메뉴 건너뛰기




Volumn 17, Issue 4, 2012, Pages 368-375

Modulating T-cell costimulation as new immunosuppressive concept in organ transplantation

Author keywords

belatacept; costimulation blockade; immunosuppression; organ transplantation

Indexed keywords

ABATACEPT; ABI 793; ALEFACEPT; ASKP 1240; BASILIXIMAB; BELATACEPT; CD28 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; CYCLOSPORIN; EFALIZUMAB; INDOLEAMINE 2,3 DIOXYGENASE; IPILIMUMAB; MONOCLONAL ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PROTEIN BCL XL; RUPLIZUMAB; SIPLIZUMAB; STEROID; TGN 1412; TICILIMUMAB; TORALIZUMAB; UNCLASSIFIED DRUG;

EID: 84864713203     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e328355fc94     Document Type: Review
Times cited : (14)

References (76)
  • 1
    • 80054746860 scopus 로고    scopus 로고
    • Calcineurin inhibitors in kidney transplantation: Friend or foe?
    • Casey MJ, Meier-Kriesche HU. Calcineurin inhibitors in kidney transplantation: friend or foe? Curr Opin Nephrol Hypertens 2011; 20:610-615.
    • (2011) Curr Opin Nephrol Hypertens , vol.20 , pp. 610-615
    • Casey, M.J.1    Meier-Kriesche, H.U.2
  • 2
    • 79951972080 scopus 로고    scopus 로고
    • Long-term renal allograft survival in the united states: A critical reappraisal
    • Lamb KE, Lodhi S, Meier-Kriesche HU. Long-term renal allograft survival in the united states: A critical reappraisal. Am J Transplant 2010; 11:450-462.
    • (2010) Am J Transplant , vol.11 , pp. 450-462
    • Lamb, K.E.1    Lodhi, S.2    Meier-Kriesche, H.U.3
  • 4
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins MK, Schwartz RH. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 1987; 165:302-319.
    • (1987) J Exp Med , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 5
    • 80054851680 scopus 로고    scopus 로고
    • Costimulatory pathways in transplantation
    • Pilat N, Sayegh MH, Wekerle T. Costimulatory pathways in transplantation. Sem Immunol 2011; 23:293-303.
    • (2011) Sem Immunol , vol.23 , pp. 293-303
    • Pilat, N.1    Sayegh, M.H.2    Wekerle, T.3
  • 6
    • 20044386299 scopus 로고    scopus 로고
    • Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties
    • Larsen CP, Pearson TC, Adams AB, et al. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant 2005; 5:443-453.
    • (2005) Am J Transplant , vol.5 , pp. 443-453
    • Larsen, C.P.1    Pearson, T.C.2    Adams, A.B.3
  • 7
    • 23944502334 scopus 로고    scopus 로고
    • Costimulation blockade with belatacept in renal transplantation
    • Vincenti F, Larsen C, Durrbach A, et al. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 2005; 353:770-781.
    • (2005) N Engl J Med , vol.353 , pp. 770-781
    • Vincenti, F.1    Larsen, C.2    Durrbach, A.3
  • 8
    • 77956528156 scopus 로고    scopus 로고
    • Five-year safety and efficacy of belatacept in renal transplantation
    • Vincenti F, Blancho G, Durrbach A, et al. Five-year safety and efficacy of belatacept in renal transplantation. J Am Soc Nephrol 2010; 21:1587-1596.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1587-1596
    • Vincenti, F.1    Blancho, G.2    Durrbach, A.3
  • 9
    • 76949101581 scopus 로고    scopus 로고
    • A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study)
    • Vincenti F, Charpentier B, Vanrenterghem Y, et al. A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study). Am J Transplant 2010; 10:535-546.
    • (2010) Am J Transplant , vol.10 , pp. 535-546
    • Vincenti, F.1    Charpentier, B.2    Vanrenterghem, Y.3
  • 10
    • 76949090842 scopus 로고    scopus 로고
    • A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)
    • Durrbach A, Pestana JM, Pearson T, et al. A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study). Am J Transplant 2010; 10:547-557.
