flegel WA, Singson AW, Margolis JS, Bang AG, Posakony JW, Murre C. Dpbx, a new homeobox gene closely related to the human proto-oncogene pbx1 molecular structre and developmental expression. Mech Dev. 41:1993;155-161.
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Flegel, W.A.1
Singson, A.W.2
Margolis, J.S.3
Bang, A.G.4
Posakony, J.W.5
Murre, C.6
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20
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0029118224
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The pentapeptide motif of Hox proteins is required for cooperative DNA binding with PBx1, physically contacts pbx1 and enhances DNA binding by Pbx1
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Knoepfler PS, Kamps MP. The pentapeptide motif of Hox proteins is required for cooperative DNA binding with PBx1, physically contacts pbx1 and enhances DNA binding by Pbx1. Mol Cell Biol. 15:1995;5811-5819.
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Mol Cell Biol
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Knoepfler, P.S.1
Kamps, M.P.2
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21
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0028089760
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Transformation properties of the e2a - Pbx1 chimeric oncoprotein: Fusion with e2a is essential, but the pbx1 homeodomain is dispensable
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Monica K, Lebrun DP, Dedera DA, Brown R, Cleary ML. Transformation properties of the e2a - pbx1 chimeric oncoprotein: fusion with e2a is essential, but the pbx1 homeodomain is dispensable. Mol Cell Biol. 14:1994;8304-8314.
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Monica, K.1
Lebrun, D.P.2
Dedera, D.A.3
Brown, R.4
Cleary, M.L.5
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22
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0029008293
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Cooprative interactions between HOX and PBX proteins mediated by a conserved peptide motif
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of special interest. An early, insightful, and detailed biochemical investigation of the interactions between Hox proteins and Pbx1. The authors demonstrate that PBX1A participates in cooperative DNA binding with Hoxa-1 and Hoxd-4 proteins but fails to interact cooperatively with other Hox proteins of the Abdominal-B class. They also map the critical Hox-interacting domain to the conserved pentapeptide motif YPWMK located amino-terminal to the homeodomain.
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Phelan ML, Rambaldi I, Featherstone MS. Cooprative interactions between HOX and PBX proteins mediated by a conserved peptide motif. of special interest Mol Cell Biol. 15:1995;3989-3997 An early, insightful, and detailed biochemical investigation of the interactions between Hox proteins and Pbx1. The authors demonstrate that PBX1A participates in cooperative DNA binding with Hoxa-1 and Hoxd-4 proteins but fails to interact cooperatively with other Hox proteins of the Abdominal-B class. They also map the critical Hox-interacting domain to the conserved pentapeptide motif YPWMK located amino-terminal to the homeodomain.
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(1995)
Mol Cell Biol
, vol.15
, pp. 3989-3997
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Phelan, M.L.1
Rambaldi, I.2
Featherstone, M.S.3
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23
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0029079663
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The hexapeptide LFPWMR in hoxb-8 is required for cooperative DNA binding with pbx1 and pbx2 proteins
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Neuteboom STC, Peltenburg LTC, Vandijk MA, Murre C. The hexapeptide LFPWMR in hoxb-8 is required for cooperative DNA binding with pbx1 and pbx2 proteins. Proc Natl Acad Sci USA. 92:1995;9166-9170.
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(1995)
Proc Natl Acad Sci USA
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, pp. 9166-9170
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Neuteboom, S.T.C.1
Peltenburg, L.T.C.2
Vandijk, M.A.3
Murre, C.4
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24
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0028169993
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Extradenticle raises the DNA binding specificity of homeotic selector gene products
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Vandijk MA, Murre C. extradenticle raises the DNA binding specificity of homeotic selector gene products. Cell. 78:1994;617-624.
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(1994)
Cell
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Vandijk, M.A.1
Murre, C.2
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25
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0029160039
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Hox gene products modulate the DNA binding activity of Pbx1 and Pbx2
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Vandijk MA, Peltenburg LTC, Murre C. Hox gene products modulate the DNA binding activity of Pbx1 and Pbx2. Mech Dev. 52:1995;99-108.
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Mech Dev
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Vandijk, M.A.1
Peltenburg, L.T.C.2
Murre, C.3
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26
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0027519720
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Extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
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Rauskolb C, Peifer M, Wieschaus E. extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1. Cell. 74:1993;1101-1112.
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Cell
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Rauskolb, C.1
Peifer, M.2
Wieschaus, E.3
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27
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0027966927
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The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein
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Chan SK, Jaffe L, Capovilla M, Botas J, Mann RS. The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell. 78:1994;603-615.
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(1994)
Cell
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Chan, S.K.1
Jaffe, L.2
Capovilla, M.3
Botas, J.4
Mann, R.S.5
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28
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0027410147
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Sequences 5' of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development
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Behringer RR, Crotty DA, Tennyson VM, Brinster RL, Palmiter RD, Wolgemuth DJ. Sequences 5' of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development. Development. 117:1993;823-833.