    • (2010) Am J Transplant , vol.10 , pp. 547-557
    • Durrbach, A.1    Pestana, J.M.2    Pearson, T.3
  • 11
    • 84855999161 scopus 로고    scopus 로고
    • Belatacept: From rational design to clinical application
    • Wekerle T, Grinyo JM. Belatacept: from rational design to clinical application. Transpl Int 2012; 25:139-150.
    • (2012) Transpl Int , vol.25 , pp. 139-150
    • Wekerle, T.1    Grinyo, J.M.2
  • 12
    • 84860187339 scopus 로고    scopus 로고
    • Belatacept and Tregs: Friends or foes?
    • Pilat N, Wekerle T. Belatacept and Tregs: friends or foes? Immunotherapy 2012; 4:351-354.
    • (2012) Immunotherapy , vol.4 , pp. 351-354
    • Pilat, N.1    Wekerle, T.2
  • 13
    • 78649990016 scopus 로고    scopus 로고
    • A more selective costimulatory blockade of the CD28-B7 pathway
    • Poirier N, Blancho G, Vanhove B. A more selective costimulatory blockade of the CD28-B7 pathway. Transpl Int 2011; 24:2-11.
    • (2011) Transpl Int , vol.24 , pp. 2-11
    • Poirier, N.1    Blancho, G.2    Vanhove, B.3
  • 14
    • 77952961806 scopus 로고    scopus 로고
    • Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation
    • Poirier N, Azimzadeh AM, Zhang T, et al. Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation. Sci Transl Med 2010; 2:17ra0.
    • (2010) Sci Transl Med , vol.2
    • Poirier, N.1    Azimzadeh, A.M.2    Zhang, T.3
  • 15
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, ODay SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010; 363:711-723.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    Oday, S.J.2    McDermott, D.F.3
  • 16
    • 0036301503 scopus 로고    scopus 로고
    • CTLA-4: New insights into its biological function and use in tumor immunotherapy
    • Egen JG, Kuhns MS, Allison JP. CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat Immunol 2002; 3:611-618.
    • (2002) Nat Immunol , vol.3 , pp. 611-618
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 17
    • 2942711587 scopus 로고    scopus 로고
    • Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients
    • Sidiropoulos PI, Boumpas DT. Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients. Lupus 2004; 13:391-397.
    • (2004) Lupus , vol.13 , pp. 391-397
    • Sidiropoulos, P.I.1    Boumpas, D.T.2
  • 18
    • 0033965079 scopus 로고    scopus 로고
    • Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand
    • Kawai T, Andrews D, Colvin RB, et al. Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat Med 2000; 6:114.
    • (2000) Nat Med , vol.6 , pp. 114
    • Kawai, T.1    Andrews, D.2    Colvin, R.B.3
  • 19
    • 37349029002 scopus 로고    scopus 로고
    • A novel fully human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys
    • Imai A, Suzuki T, Sugitani A, et al. A novel fully human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys. Transplantation 2007; 84:1020-1028.
    • (2007) Transplantation , vol.84 , pp. 1020-1028
    • Imai, A.1    Suzuki, T.2    Sugitani, A.3
  • 20
    • 67650966708 scopus 로고    scopus 로고
    • A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: Induction and maintenance therapy
    • Aoyagi T, Yamashita K, Suzuki T, et al. A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: induction and maintenance therapy. Am J Transplant 2009; 9:1732-1741.
    • (2009) Am J Transplant , vol.9 , pp. 1732-1741
    • Aoyagi, T.1    Yamashita, K.2    Suzuki, T.3
  • 21
    • 84863190818 scopus 로고    scopus 로고
    • Long-term hepatic allograft acceptance based on cd40 blockade by askp1240 in nonhuman primates
    • Epub ahead of print
    • Oura T, Yamashita K, Suzuki T, et al. Long-Term Hepatic Allograft Acceptance Based on CD40 Blockade by ASKP1240 in Nonhuman Primates. Am J Transplant 2012 [Epub ahead of print].
    • (2012) Am J Transplant
    • Oura, T.1    Yamashita, K.2    Suzuki, T.3
  • 22
    • 0035954670 scopus 로고    scopus 로고
    • Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes
    • Ellis CN, Krueger GG. Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med 2001; 345:248-255.
    • (2001) N Engl J Med , vol.345 , pp. 248-255
    • Ellis, C.N.1    Krueger, G.G.2
  • 23
    • 67650506103 scopus 로고    scopus 로고
    • Alefacept promotes costimulation blockade based allograft survival in nonhuman primates
    • Weaver TA, Charafeddine AH, Agarwal A, et al. Alefacept promotes costimulation blockade based allograft survival in nonhuman primates. Nat Med 2009; 15:746-749.
    • (2009) Nat Med , vol.15 , pp. 746-749
    • Weaver, T.A.1    Charafeddine, A.H.2    Agarwal, A.3
  • 24
    • 84862568529 scopus 로고    scopus 로고
    • Efficacy and Safety of alefacept in combination with tacrolimus, mycophenolate mofetil and steroids in de novo kidney transplantation [Abstract]
    • Rostaing L, Mourad M, Charpentier B, et al. Efficacy and Safety of alefacept in combination with tacrolimus, mycophenolate mofetil and steroids in de novo kidney transplantation [Abstract]. Am J Transplant 2011; 11 (Suppl s2):98.
    • (2011) Am J Transplant , vol.11 , Issue.SUPPL. S2 , pp. 98
    • Rostaing, L.1    Mourad, M.2    Charpentier, B.3
  • 25
    • 80054751201 scopus 로고    scopus 로고
    • A Phase 2 Study to Assess the Safety and Efficacy of Alefacept (ALEF) in de Novo Kidney Transplant Recipients [Abstract]
    • Bromberg JS, Cibrik D, Steinberg S, et al. A Phase 2 Study to Assess the Safety and Efficacy of Alefacept (ALEF) in De Novo Kidney Transplant Recipients [Abstract]. Am J Transplant 2011; 11 (Suppl s2):190.
    • (2011) Am J Transplant , vol.11 , Issue.SUPPL. S2 , pp. 190
    • Bromberg, J.S.1    Cibrik, D.2    Steinberg, S.3
  • 26
    • 34250202520 scopus 로고    scopus 로고
    • A phase I/II randomized open-label multicenter trial of efalizumab, a humanized anti-CD11a, anti-LFA-1 in renal transplantation
    • Vincenti F, Mendez R, Pescovitz M, et al. A phase I/II randomized open-label multicenter trial of efalizumab, a humanized anti-CD11a, anti-LFA-1 in renal transplantation. Am J Transplant 2007; 7:1770-1777.
    • (2007) Am J Transplant , vol.7 , pp. 1770-1777
    • Vincenti, F.1    Mendez, R.2    Pescovitz, M.3
  • 27
    • 79954571318 scopus 로고    scopus 로고
    • Cell surface signaling molecules in the control of immune responses: A tide model
    • Zhu Y, Yao S, Chen L. Cell surface signaling molecules in the control of immune responses: a tide model. Immunity 2011; 34:466-478.
    • (2011) Immunity , vol.34 , pp. 466-478
    • Zhu, Y.1    Yao, S.2    Chen, L.3
  • 31
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    • Salomon B, Bluestone JA. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol 2001; 19:225-252.
    • (2001) Annu Rev Immunol , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.A.2
  • 33
    • 0030694234 scopus 로고    scopus 로고
    • The emerging role of CTLA-4 as an immune attenuator
    • Thompson CB, Allison JP. The emerging role of CTLA-4 as an immune attenuator. Immunity 1997; 7:445-450.
    • (1997) Immunity , vol.7 , pp. 445-450
    • Thompson, C.B.1    Allison, J.P.2
  • 34
    • 0029163387 scopus 로고
    • CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL
    • Boise LH, Minn AJ, Noel PJ, et al. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity 1995; 3:87-98.