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Development
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Behringer, R.R.1
Crotty, D.A.2
Tennyson, V.M.3
Brinster, R.L.4
Palmiter, R.D.5
Wolgemuth, D.J.6
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29
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0025163609
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Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivitives of transgenic mice
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Kress C, Vogels R, DeGraaff W, Bonnerot C, Meijink F, Nicolas JF, Deschamps J. Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivitives of transgenic mice. Development. 109:1990;775-786.
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Development
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Kress, C.1
Vogels, R.2
DeGraaff, W.3
Bonnerot, C.4
Meijink, F.5
Nicolas, J.F.6
Deschamps, J.7
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30
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0027384351
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Two rhombomeres are altered in Hoxa-1 mutant mice
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Mark M, Lufkin T, Vonesch J, Ruberte E, Olivo J, Doll P, Gorry P, Lumsden A, Chambon P. Two rhombomeres are altered in Hoxa-1 mutant mice. Development. 119:1993;319-338.
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(1993)
Development
, vol.119
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Mark, M.1
Lufkin, T.2
Vonesch, J.3
Ruberte, E.4
Olivo, J.5
Doll, P.6
Gorry, P.7
Lumsden, A.8
Chambon, P.9
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31
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0027249799
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Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain
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Carpenter EM, Goddard JM, Chisaka O, Manley NR, Capecchi MR. Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development. 118:1993;1063-1075.
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Development
, vol.118
, pp. 1063-1075
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Carpenter, E.M.1
Goddard, J.M.2
Chisaka, O.3
Manley, N.R.4
Capecchi, M.R.5
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32
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0029154614
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Developmental roles of the retinoic acid receptors
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of special interest. This is a very comprehensive review on our current understanding of the genetic aspects of retinoid function as determined through gene targeting of the nuclear retinoic acid receptors and cellular retinoid-binding proteins.
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Lohnes D, Mark M, Mendelsohn C, Dolle P, Decimo D, Lemeur M, Dierich A, Gorry P, Chambon P. Developmental roles of the retinoic acid receptors. of special interest J Steroid Biochem Mol Biol. 53:1995;475-486 This is a very comprehensive review on our current understanding of the genetic aspects of retinoid function as determined through gene targeting of the nuclear retinoic acid receptors and cellular retinoid-binding proteins.
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(1995)
J Steroid Biochem Mol Biol
, vol.53
, pp. 475-486
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Lohnes, D.1
Mark, M.2
Mendelsohn, C.3
Dolle, P.4
Decimo, D.5
Lemeur, M.6
Dierich, A.7
Gorry, P.8
Chambon, P.9
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33
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0027231485
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Function of retinoic acid receptor gamma (RARγ) in the mouse
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Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P. Function of retinoic acid receptor gamma (RARγ) in the mouse. Cell. 73:1993;643-658.
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(1993)
Cell
, vol.73
, pp. 643-658
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Lohnes, D.1
Kastner, P.2
Dierich, A.3
Mark, M.4
LeMeur, M.5
Chambon, P.6
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34
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0028088752
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Function of the retinoic acid receptors (RARs) during development 1 Craniofacial and skeletal abnormalities in RAR double mutants
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Lohnes D, Mark M, Mendelsohn C, Dolle P, Dierich A, Gorry P, Gansmuller A, Chambon P. Function of the retinoic acid receptors (RARs) during development 1 Craniofacial and skeletal abnormalities in RAR double mutants. Development. 120:1994;2723-2748.
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(1994)
Development
, vol.120
, pp. 2723-2748
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Lohnes, D.1
Mark, M.2
Mendelsohn, C.3
Dolle, P.4
Dierich, A.5
Gorry, P.6
Gansmuller, A.7
Chambon, P.8
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35
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0027471014
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Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene
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Pöpperl H, Featherstone MS. Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene. Mol Cell Biol. 13:1993;257-265.
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(1993)
Mol Cell Biol
, vol.13
, pp. 257-265
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Pöpperl, H.1
Featherstone, M.S.2
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36
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0029045063
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Mutations in paralogous Hox genes result in overlapping homeotic transformations of the axial skeleton: Evidence for unique and redundant function
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Horan GSB, Kovacs EN, Behringer RR, Featherstone MS. Mutations in paralogous Hox genes result in overlapping homeotic transformations of the axial skeleton: evidence for unique and redundant function. Dev Biol. 169:1995;359-372.
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(1995)
Dev Biol
, vol.169
, pp. 359-372
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Horan, G.S.B.1
Kovacs, E.N.2
Behringer, R.R.3
Featherstone, M.S.4
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37
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0029143166
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Compound mutants for the paralogous Hoxa-4, Hoxb-4, and Hoxd-4 genes show more complete homeotic transformations and a dose-dependent increse in the number of vertebrae transformed
-
of outstanding interest. This is a very extensive and convincing analysis of the role of paralogous Hox genes in patterning of the paraxial mesoderm and underlines the overlapping role that Hox paralogues can play in directing morphogenesis of vertebral structures.