    • (1995) Immunity , vol.3 , pp. 87-98
    • Boise, L.H.1    Minn, A.J.2    Noel, P.J.3
  • 35
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • Linsley PS, Greene JL, Brady W, et al. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994; 1:793-801.
    • (1994) Immunity , vol.1 , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3
  • 36
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi OS, Zheng Y, Nakamura K, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 2011; 332:600-603.
    • (2011) Science , vol.332 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3
  • 37
    • 0037100256 scopus 로고    scopus 로고
    • Cutting edge: Targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells
    • Hwang KW, Sweatt WB, Brown IE, et al. Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells. J Immunol 2002; 169:633-637.
    • (2002) J Immunol , vol.169 , pp. 633-637
    • Hwang, K.W.1    Sweatt, W.B.2    Brown, I.E.3
  • 38
    • 79954577066 scopus 로고    scopus 로고
    • B7-H2 is a costimulatory ligand for CD28 in human
    • Yao S, Zhu Y, Zhu G, et al. B7-H2 is a costimulatory ligand for CD28 in human. Immunity 2011; 34:729-740.
    • (2011) Immunity , vol.34 , pp. 729-740
    • Yao, S.1    Zhu, Y.2    Zhu, G.3
  • 39
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte MJ, Keir ME, Phamduy TB, et al. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007; 27:111-122.
    • (2007) Immunity , vol.27 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3
  • 40
    • 0025830902 scopus 로고
    • CTLA-4 is a second receptor for the B cell activation antigen B7
    • Linsley PS, Brady W, Urnes M, et al. CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 1991; 174:561-569.
    • (1991) J Exp Med , vol.174 , pp. 561-569
    • Linsley, P.S.1    Brady, W.2    Urnes, M.3
  • 41
    • 0027451441 scopus 로고
    • Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion
    • Lin H, Bolling SF, Linsley PS, et al. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J Exp Med 1993; 178:1801-1806.
    • (1993) J Exp Med , vol.178 , pp. 1801-1806
    • Lin, H.1    Bolling, S.F.2    Linsley, P.S.3
  • 42
    • 0028135078 scopus 로고
    • CTLA4Ig prolongs allograft survival while suppressing cell-mediated immunity
    • Baliga P, Chavin KD, Qin L, et al. CTLA4Ig prolongs allograft survival while suppressing cell-mediated immunity. Transplantation 1994; 58:1082-1090.
    • (1994) Transplantation , vol.58 , pp. 1082-1090
    • Baliga, P.1    Chavin, K.D.2    Qin, L.3
  • 43
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381:434-438.
    • (1996) Nature , vol.381 , pp. 434-438
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 44
    • 0036773925 scopus 로고    scopus 로고
    • Mechanisms of transplant tolerance induction using costimulatory blockade
    • Wekerle T, Kurtz J, Bigenzahn S, et al. Mechanisms of transplant tolerance induction using costimulatory blockade. Curr Opin Immunol 2002; 14:592-600.
    • (2002) Curr Opin Immunol , vol.14 , pp. 592-600
    • Wekerle, T.1    Kurtz, J.2    Bigenzahn, S.3
  • 45
    • 65349185047 scopus 로고    scopus 로고
    • The clinical utility of inhibiting CD28-mediated costimulation
    • Linsley PS, Nadler SG. The clinical utility of inhibiting CD28-mediated costimulation. Immunol Rev 2009; 229:307-321.
    • (2009) Immunol Rev , vol.229 , pp. 307-321
    • Linsley, P.S.1    Nadler, S.G.2
  • 46
    • 84858444074 scopus 로고    scopus 로고
    • Decreased frequency of peripheral CD4-CD161-Th17-precursor cells in kidney transplant recipients on longterm therapy with Belatacept
    • Vondran FW, Timrott K, Kollrich S, et al. Decreased frequency of peripheral CD4-CD161-Th17-precursor cells in kidney transplant recipients on longterm therapy with Belatacept. Transpl Int 2012; 25:455-463.
    • (2012) Transpl Int , vol.25 , pp. 455-463
    • Vondran, F.W.1    Timrott, K.2    Kollrich, S.3
  • 47
    • 63749109588 scopus 로고    scopus 로고
    • CD28 co-stimulation down regulates Th17 development
    • Bouguermouh S, Fortin G, Baba N, et al. CD28 co-stimulation down regulates Th17 development. PloS One 2009; 4:e5087.
    • (2009) PloS One , vol.4
    • Bouguermouh, S.1    Fortin, G.2    Baba, N.3
  • 48
    • 84856023167 scopus 로고    scopus 로고
    • Belatacept does not activate indoleamine 2,3-dioxygenase (IDO) in de novo liver transplant recipients
    • abstract
    • Bigenzahn S, Pratschke J, Koenigsrainer A, et al. Belatacept does not activate indoleamine 2,3-dioxygenase (IDO) in de novo liver transplant recipients. Am J Transplant 2011; s2:263-264. (abstract).
    • (2011) Am J Transplant , Issue.S2 , pp. 263-264
    • Bigenzahn, S.1    Pratschke, J.2    Koenigsrainer, A.3
  • 49
    • 0031034123 scopus 로고    scopus 로고
    • CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28
    • Tacke M, Hanke G, Hanke T, Hunig T. CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28. Eur J Immunol 1997; 27:239-247.
    • (1997) Eur J Immunol , vol.27 , pp. 239-247
    • Tacke, M.1    Hanke, G.2    Hanke, T.3    Hunig, T.4
  • 50
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    • Suntharalingam G, Perry MR, Ward S, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006; 355:1018-1028.
    • (2006) N Engl J Med , vol.355 , pp. 1018-1028
    • Suntharalingam, G.1    Perry, M.R.2    Ward, S.3
  • 51
    • 53149092106 scopus 로고    scopus 로고
    • CD28 costimulation is essential for human T regulatory expansion and function
    • Golovina TN, Mikheeva T, Suhoski MM, et al. CD28 costimulation is essential for human T regulatory expansion and function. J Immunol 2008; 181:2855-2868.
    • (2008) J Immunol , vol.181 , pp. 2855-2868
    • Golovina, T.N.1    Mikheeva, T.2    Suhoski, M.M.3
  • 52
    • 65349188127 scopus 로고    scopus 로고
    • Translating costimulation blockade to the clinic: Lessons learned from three pathways
    • Ford ML, Larsen CP. Translating costimulation blockade to the clinic: lessons learned from three pathways. Immunol Rev 2009; 229:294-306.
    • (2009) Immunol Rev , vol.229 , pp. 294-306
    • Ford, M.L.1    Larsen, C.P.2
  • 53
    • 0036130828 scopus 로고    scopus 로고
    • CD40L stabilizes arterial thrombi by a beta3 integrin: Dependent mechanism
    • Andre P, Prasad KS, Denis CV, et al. CD40L stabilizes arterial thrombi by a beta3 integrin: dependent mechanism. Nat Med 2002; 8:247-252.
    • (2002) Nat Med , vol.8 , pp. 247-252
    • Andre, P.1    Prasad, K.S.2    Denis, C.V.3
  • 54
    • 0032996025 scopus 로고    scopus 로고
    • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
    • Kirk A, Burkly L, Batty D, et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999; 5:686-693.
    • (1999) Nat Med , vol.5 , pp. 686-693
    • Kirk, A.1    Burkly, L.2    Batty, D.3
  • 55
    • 0033056692 scopus 로고    scopus 로고
    • Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154
    • Kenyon NS, Fernandez LA, Lehmann R, et al. Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154. Diabetes 1999; 48:1473-1481.