-
Horan GSB, Ramirez-Solis R, Featherstone MS, Wolgemuth DJ, Bradley A, Behringer RR. Compound mutants for the paralogous Hoxa-4, Hoxb-4, and Hoxd-4 genes show more complete homeotic transformations and a dose-dependent increse in the number of vertebrae transformed. of outstanding interest Genes Dev. 9:1995;1667-1677 This is a very extensive and convincing analysis of the role of paralogous Hox genes in patterning of the paraxial mesoderm and underlines the overlapping role that Hox paralogues can play in directing morphogenesis of vertebral structures.
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(1995)
Genes Dev
, vol.9
, pp. 1667-1677
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Horan, G.S.B.1
Ramirez-Solis, R.2
Featherstone, M.S.3
Wolgemuth, D.J.4
Bradley, A.5
Behringer, R.R.6
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39
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0028073019
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Function of the retinoic acid receptors (RARs), during development 2. Multiple abnormalities at various stages of organogenesis in RAR double mutants
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Mendelsohn C, Lohnes D, Decimo D, Lufkin T, Lemeur M, Cambon P, Mark M. Function of the retinoic acid receptors (RARs), during development 2. Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development. 120:1994;2749-2771.
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Development
, vol.120
, pp. 2749-2771
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Mendelsohn, C.1
Lohnes, D.2
Decimo, D.3
Lufkin, T.4
Lemeur, M.5
Cambon, P.6
Mark, M.7
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40
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0026599290
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Developmental defects of the ear cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6.
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Chisaka O, Musci TS, Capecchi MR. Developmental defects of the ear cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6. Nature. 355:1992;516-520.
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(1992)
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50
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Regulation of the Hox-8 gene: Synergism between multimerized cis-acting elements increases responsiveness to positional information
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of special interest. A very detailed and well presented study on the elements which direct Hoxb-8 expression. Here, the authors exactingly dissect primarily the 5' flanking region of Hoxb-8 and reveal that several cis-acting elements interact cooperatively to set the normal Hoxb-8 expression domain. Each of the cis-acting elements can function alone but their concerted action drives expression almost to the correct rostral boundary and, furthermore, multimerization of an individual element can mimic the combined cooperativity of several single elements.
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Charité J, De Graaff W, Vogels R, Meijlink F, Deschamps J. Regulation of the Hox-8 gene: synergism between multimerized cis-acting elements increases responsiveness to positional information. of special interest Dev Biol. 171:1995;294-305 A very detailed and well presented study on the elements which direct Hoxb-8 expression. Here, the authors exactingly dissect primarily the 5' flanking region of Hoxb-8 and reveal that several cis-acting elements interact cooperatively to set the normal Hoxb-8 expression domain. Each of the cis-acting elements can function alone but their concerted action drives expression almost to the correct rostral boundary and, furthermore, multimerization of an individual element can mimic the combined cooperativity of several single elements.
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51
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of special interest. A very extensive and impressive analysis of the regulatory regions of the Hoxc-8 gene which narrows the cis-elements down to very small sequences ideal for biochemical analysis and which speculates on potential factor interactions.
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52
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A long-range regulatory element of Hoxc8 identified by using the pClasper vector
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of special interest. This paper presents a very novel approach, using homologous recombination in yeast to insert the lacZ gene into the Hoxc-8 locus contained within a large genomic fragment, which will likely be of general utility for analysing large genomic regions for regulatory elements.
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Bradshaw MS, Shashikant CS, Belting HG, Bollekens JA, Ruddle FH. A long-range regulatory element of Hoxc8 identified by using the pClasper vector. of special interest Proc Natl Acad Sci USA. 93:1996;2426-2430 This paper presents a very novel approach, using homologous recombination in yeast to insert the lacZ gene into the Hoxc-8 locus contained within a large genomic fragment, which will likely be of general utility for analysing large genomic regions for regulatory elements.
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Yu BD, Hess JL, Horning SE, Brown GAJ, Korsmeyer SJ. Altered Hox expression and segmental identity in Mll-mutant mice. of special interest Nature. 378:1995;505-508 An impressive genetic analysis of the role of Mll (for mixed lineage leukemia), a murine gene with homology to Drosophila trithorax and Polycomb group genes demonstrating its function in the proper expression of murine Hox genes and underlining the evolutionary conservation of this Hox regulatory pathway.
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Nature
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Yu, B.D.1
Hess, J.L.2
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63
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Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other
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64
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Alkema MJ, Van der Lugt NM, Bobeldijk RC, Berns A, Van Lohuizen M. Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. of outstanding interest Nature. 374:1995;724-727 This is a very interesting gain-of-function analysis of bmi-1 which complements this group's earlier loss-of-function approach and demonstrates that this murine gene (with homology to Drosophila polycomb group genes) is regulating Hox gene expression via a repressive mechanism.
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Alkema, M.J.1
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