    • (1999) Diabetes , vol.48 , pp. 1473-1481
    • Kenyon, N.S.1    Fernandez, L.A.2    Lehmann, R.3
  • 56
    • 77953694980 scopus 로고    scopus 로고
    • Therapeutic interventions targeting CD40L (CD154) and CD40: The opportunities and challenges
    • Law C, Grewal I. Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges. Adv Exp Med Biol 2009; 647:8-36.
    • (2009) Adv Exp Med Biol , vol.647 , pp. 8-36
    • Law, C.1    Grewal, I.2
  • 57
    • 0037443913 scopus 로고    scopus 로고
    • Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates
    • Haanstra KG, Ringers J, Sick EA, et al. Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates. Transplantation 2003; 75:637-643.
    • (2003) Transplantation , vol.75 , pp. 637-643
    • Haanstra, K.G.1    Ringers, J.2    Sick, E.A.3
  • 58
    • 0037108717 scopus 로고    scopus 로고
    • Anti-CD40 therapy extends renal allograft survival in rhesus macaques
    • Pearson TC, Trambley J, Odom K, et al. Anti-CD40 therapy extends renal allograft survival in rhesus macaques. Transplantation 2002; 74:933-940.
    • (2002) Transplantation , vol.74 , pp. 933-940
    • Pearson, T.C.1    Trambley, J.2    Odom, K.3
  • 59
    • 19944412462 scopus 로고    scopus 로고
    • Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival
    • Adams AB, Shirasugi N, Jones TR, et al. Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol 2005; 174:542-550.
    • (2005) J Immunol , vol.174 , pp. 542-550
    • Adams, A.B.1    Shirasugi, N.2    Jones, T.R.3
  • 60
    • 12644262358 scopus 로고    scopus 로고
    • CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
    • Kirk AD, Harlan DM, Armstrong NN, et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci U S A 1997; 94:8789-8794.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 8789-8794
    • Kirk, A.D.1    Harlan, D.M.2    Armstrong, N.N.3
  • 61
    • 68149165399 scopus 로고    scopus 로고
    • Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation
    • Gilson CR, Milas Z, Gangappa S, et al. Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation. J Immunol 2009; 183:1625-1635.
    • (2009) J Immunol , vol.183 , pp. 1625-1635
    • Gilson, C.R.1    Milas, Z.2    Gangappa, S.3
  • 62
    • 77957576120 scopus 로고    scopus 로고
    • Transplantation tolerance through mixed chimerism
    • Pilat N, Wekerle T. Transplantation tolerance through mixed chimerism. Nat Rev 2010; 6:594-605.
    • (2010) Nat Rev , vol.6 , pp. 594-605
    • Pilat, N.1    Wekerle, T.2
  • 64
    • 78650899002 scopus 로고    scopus 로고
    • Selective targeting of human alloresponsive CD8-effector memory T cells based on CD2 expression
    • Lo DJ, Weaver TA, Stempora L, et al. Selective targeting of human alloresponsive CD8-effector memory T cells based on CD2 expression. Am J Transplant 2011; 11:22-33.
    • (2011) Am J Transplant , vol.11 , pp. 22-33
    • Lo, D.J.1    Weaver, T.A.2    Stempora, L.3
  • 65
    • 0028351526 scopus 로고
    • Mechanism of lymphocyte functionassociated molecule 3-Ig fusion proteins inhibition of T cell responses. Structure/function analysis in vitro and in human CD2 transgenic mice
    • Majeau GR, Meier W, Jimmo B, et al. Mechanism of lymphocyte functionassociated molecule 3-Ig fusion proteins inhibition of T cell responses. Structure/function analysis in vitro and in human CD2 transgenic mice. J Immunol 1994; 152:2753-2767.
    • (1994) J Immunol , vol.152 , pp. 2753-2767
    • Majeau, G.R.1    Meier, W.2    Jimmo, B.3
  • 66
  • 67
    • 38549088096 scopus 로고    scopus 로고
    • HLA-mismatched renal transplantation without maintenance immunosuppression
    • Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358:353-361.
    • (2008) N Engl J Med , vol.358 , pp. 353-361
    • Kawai, T.1    Cosimi, A.B.2    Spitzer, T.R.3
  • 68
    • 33644872811 scopus 로고    scopus 로고
    • LFA-1 (CD11a) as a therapeutic target
    • Nicolls MR, Gill RG. LFA-1 (CD11a) as a therapeutic target. Am J Transplant 2006; 6:27-36.
    • (2006) Am J Transplant , vol.6 , pp. 27-36
    • Nicolls, M.R.1    Gill, R.G.2
  • 69
    • 0025782478 scopus 로고
    • A role for adhesion molecules in contact-dependent T help for B cells
    • Owens T. A role for adhesion molecules in contact-dependent T help for B cells. Eur J Immunol 1991; 21:979-983.
    • (1991) Eur J Immunol , vol.21 , pp. 979-983
    • Owens, T.1
  • 70
    • 0023934515 scopus 로고
    • Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production
    • Sanders ME, Makgoba MW, Sharrow SO, et al. Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. J Immunol 1988; 140:1401-1407.
    • (1988) J Immunol , vol.140 , pp. 1401-1407
    • Sanders, M.E.1    Makgoba, M.W.2    Sharrow, S.O.3
  • 71
    • 84861093557 scopus 로고    scopus 로고
    • Combined costimulatory and leukocyte functional antigen-1 blockade prevents transplant rejection mediated by heterologous immune memory alloresponses
    • Kitchens WH, Haridas D, Wagener ME, et al. Combined Costimulatory and Leukocyte Functional Antigen-1 Blockade Prevents Transplant Rejection Mediated by Heterologous Immune Memory Alloresponses. Transplantation 2012; 93:997-1005.
    • (2012) Transplantation , vol.93 , pp. 997-1005
    • Kitchens, W.H.1    Haridas, D.2    Wagener, M.E.3
  • 72
    • 84855943600 scopus 로고    scopus 로고
    • Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8-memory T cells
    • Kitchens WH, Haridas D, Wagener ME, et al. Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8-memory T cells. Am J Transplant 2012; 12:69-80.
    • (2012) Am J Transplant , vol.12 , pp. 69-80
    • Kitchens, W.H.1    Haridas, D.2    Wagener, M.E.3
  • 73
    • 78649835002 scopus 로고    scopus 로고
    • LFA-1-specific therapy prolongs allograft survival in rhesus macaques
    • Badell IR, Russell MC, Thompson PW, et al. LFA-1-specific therapy prolongs allograft survival in rhesus macaques. J Clin Invest 2010; 120:4520-4531.
    • (2010) J Clin Invest , vol.120 , pp. 4520-4531
    • Badell, I.R.1    Russell, M.C.2    Thompson, P.W.3
  • 74
    • 77956145092 scopus 로고    scopus 로고
    • Experience with a novel efalizumabbased immunosuppressive regimen to facilitate single donor islet cell transplantation
    • Turgeon NA, Avila JG, Cano JA, et al. Experience with a novel efalizumabbased immunosuppressive regimen to facilitate single donor islet cell transplantation. Am J Transplant 2010; 10:2082-2091.
    • (2010) Am J Transplant , vol.10 , pp. 2082-2091
    • Turgeon, N.A.1    Avila, J.G.2    Cano, J.A.3
  • 75
    • 82155178641 scopus 로고    scopus 로고
    • LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function
    • Reisman NM, Floyd TL, Wagener ME, et al. LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function. Blood 2011; 118:5851-5861.
    • (2011) Blood , vol.118 , pp. 5851-5861
    • Reisman, N.M.1    Floyd, T.L.2    Wagener, M.E.3
  • 76
    • 79953800720 scopus 로고    scopus 로고
    • Costimulatory blockade with mTor inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation
    • Bestard O, Cassis L, Cruzado JM, et al. Costimulatory blockade with mTor inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation. Transpl Int 2011; 24:451-460.
    • (2011) Transpl Int , vol.24 , pp. 451-460
    • Bestard, O.1    Cassis, L.2    Cruzado, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.